Search results
You searched for "".
-
Screening for auditory impairment in resource-poor countries
J Postgrad Med 2004;50:178-179Rai S, Puliyel JMLoss of hearing, very early in life, can affect the development of speech and language, social and emotional development, and influence behaviour and academic achievement.[1] The critical or sensitive period for the acquisition of language extends from 1 to 5 years of age. However, impairment of hearing commencing after 5 years of age can also have serious consequences. Ninety-five per cent of school children suffer from middle-ear disease, sometime in the first 10 years of their life.[2] Otorrh Read More... -
Determining the point of indifference - where costs of selective and universal immunization against hepatitis B are identical, in a cost-minimization exercise
Indian Journal of Gastroenterology , Year 2004, Volume 23, Issue 4 154-156Varghese R Mathew, Abraham Jacob, James Jyotsna, Puliyel Jacob M -
Magnitude of the problem of retinopathy of prematurity. experience in a large maternity unit with a medium size level-3 nursery.
Indian J Ophthalmol. 2001 Sep;49(3):187-8.Varughese S, Jain S, Gupta N, Singh S, Tyagi V, Puliyel JM.Neonates Delhi St Stephens Hospital. This report describes the extent and severity of retinopathy of prematurity (ROP) in a large maternity unit. The screening of 79 preterm babies showed that ophthalmic examinations should become an important part of neonatal care. -
Truth and evidence based medicine: spin is everything.
BMJ. 2004 Oct 30;329(7473):1043Tiwari L, Puliyel JM, Upadhyay P.Surfactant, Cochrane meta-analysis -
Evidence-Based Investigation into the Relation Between Sexual Intercourse and Pregnancy
Rapid response in ebmj to BMJ 2004; 329: 1051Jacob M. Puliyel, Noopur Baijal, Dherain Narula. -
Should immunisation against hepatitis B take priority over provision of clean drinking water?
BMJ 1999;319:188Puliyel J -
Adverse local reactions from accidental BCG overdose in infants.
BMJ. 1996 Aug 31;313(7056):528-9.Puliyel JM, Hughes A, Chiswick ML, Mughal MZ. -
Not by bread alone project: a 2-year follow-up report
Child: Care, Health and Development Volume 31 Page 703 - 6. November 2005V. Taneja, R. Aggarwal, R. S. Beri and J. M. PuliyelBACKGROUND: We have previously reported the developmental gains achieved, after introducing a simple programme of structured play to stimulate children in an orphanage. It was envisaged that the caregivers could continue the programme. However, the enthusiasm of the caregivers waned over the year the programme was entrusted to them. After 1 year, a full time play therapist was recruited to rejuvenate the play programme. METHODS: Children's development was assessed using the Indian adaptatio Read More... -
The incidence and nature of drug abuse in adolescence personality correlates and predictive models.
Indian Pediatr. 1981 Jul;18(7):443-8.: Puliyel JM, Agrawal RK, Chansoria M. -
Global health and the Bill and Melinda Gates Foundation
Lancet 2009;373:2195-6Dabade G, Puliyel J. -
Policy analysis of the use of Hepatitis B, Hemophilius influenzae type B, Steptococcus pneuomniae-conjugate and Rotavirus vaccines in the national immunization schedules.
Health Econ. 2004 Nov;13(11):1147; author reply 1147-8.Puliyel JM.Mark Miller, Call for retraction of paper, Exaggeration of deaths caused by Hepatitis B in India -
Selling scare
The TelegraphG.S.MudurMiller Call for retraction in Health Economics -
Citing the evidence for IAP vaccine recommendations
Pediascene Mar-June 2004Puliyel JM.‘IAP Policies, Guidelines and Recommendations on Immunization 2003’ Citing the Evidence -
Vitamin d level in slum children of Delhi
Indian Pediatr. 2004 Oct;41(10):1076-7.Tiwari L, Puliyel JM.Sundernagri -
Full correspondence with Health Economics calling for retraction of Millers Paper on estimate of Deaths of Hepatitis B in India
Puliyel JM, Miller M, Alan MaynardMark Miller, CDC Atlanta, WHO -
Gradenigo's syndrome.
Indian Pediatr. 2006 May;43(5):456-7Rangasami JJ, Puliyel J.West Middleswx University Hospital London -
Signs of inflammation in children that can kill (SICK score): Preliminary prospective validation of a new non-invasive measure of severity-of-illness.
J Postgrad Med. 2006 Apr-Jun;52(2):102-5.Bhal S, Tygai V, Kumar N, Sreenivas V, Puliyel JMTriage score Sick score calculator. BACKGROUND: Signs of Inflammation in Children that can Kill (SICK score) is a new severity-of-illness score. It uses the physical signs of the Systemic Inflammatory Response Syndrome (SIRS) and its continuum - the Multiple Organ Dysfunction Syndrome (MODS). The development of the score used multiple logistic regression model coefficients converted to integer scores that have been published earlier. AIMS: The present study was done to validate the scoring syst Read More... -
Prone versus supine position in mechanically ventilated children: a pilot study
Med Sci Monit. 2005 May;11(5):CR235-240. Epub 2005 Apr 28.Sawhney A, Kumar N, Sreenivas V, Gupta S, Tyagi V, Puliyel JM. -
Severe anaemia owing to hookworm in a 12-day-old Nepalese infant.
Ann Trop Paediatr. 2004 Dec;24(4):361-3.Tiwari L, James J, Chowdhary S, Sharma A, Puliyel JM. -
Polio vaccine and Gresham's law
Indian J Pediatr. 2004 Dec;71(12):1141;Sathyamala C, Puliyel JM.If the polio eradication program fails, oral polio vaccine will be withdrawn from the market. User fee will be introduced for the injectable polio vaccine. The poor will be unprotected and then we will have a catastrophic epidemic. -
Rotavirus vaccines
Lancet. 2004 Jul 17-23;364(9430):245-6.Narula D, Tiwari L, Puliyel JM. -
Not By Bread Alone : Proposal for funding from BBC Blue Peter
Jacob Puliyel -
Building for the future: influence of housing on intelligence quotients of children in an urban slum.
Health Policy Plan. 2002 Dec;17(4):420-4.Choudhary R, Sharma A, Agarwal KS, Kumar A, Sreenivas V, Puliyel JM.NTRODUCTION: Interventions on behalf of the marginalized in society can assume many formats. In an urban slum the Government of Delhi built one-room houses for some of the residents in what is termed a 'plot area'. Not all residents could be accommodated in the project and the remainder continued to live next door in shanty houses of the slum. Nineteen years later, young children who had migrated with their parents, have grown up and have children of their own. We looked at the develop Read More... -
Ketoacid levels may alter osmotonicity in diabetic ketoacidosis and precipitate cerebral edema.
Arch Dis Child. 2003 Apr;88(4):366.Puliyel JM, Bhambhani V. -
Computerised-hepatitis B-model is subject to processing axiom: garbage in, garbage out.
J Hepatol. 2003 Jul;39(1):133; author reply 134-5.Tiwari L, Varghese RM, Puliyel JM. -
Selective decontamination of digestive tract in intensive care.
Lancet. 2003 Dec 20;362(9401):2119; author reply 2119-20.Sahni M, Varghese RM, Puliyel JM. -
Plea to restore public funding for vaccine development.
Lancet. 2004 Feb 21;363(9409):659.Puliyel JM. -
Long QT syndrome manifesting as pulseless epilepsy.
Indian J Pediatr. 2003 Jan;70(1):97-100.Abass FA, Shahi M, Kumar N, Bhargava M, Gupta S, Puliyel JM.A-10-year-old child admitted with repeated seizures due to the long QT syndrome is described. The cardiac origin of the epilepsy was suggested by the fact that during the episode of convulsions his peripheral pulses were not palpable. -
Routine hepatitis B immunization in India: cost effectiveness needs reassessment.
Indian J Pediatr. 2003 Feb;70(2):188.Puliyel JM, Mittal R, Tyagi V, Gupta S.Kane M, Miller MA. -
Play in orphanages.
Indian J Pediatr. 2004 Apr;71(4):297-9.Taneja V, Beri RS, Puliyel JM.OBJECTIVES: This paper attempts to validate the programme of structured play lasting 90 minutes a day, for use in orphanages, to check if it can be replicated in other orphanages, with similar results. METHODS: A 2-week workshop on the structured play scheme was conducted at the Missionaries of Charity Orphanage in Delhi, the venue of the original project. 15 MOC sisters from 6 centers attended the workshop. The authors selected the MOC orphanage at Chandigarh to track the benefits of the progra Read More... -
Ask the Doc: The Hindu
2/4/06 Sunday Magazine The HinduPuliyel JTourette Syndrome, Asthma, Constipation -
Death of twins after intravenous varicella zoster immunoglobulin.
Ann Pharmacother. 2005 Jan;39(1):198-9.Bhambhani V, Kumar N, Puliyel JM. -
The dummies' guide to risk-benefit analysis of vaccines.
Pediatrics. 2002 Jul;110(1 Pt 1):193.Puliyel J -
Triage score for severity of illness.
Indian Pediatr. 2003 Mar;40(3):204-10Kumar N, Thomas N, Singhal D, Puliyel JM, Sreenivas V.Sick score, sick calculator. OBJECTIVE: To evolve a triage scoring system for severity of illness based on clinical variables related to systemic inflammatory response syndrome (SIRS). DESIGN: Prospective study in a tertiary-care hospital. METHODS: Consecutive pediatric patients admitted to the ward or pediatric intensive care unit (PICU) were studied. The respiratory rate, heart rate, capillary refill time, oxygen saturation (SpO2), systolic blood pressure and temperature were noted, Sensorium Read More... -
The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India.
Arch Dis Child. 2002 Aug;87(2):111-3.Agarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM.AIMS: To compare the vitamin D status of 34 children, 9-24 months old, living in an area of Delhi renowned for high levels of atmospheric pollution (Mori Gate), with a comparable age matched group of children from a less polluted (Gurgaon) area of the city. METHODS: Serum concentrations of calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), and 1,25-dihydroxyvitamin D (1,25(OH)2D) were measured. Haze scores, regarded as a surrogate marker of solar UVB r Read More... -
Vaccine promotion is circumventing market forces.
BMJ. 2002 Apr 20;324(7343):975.Ojha RK, Abraham J, Khosla M, Puliyel JM.No abstract Global alliance on vaccines and immunizations. -
Evaluation of Leukocyte Esterase Reagent Strips for Rapid Diagnosis of Pyogenic Meningitis
Indian Pediatrics 1999;36: 955-956Angom Bisharda, Ruchie Chowdhury, Jacob M. Puliyel.The detection of polymorphonuclear leukocytes in the CSF is a fairly reliable indicator of pyogenic meningitis but facilities required for its detection are not always available in rural hospitals in developing countries. To circumvent this problem Moosa et al.(1) tested the ability of urine dipsticks on CSF to help in the early diagnosis of pyogenic meningitis. The urine dipstick leukocyte esterase test uses the ability of esterase enzyme present in the polymorphonuclear leucocytes to conv Read More... -
Brief Report: IMA Subcommittee on Immunization Report on Meeting of Experts 14 May 2006 Hotel Imperial Janpath
http://www.imanational.com/Hepatitis/Report.htmProf SK Mittal Dr Dharam Prakash, Dr Onkar Mittal, Dr C Sathyamala, Dr Jacob Puliyel, Dr T Gera Dr Joseph L MathewThis is a brief report of the meeting of Experts held at Hotel Imperial on 14/5/06. The meeting was sponsored jointly by the IMA and PLAN international (India) Indian Medical Association Subcommittee on Immunization Report on Hepatitis B and Poliomyelitis in India Chairperson Professor S K Mittal Indian Medical Association New Delhi 2006 Contents Section 1 Brief Report Read More... -
Issues Related to Hepatitis B Vaccination in India:
Ashish Batham, Dherian Narula, Tanmay Toteja, V Sreenivas and Jacob M PuliyelMeeting of Experts on Draft White Paper presented by Jacob Puliyel. Systematic Review and Meta analysis -
Full Report on Meeting of Experts to discuss White Papers presented by the IMA Subcommittee on Immunization
http://www.imanational.com/Hepatitis/PositionPaper.htmProf SK Mittal Dr Dharam Prakash, Dr Onkar Mittal, Dr C Sathyamala, Dr Jacob Puliyel, Dr T Gera Dr Joseph L MathewHepatitis B, -
Prone versus supine position in mechanically ventilated babies
J Pediatrics and Child Health. 2006;42: A8Baijal N, Puliyel J, Beri R, Sreenivas V.Royal Australasian College of Physicians. Pediatrics and Child Health Division Annual Conference Queensland 2006 -
Lessons from the polio campaign
http://www.hindu.com/mag/2006/11/19/stories/2006111900100400.htm The Hindu Magazine 19/11/06 Page 4Jacob M PuliyelIT is now being acknowledged that the National Polio Eradication Programme did not work according to plan. The failure of this magic bullet approach (repeated doses of oral polio vaccine) to solve what is essentially a water and sanitation problem was predictable. Yet, that did not mitigate the sadness its failure caused among many of us who have worked tirelessly to make it succeed. The Indian Medical Association (IMA) Sub-Committee on Immunisation debated on whether to go public with its find Read More... -
GAVI funding and assessment of vaccine cost-effectiveness
Lancet 2007;369:189Amit Kumar, Puliyel JM -
Regulating vaccines: Can health-economics tools be used profitably?
Indian Pediatrics 2007;44:11-14Dhanasiri SK, Puliyel JM.Editorial Indian Pediatrics 2007; 44:11-14 Regulating Vaccines: Can Health-Economics Tools be used Profitably? Direct-to-consumer vaccine advertisements are a recent phenomenon. In India a newborn can make up to 27 visits to the doctor for immunizations before his fifth birthday(1) (Table I). The vaccines cost approximately Rs 11,000. There is a built-in incentive for doctors to prescribe the vaccines. After a market presence is established, in the next stage the equity argume Read More... -
Discordant twins with the smaller baby appropriate for gestational age – unusual manifestation of superfoetation: A case report
BMC Pediatrics 2007, 7:2Noopur Baijal* 1 , Mohit Sahni* 1 , Neeraj Verma* 1 , Amit Kumar* 1 , Nittin Parkhe* 2 and Jacob M Puliyel* 1Case report . Discordant twins with the smaller baby appropriate for gestational age – unusual manifestation of superfoetation: A case report Noopur Baijal* 1 , Mohit Sahni* 1 , Neeraj Verma* 1 , Amit Kumar* 1 , Nittin Parkhe* 2 and Jacob M Puliyel* 1 1Department of Pediatrics and Neonatology St Stephens Hospital, Tis Hazari, Delhi 110054, India 2Department of Radiology, St Stephens Hospital, Tis Hazari, Delhi 110054, India BMC Pediatrics 2007, 7:2 doi:10.1186/1471-2431-7-2 Read More... -
A simple strategy to improve first breath oxygen delivery by self inflating bag.
Resuscitation. 2000 Aug 1;45(3):221-4.Agarwal KS, Puliyel JM.The text book of Pediatric Advanced Life Support of the American Heart Association recommends that a reservoir is used with a self inflating bag valve device. The figure in the book suggests that if such a device is connected to an oxygen supply, the oxygen will fill the bag first and then go on to fill the reservoir. However the valve structure of the self-inflating device does not permit active entry of oxygen into the bag, unless the bag is deflated and allowed to reinflate, drawing oxygen fr Read More... -
Using gross national product to calculate acceptable immunisation costs: deploying cost-effectiveness calculations in reverse.
Pharmacoeconomics. 2003;21(7):497-9.Tyagi V, Singh SK, Sawhney A, Taneja V, Puliyel JM. -
Gall bladder wall edema in serology proven pediatric dengue hemorrhagic fever: a useful diagnostic finding which may help in prognostication.
J Trop Pediatr. 2000 Jun;46(3):179-81.Gupta S, Singh SK, Taneja V, Goulatia RK, Bhagat A, Puliyel JM. -
Not by bread alone: Impact of a structured 90-minute play session on the development of children in an orphanage
Child: Care Health & Development 2002; 28:95-100Taneja V, Sriram S, Beri RS, Sreenivas V, Aggarwal R, Kaur S, Puliyel JM. -
The circus dwarf--a new sign for early diagnosis of Down's syndrome.
Indian Pediatr. 1989 Oct;26(10):1062-3.Puliyel J, Nair LT. -
Lesch Nyhan syndrome.
Indian Pediatr. 1984 Mar;21(3):251-2.Puliyel JM, Kumar M. -
Type II Waardenburg syndrome.
Indian Pediatr. 1988 Apr;25(4):384-6.Varughese S, Kumar A, Rao S, Puliyel JM. -
Hypothyroidism with multiple congenital anomalies.
Indian Pediatr. 1983 Nov;20(11):865-7.Puliyel JM, Thomas PG. -
Newer vaccines: like Marie Antoinette said, "let the poor eat cake".
Indian Pediatr. 1998 Dec;35(12):1245-9.Puliyel JM. -
Ocular atropine induced psychosis--is there a direct access route to the brain?
J Assoc Physicians India. 1990 Jun;38(6):444-5.Varghese S, Vettath N, Iyer K, Puliyel JM, Puliyel MM. -
Plasma exchange in a child with systemic lupus erythematosus antiphospholipid antibodies and profound deafness.
Ann Trop Paediatr. 2002 Mar;22(1):109-10.Agarwal K, Thomas N, Taneja V, Beri RS, Khanduri U, Puliyel JM. -
Comparative study of the personality correlates and nature of drug abuse in schools and colleges.
Indian J Pediatr. 1982 Sep-Oct;49(400):671-9.Agrawal RK, Puliyel JM, Chansoria M, Mukerjee B, Kaul KK. -
Cushingoid adrenal hyperplasia in infancy.
Aust Paediatr J. 1986 May;22(2):139-41.Puliyel JM, Komaranchath A, Kumar KR.Cushing's syndrome, a characteristic pattern of obesity with hypertension due to the hyperfunction of the adrenal cortex, is relatively rare in infancy. Thirty-six infants have been reported in world literature, most of whom have had adrenal tumours. There are only eight reported cases of infants under the age of 1 year with adrenal hyperplasia responsible for Cushing's syndrome. This is a report of an 8 month old child with bilateral nodular adrenal hyperplasia. -
Determination of bone width in malnourished children under 5, and its inter relationship with mid arm muscle thickness, subcutaneous fat thickness and the mid upper arm girth.
Indian J Pediatr. 1992 Mar-Apr;59(2):197-202.Khare M, Shrivastava DK, Puliyel JM.The mid upper arm of 516 malnourished children (one to five years) were studied radiographically for changes in bone width, muscle mass and subcutaneous fat, of malnutrition at different ages. The data was studied by statistical analysis, determining the correlation coefficients of each of the factors. The findings indicate that previous assumptions about the components and the changes of the mid upper arm girth (MUG) in chronic severe malnutrition, were perhaps too simplistic. -
Newer vaccines--to vaccinate or not to vaccinate is the question: ethical and medicolegal issues.
Indian Pediatr. 1998 Aug;35(8):791-5.Puliyel JM. -
The clinical risk index of babies (CRIB) score in India.
Indian J Pediatr. 2002 Nov;69(11):957-60.Khanna R, Taneja V, Singh SK, Kumar N, Sreenivas V, Puliyel JM.OBJECTIVE: To assess the usefulness of clinical risk index of babies (CRIB score) in predicting neonatal mortality in extremely preterm neonates, compared to birth weight and gestation. METHODS: 97 preterm neonates with gestational age less than 31 weeks or birth weight less than or equal to 1500 g were enrolled for the prospective longitudinal study. Relevant neonatal data was recorded. Blood gas analysis results and the maximum and the minimum FiO2 required by babies in first 12 hours of life Read More... -
Who's WHO; Hepatitis B Controversy: Debate in Pediascene
http://tinyurl.co.uk/0eyc accessed 9/7/06 -
The impact of admospheric pollution related haze on vitamin D status of two year olds in Delhi India
Archives of disease in childhood 2001;84:(Suppl 1) A43Mughal Z, Agarwal K, Puliyel J, Upadhyaya P, Berry J, Mawer EB. -
Prediction of mortality by application of PRISM score in intensive care unit.
Indian Pediatr. 2001 Jul;38(7):714-9.Singhal D, Kumar N, Puliyel JM, Singh SK, Sreenivas V.OBJECTIVE: Prediction of mortality by application of Pediatric Risk of Mortality (PRISM) score in Pediatric Intensive Care Unit (PICU) patients under Indian circumstances. DESIGN: Prospective study. SETTING: PICU of a tertiary care multi-specialty hospital. METHODS: 100 sick pediatric patients admitted consecutively in PICU were taken for this study. PRISM score was calculated. Hospital outcome was recorded as (died/survived). The predicted death was calculated by the formula: RESULTS: Of 100 pa Read More... -
Salk vs Sabin controversy
Indian Pediatr. 1987 Aug;24(8):690.Puliyel JM -
BCG vaccination
Indian Pediatr. 1984 Mar;21(3):258.Puliyel J -
Hypertonicity may contribute to overestimation of dehydration in diabetic ketoacidosis
Conference: Second European Pediatric Congress24-7 April 1996. Berlin GermanyPuliyel J, Puliyel M, Hincliff R. -
Hypertonicity in diabetic ketoacidosis: Unexpected biochemical correlates and clinical implications
Conference: Joint Meeting of International Symposium on Diabetes and Endocrine disorders of the young and 4th Asian Symposium of Childhood and Juvenile Diabetes: Chaing Mai Thailand Jan 26-9 1997Puliyel J, Puliyel M, Hincliff R. -
Detection of PEM
Indian Pediatrics 1985;22:249Puliyel JM -
The components of the Mid-Upper-Arm Girth
J of Tropical Pediatrics 1988;34:201Khare M, Shivastava DK, Puliyel J. -
Childhood immunization in developing countries
BMJ 1987;295:1419Varughese S, Puliyel M, Puliyel J -
Hepatitis B immunization: cost calculation in a community-based study in India.
Indian J Gastroenterol. 2004 Jan-Feb;23(1):16-8Sahni M, Jindal K, Abraham N, Aruldas K, Puliyel J.MHepatitis B immunization: cost calculation in a community-based study in India. (REPLY)Keyords: BACKGROUND AND AIM: In India, approximately 65% of mothers deliver at home, and a community-based study evaluating the cost of vaccinating newborns with the first dose of hepatitis B vaccine within 48 hours has not been undertaken previously. This policy planning study was done to evaluate the costs of such immunization in India. METHODS: All mothers delivering in the study area (population 65,000) o Read More... -
Comment: Death of twins after intravenous varicella zoster immunoglobulin.
* Ann Pharmacother. 2005 Dec;39(12):2140; author reply 2140-1.Bhambhani V, Kumar N, Puliyel JM. -
Natural immunity to Haemophilus influenza in Indian children.
Vaccine. 2001 Sep 14;19(32):4592-4.Puliyel JM, Agarwal KS, Abed Abass F.Puliyel JM, Agarwal KS, Abed Abass F. -
Sudden onset profound deafness in association with antiphospholipid antibodies in a child with SLE.
Indian Pediatr. 2000 Nov;37(11):1274-6.Agarwal KS, Puliyel JM, Khanduri U. -
Natural immunity to haemophilus influenza B in India; Implications for a pricing policy for the vaccine .
http://books.google.com/books?hl=en&lr=&id=Z222-Oul_VgC&oi=fnd&pg=PA117&ots=8ZpQ4Bra5p&sig=ExPzsrXM1EOVFl5509wLvi9smkM#PPA117,M1 In Focus on Meningitis Research. Editor Phyllis V. Strong Chapter 7, Nova Biomedical Books New York 2004. Pg 117-129.Samridh Nagar, Jacob M. Puliyel -
Community based retrospective study of sex in infant mortality in India.
BMJ. 2003 Jul 19;327(7407):126Khanna R, Kumar A, Vaghela JF, Sreenivas V, Puliyel JM.OBJECTIVE: To determine whether the imbalance in the sex ratio in India can be explained by less favourable treatment of girls in infancy. DESIGN: Analysis of results of verbal autopsy reports over a five year period. SETTING: Community health project in urban India. MAIN OUTCOME MEASURES: Deaths from all causes in infants aged less than 1 year. RESULTS: The sex ratio at birth was 869 females per 1000 males. The mean infant mortality was 1.3 times higher in females than in males (72 v 55 per 100 Read More... -
Lactate: Creatinine ratio in babies with thin meconium staining of amniotic fluid.
BMC Pediatr. 2006 Apr 20;6(1):13Ojha RK, Singh SK, Batra S, Sreenivas V, Puliyel JM.ABSTRACT: BACKGROUND: ACOG states meconium stained amniotic fluid (MSAF) as one of the historical indicators of perinatal asphyxia. Thick meconium along with other indicators is used to identify babies with severe intrapartum asphyxia. Lactate creatinine ratio (L: C ratio) of 0.64 or higher in first passed urine of babies suffering severe intrapartum asphyxia has been shown to predict Hypoxic Ischaemic Encephalopathy (HIE). Literature review shows that meconium is passed in distress and thin mec Read More... -
Evaluation of pulse-oximetry oxygen saturation taken through skin protective covering.
BMC Pediatr. 2006 May 6;6(1):14James J, Tiwari L, Upadhyay PK, Sreenivas V, Bhambhani V, Puliyel J.ABSTRACT: BACKGROUND: The hard edges of adult finger clip probes of the pulse oximetry oxygen saturation (POOS) monitor can cause skin damage if used for prolonged periods in a neonate. Covering the skin under the probe with Micropore surgical tape or a gauze piece might prevent such injury. The study was done to see if the protective covering would affect the accuracy of the readings. METHODS: POOS was studied in 50 full-term neonates in the first week of life. After obtaining consent from thei Read More... -
Ask the Doc The Hindu
Sunday Magazine The Hindu 30/10/05Puliyel JErb's Palsy, Rubella vaccine, Nocturnal enuresis, Primary complex, Hair on the upper lip in girls, Eating problems -
Smuggling contraband drugs using paediatric
Arch Dis Child. 2006 Jan;91(1):51.Chakrabarty A, Hydros S, Puliyel JM.See last page 51 -
Prone to survive.
Crit Care Med. 2005 Oct;33(10):2448; author reply 2448-9.Sawhney A, Puliyel JM. -
Inadvertent overdosing of neonates as a result of the dead space of the syringe hub and needle.
Arch Dis Child Fetal Neonatal Ed. 2005 Sep;90(5):F444-5.Bhambhani V, Beri RS, Puliyel JM. -
Refractive error at birth and its relation to gestational age.
Curr Eye Res. 2005 Jun;30(6):423-8.Varughese S, Varghese RM, Gupta N, Ojha R, Sreenivas V, Puliyel JM.PURPOSE: The refractive status of premature infants is not well studied. This study was done to find the norms of refractive error in newborns at different gestational ages. METHODS: One thousand two hundred three (1203) eyes were examined for refractive error by streak retinoscopy within the first week of life between June 2001 and September 2002. Tropicamide eye drops (0.8%) with phenylephrine 0.5% were used to achieve cycloplegia and mydriasis. The refractive error was measured in the vertica Read More... -
An indigenous leucocyte esterase test along with Pandy's test for the diagnosis of bacterial meningitis.
Indian Pediatr. 2001 Nov;38(11):1281-6.Srivastava RK, Gupta S, Bhargava M, Kumar N, Upadhyay P, Puliyel JM. -
Screening for Down's syndrome. Ratio of femoral length to tibial length needs to be evaluated extensively.
BMJ. 2002 Jan 12;324(7329):112.Sachdev P, Bahl S, Puliyel JM. -
Overseas Doctor Training Scheme. More visiting registrar posts are needed.
BMJ. 1994 Jul 30;309(6950):338-9.Puliyel J -
Repeated unifocal seizure in post neonatal infants with hypocalcemia.
Indian Pediatr. 2000 Feb;37(2):203-5.Agarwal KS, Beri RS, Puliyel JM. -
Meta-analysis can be statistically misleading
Evidence-Based Medicine 2005;10:130; doi:10.1136/ebm.10.5.130-aJacob M Puliyel, MRCP, MPHIL, MD1 and Vishnubhatla Sreenivas, PhD2 -
Universal immunization with hepatitis B vaccine- what it will cost.
Indian Pediatr. 2000 Jan;37(1):107-10.Puliyel J -
Osmotonicity of acetoacetate: possible implications for cerebral edema in diabetic ketoacidosis.
Med Sci Monit. 2003 Apr;9(4):BR130-3.Puliyel JM.BACKGROUND: Rapid drops in blood glucose and sodium levels during treatment of diabetic ketoacidosis (DKA) can cause a drop in the osmotonicity of plasma, resulting in cerebral edema. Ketone bodies are assumed to move freely in and out of cells, so it is assumed that they do not contribute to the tonicity of plasma or influence fluid shifts. The assumption that ketone bodies do not contribute to osmotonicity has not been tested previously. The experiment described here was done to check if aceto Read More... -
Ultrasonographic femur-tibial length ratio: a marker of Down syndrome from the late second trimester.
Am J Perinatol. 2001 Jun;18(4):217-24.Gupta R, Thomas RD, Sreenivas V, Walter S, Puliyel JM.An observational prospective study reported that newborn babies with Down syndrome (DS) had short upper limbs that reach up to their pelvis. The shortening was most marked in the forearm (the middle segment of the upper limb) and this relative shortening resulted in an alteration of the proximal to middle segment length ratio. This study assumes that there is a similar alteration in the ratio of the lower limb. We propose to study the proximal to middle segment ratio in the lower limb in normal Read More... -
Melas syndrome.
Indian J Pediatr. 1999 Jul-Aug;66(4):621-5.Singh SK, Sarin D, Puliyel JM, Srivastav R, Gupta R, Kumar N, Mathews A.An 11 year old male presented with headache, vomiting and weakness of right side of body. One day after admission he developed right focal seizures. He had 5 previous episodes of stroke, the first at 11 months age. His milestones were normal upto the first episode but subsequent mile stones were delayed. His serum and CSF lactic acids were raised. Muscle biopsy showed ragged red fibres on modified Gomori-trichrome staining. His EEG, CT scan and MRI were normal this time. The child improved spont Read More... -
Acute pancreatitis with cholestatic hepatitis: an unusual manifestation of hepatitis A.
Ann Trop Paediatr. 1999 Dec;19(4):391-4.Agarwal KS, Puliyel JM, Mathew A, Lahoti D, Gupta R.Acute hepatitis A infection is an uncommon cause of pancreatitis in children. To date, only four cases have been reported in the paediatric literature. We report a 7-year-old girl with acute pancreatitis associated with hepatitis A infection who made a satisfactory recovery. The report highlights the CT findings including focal necrosis not previously reported. Because of the extreme rarity of the complication, the four previous reports have also been single case reports. This paper reviews all these cases with a view to elucidating the aetiopathogenesis of the pancreatitis. -
Trichorhinophalangeal syndrome with repeated dislocation of the patella
Clin Genet. 1992 Mar;41(3):139-42.Puliyel JM, Puliyel MM, Varughese S.The trichorhinophalangeal syndrome associated with laxity of the skin and joints has been mistaken for Ehlers-Danlos syndrome (Jones 1988). We report a case of the trichorhinophalangeal syndrome which we mistook for the Larsen syndrome. Literature and published photographs of the Larsen syndrome are reviewed to highlight the similarities between these two entities. These observations may be of value in the genetic mapping of the Larsen syndrome, which perhaps is a contiguous gene syndrome. -
Ellis-van Creveld syndrome in Kerala.
Trop Geogr Med. 1987 Oct;39(4):385-7Puliyel JM, Daniel A, Mathew CH.A case of the Ellis-van Creveld syndrome is described. Emphasis is laid on the probable relation to the frequency of consanguineous marriages among the Hindu community in Kerala. -
A syndrome of keratosis palmo-plantaris congenita, pes planus, onychogryphosis, periodontosis, arachnodactyly and a peculiar acro-osteolysis.
Br J Dermatol. 1986 Aug;115(2):243-8.Puliyel JM, Sridharan Iyer KS.A family with a symptom complex of pes planus, onychogryphosis, palmoplantar hyperkeratosis and periodontosis is reported. A detailed pedigree is given and the mode of inheritance is suggested -
Audit of nurse-led-training for epipen in a District General Hospital.
Allergy. 2006 Aug;61(8):1019-20.Ratnaweera D, von Trilsbach J, Rangasami J, Green DA, Puliyel JMDepartment of Paediatrics, West Middlesex University Hospital, Twickenham Road, Isleworth, Middlesex, UK. A community-based study in the London Borough of Hounslow, which included patients in our District General Hospital (DGH) Paediatric Department, found that most families who had been prescribed adrenaline auto-injectors could not use them properly. This prompted the establishment of a new protocol for doctors and an Allergy Clinic where one nurse was responsible for training all patients. Read More... -
Ask The Doc
The Hindu 27/08/06Puliyel J MAsthma and Convulsions, Milk protein allergy, Nocturnal enuresis (Bed wetting), Growth hormone, Focal seizures. -
Indian association questions plan for hepatitis B immunisation
BMJ 2006;333:621, doi:10.1136/bmj.333.7569.621-cGanapati MudurIndian Medical Association report on Hepatitis B Indian association questions plan for hepatitis B immunisation New Delhi Ganapati Mudur The Indian Medical Association has criticised a government proposal to expand universal immunisation against the hepatitis B virus throughout India, saying that it would be “wasteful spending” on a low priority health problem. In a report sent to the health ministry, the association said that a systematic review of studies indicates that the rate o Read More... -
An initial inquiry into cost-effectiveness of surfactant in India: a pilot randomised controlled trial
Medical Varitas 2006;3: Proof pagesTiwari L, Baijal N, Kumar N, Puliyel JM -
Economic Evaluation Tailored to Promote Vaccine Uptake: How Third World Consumers Can Respond
Expert Rev. Pharmacoeconomics Outcomes Res.2005;5:515-6Arora R, Puliyel JM.“Suppose it were ascertained that every child in the world could be rendered absolutely immune from all disease during its entire life by taking half an ounce of radium to every pint of its milk. The world would be none the healthier, because not even a Crown Prince - no, not even the son of a Chicago Meat King, could afford the treatment. Yet it is doubtful whether doctors would refrain from prescribing it on that ground. The recklessness with which they now recommend wintering in Egypt or at Read More... -
Polio Eradication and the Future for Other Programs:
Indian J Med Res 2007;125:1-4.Puliyel JM, Gupta MA, Mathew JL -
Ask The Doctor
file:///C:/Documents%20and%20Settings/prem/Desktop/Ask.htmJacob M. PuliyelAsthma, Seroflo under four, Poor eating, Slow child. -
Vitamin A deficiency in children under 6 months
Tropical Doctor 2007;37;59-60Sara Varughese -
Ask The Doctor
http://www.hindu.com/mag/2007/07/01/stories/2007070150200600.htmPuliyel JAsthma, inhaled steroids, Bronciolitis, Seroflo -
Systematic Review and Meta-analysis of Prevalence of Hepatitis B in India
Indian Pediatrics 2007;44:663-74Ashish Batham, Dherian Narula, Tanmay Toteja, V Sreenivas*, Jacob M Puliyel.Abstract Objective: To evaluate the point prevalence of Hepatitis B in India. Design: Meta-analysis of data on point prevalence from different parts of the country. Data sources: Searches were made in Medline, Cochrane Library and Best bets and previous reviews. A limited hand search of cross references was also done. Finally a consultation with experts was held to enlarge the references base. Review methods: Studies reporting prevalence of HBsAg were selected. Data from high risk groups were e Read More... -
Research on Hib vaccine 'dubious'
http://www.scidev.net/EditorLetters/index.cfm?fuseaction=readeditorletter&itemid=119&language=1Jacob PuliyelResearch on Hib vaccine 'dubious' * Author: Jacob M Puliyel, M.D. Affiliation: Head of Paediatrics St Stephens Hospital Delhi, India Date: 10 July 2007 I was quoted in the Hib vaccine news story from 4 July (see Hib vaccine could save thousands in Asia), but perhaps due to constraints of column space, I feel justice was not done to what I said. My main argument against the research findings from Bangladesh is not that it does not make economic sense, but that the study Read More... -
Protective efficacy of a monovalent oral type 1 poliovirus vaccine
www.thelancet.com Vol 370 July 14, 2007 Pages 129-30Jacob Puliyel, C Sathyamala, D Banerji.Protective efficacy of a monovalent oral type 1 poliovirus vaccine We the undersigned are shocked and dismayed that the Lancet should have published the paper on the protective efficacy of monovalent oral type 1 poliovirus vaccine by Grassly et al (April 21, p1356)1, having overlooked the serious ethical issues involved. The article describes how the international oversight body on polio eradication recommended the rapid development licensing and introduction of a new monovalent type 1 ora Read More... -
Author's Reply Polio eradication and the future of other programmes
Ind J of Med Res 2007; 125:696-8Gupta MA, Puliyel J -
Outbreak of Coxsackie B4 arthritis among newborns and staff of a neonatal unit.
Trop Doct. 2007 Jul;37(3):188-9.Bhambhani V, Abraham J, Sahni M, Harit AK, Khare S, Puliyel JM.We investigated an outbreak of Coxsackie B4 arthritis in a neonatal unit involving 20 neonates and 12 staff members, over an eight-month period. Laboratory investigations, serology tests, indicate that the outbreak was caused by Coxsackie B4 virus. Contamination of one of the overhead water reservoirs, supplying the nursery, was responsible. After the water tanks were cleaned out, no new cases were reported over five years. -
Estimation of True Incidence of Polio: Overcoming Misclassification Errors due to Stool Culture Insensitivity
Indian Pediatrics 2007;44:596-7Sreenivas V, Puliyel JM -
Sick score
-
Point prevalence of hepatitis B in mother-child dyads in a stratified random sample in an urban resettlement community in Delhi
Ind J Gastroentrology 2007;26:July 193-4Toteja Tanmay, Satyamala C, Chowdhary Sona, Lata Suman, Puliyel JacobPoint prevalence of hepatitis B in mother-child dyads in a stratified random sample in an urban resettlement community in Delhi Toteja Tanmay1, Satyamala C2, Chowdhary Sona1, Lata Suman1, Puliyel Jacob1 1 Department of Pediatrics St Stephens Hospital, Delhi 110 054, India 2 Public Report on Health, Department of Social Welfare, 53 Lodhi Estates, New Delhi, India Correspondence Address: Puliyel Jacob Department of Pediatrics St Stephens Hospital, Delhi 110 054 India puliyel@vsnl.com Read More... -
Cerebral edema in diabetic ketoacidosis with serum sodium below 135 mEq/L
J Pediatr. 2008 Jan;152(1):145-6;Sema A, Puliyel JM.Cerebral edema in diabetic ketoacidosis with serum sodium below 135 mEq/L Hooran et al1 have studied a group of patients with diabetic ketoacidosis (DKA) and cerebral edema (CE) against 2 control groups without CE, one with and the other without hypernatraemia. They suggest that a gradual decrease in plasma glucose and a concomitant increase in serum sodium, decrease the likelihood of CE. This finding takes us a little closer to understanding CE in DKA. However our analysis of their data s Read More... -
Authors reply Cerebral edema in diabetic ketoacidosis with serum sodium below 135 mEq/L
J Pediatr 2008 Jan;152(1):147-9 -
Estimation of true incidence of polio: Some metodological issues.
Ind Pediatrics 2008;45:158-9Rajib Dasgupta, Sanjay Chaturvedi,Estimation of "True Incidence" of Polio: Some Methodological Issues A recent report(1) has claimed that the true incidence of polio (due to wild polio virus) in India was 1625 in 2006 and not 674 as officially notified. The authors’ notions of "true incidence" and "misclassification" call for careful examination as they challenge the sensitivity of Acute Flaccid Paralysis (AFP) surveillance. Our methodological objections are as follows: 1. Computation of p Read More... -
Estimation of true incidence of polio: Some metodological issues. REPLY
Indian Pediatrics 2008; 45:158-159Puliyel J, Sreenivas V.Reply 1. We explicitly stated in our paper that we have assumed that the chance of one of the two stool samples being negative is independent of the result in the other while calculating the ‘false negatives’. Cases of polio may be misclassified as ‘non-polio AFP’ because culture techniques are not perfect, methods used for collection, storage and transport of stool samples are sub-optimal, and viral shedding is not continuous. The fact that the excretion of virus in the stool is Read More... -
Vaccines: Policy for Public Good or Private Profit?
Indian Journal of Medical Research 2008;127:1-3Puliyel JM, Madhavi Y -
Poor nations are being lured into a debt trap
BMJ, May 2008; 336: 974 - 975Jacob M Puliyel and Ashutosh ShrivastavaUnmasking GAVI and Big Pharma: Rethinking Vaccine Access 9 April 2008 Previous Rapid Response Next Rapid Response Top Jacob M. Puliyel, Consultant Pediatrician and Head of Department St Stephens Hospital, Tis Hazari, Delhi 110054 India., Ashutosh Shrivastava Send response to journal: Re: Unmasking GAVI and Big Pharma: Rethinking Vaccine Access We are dismayed that the article �Rethinking global access to vaccines� has been published as an �Ana Read More... -
A Simple Circuit to Deliver Bubbling CPAP.
Indian Pediatr. 2008 Apr;45(4):312-4.Kaur C, Sema A, Beri RS, Puliyel JM.Indian Pediatrics 2008; 45:-312-314 A Simple Circuit to Deliver Bubbling CPAP Charanjit Kaur, Akatoli Sema, Rajbir S Beri and Jacob M Puliyel From the Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054, India. Correspondence to: J M Puliyel, Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054, India. E-mail: puliyel@gmail.com Manuscript received: June 4, 2007; Initial review completed: September 15, Read More... -
Missing Girls in India: Infanticide, Feticide and Made-to-Order Pregnancies? Insights from Hospital-Based Sex-Ratio-at-Birth over the Last Century
http://www.plosone.org/doi/pone.0002224. PLoS ONE 3(5): e2224. doi:10.1371/journal.pone.0002224.Mohit Sahni, Neeraj Verma, D. Narula, Raji Mathew Varghese, V. Sreenivas, Jacob M. PuliyelIntroduction Data from the census of 2001 suggests that there are only 933 women for every1000 men in India [1]. In 1992 Amartya Sen calculated that 37 million women were ‘missing’ in India [2]. The UN in 2001 estimated that there were 44 million missing women in India [3]. Societal bias favoring males is responsible for the situation [4]. This bias manifests as neglect of girls and women resulting in their early death [5], [6], [7], female infanticide [8], [9] and more recently, antenata Read More... -
Calculating prevalence of hepatitis B in India: Using population weights to look for publication bias in conventional meta-analysis
Ind J Pediatr 2009;76:1247-1257Batham A, Gupta MA, Rastogi P, Garg S, Sreenivas V, Puliyel JM -
Retinopathy of prematurity in South Africa: an assessment of needs, resources and requirements for screening programmes
Br. J. Ophthalmol.2008;92:879-882S Varughese, C Gilbert, C Pieper, C Cook. -
A Simple Circuit to Deliver Bubbling CPAP Power point Slide Show
https://slideplayer.com/slide/11000094/Charanjit Kaur, Akatoli Sema, Rajbir S. Beri and Jacob M. Puliyel -
RCPCH Spring Meeting, York, 15th April 2008. Abstract : . International collaboration validating SICK score: a non-invasive severity-of-illness assessment.
Archives of Disease in Childhood 2008; 93 Suppl 1: A10 [paper].Gupta MA, Sahni M, Puliyel JM, Rangasami J, Chakrabarti A, Halstead R*, Green DA, Puliyel A, Sreenivas V. -
Hepatitis B in India: Systematic review & report of the ‘IMA sub-committee on immunization’
Indian J Med Res. 2008;127:494-497Jacob M. Puliyel, Pallav Rastogi & Joseph L. Mathew -
Diabetic ketoacidosis and cerebral edema: The story so far
Abstract sent 20th International Congress of Pediatrics TeheranJ Puliyel1. The Enigma of Death in DKA Death among children being treated for diabetic ketoacidosis (DKA) is something of an enigma: The deaths occur during treatment and has not declined in spite of the use of better human insulins and continuous infusions with accurate syringe pumps. 2. Overestimation of dehydration in DKA At an annual meeting of the British Pediatric Association an elegant paper was presented that suggested that iatrogenic over-hydration was perhaps responsible. The author Read More... -
Incidence of pneumonia is not reduced by pneumococcal conjugate vaccine
Bulletin of the World Health Organization | October 2008, 86 (10) doi: 10.2471/BLT.08.054692 . http://www.who.int/bulletin/volumes/86/10/08-056572.pdfSona Chowdhary & Jacob Puliyelhttp://www.who.int/bulletin/volumes/86/10/08-056572.pdf Incidence of pneumonia is not reduced by pneumococcal conjugate vaccine Sona Chowdharya & Jacob Puliyela a Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110054, India. Correspondence to Jacob Puliyel (e-mail: puliyel@gmail.com). Madhi et al.1 write that the pneumococcal conjugate vaccine (PCV) is an effective instrument for pneumonia prevention in children. This is not strictly true. WHO data2 suggest that Read More... -
Bubbling CPAP Reply in Indian Pediatrics.
Indian Pediatrics 2008;45:942-3Kaur C, Puliyel J -
A primer on health economics for Pediatricians
Recent Advances in Pediatrics 13. Editor Suraj Gupte. Publisher Jaypee Brothers New Delhi Page 261-6Puliyel JM, Anish James Thomas, Kapil Jindal. -
Nasopharyngeal teratoma as a cause of neonatal stridor
Indian Pediatr. 2009 Dec;46(12):1097-8.Tiwari L, Baijal N, Puliyel JM. -
Public Interest Petition (PIL) in Delhi High Court on Vaccines
Delhi High Court. (2009) Writ Petition (Civil) No. 13698 of 2009. Public Interest Litigation. Available at http://delhihighcourt.nic.in/index.html 2009Prashant Bhushan Advocate, Petitioners: Saxena KB, Mittal SK, Banerji D, Imrana Qadeer, Kurien NJ, Priya R, Mira Shiva, Puliyel JM, Dabade G.IN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. 13698 Of 2009 PUBLIC INTEREST LITIGATION A WRIT PETITION IN PUBLIC INTEREST UNDER ARTICLE 226 OF THE CONSTITUTION OF INDIA HIGHLIGHTING HOW IRRATIONAL VACCINES ARE BEING ARBITRARILY INTRODUCED AND PROMOTED BY THE GOVERNMENT AT THE BEHEST OF VACCINE MANUFACTURERS AND OTHER VESTED INTERESTS. Memo of Parties IN THE MATTER OF: DR. K. B. SAXENA (PH.D) FORMER HEALTH SECRETARY, GOVERNME Read More... -
Down's Syndrome: Antenatal Diagnosis
Recent Advances in Pediatrics 13. Jaypee Brothers New Delhi 2003. Editor Suraj Gupte Page 436 - 441Puliyel J., Riju MittalRecent Adv Downs -
Setting the Scene to Blame the GOI for Failure of Polio Eradication
INDIAN PEDIATRICS 2009; 46:184-5Siddharth and Jacob Puliyel -
Antenatal Diagnosis of Downs Syndrome: How Good is State of the Art
Journal Indian Medical Association 2009;107:36-40Mittal R, Varghese RM, Puliyel JM. -
Hypertonicity in diabetic ketoacidosis: unexpected biochemical correlates and clinical implications.
Presented at the Joint Meeting of the International Symposium on Diabetes and Endocrine Disorders of the Young and the 4th Asian Symposium of Childhood and Juvenile Diabetes, Chaing Mai, Thailand, January 6-9, 1997.Puliyel J, Puliyel M, Hincliff R. -
Controlling perinatally acquired Hepatitis B
Ind J of Pediatrics 2001;68:365Abass F, Thomas RT, A Rajkumar, N Gupta, Puliyel J -
Prenatal diagnosis of Down's Syndrome: Use of the Circus Dwarf Sign.
Ind Pediatr 1991;28:1083Puliyel J -
IAP policies,guidelines and recommendations on immunization 2003: Citing the evidence
Pediascene March - June 2004 Pg 16 www.pediascene.comBaijal N, Puliyel JM. -
WHO study suggests low incidence of Hib in india is due to natural immunity
Indian J Med Res 2009;129: 205-207Neeraj Gupta & Jacob PuliyelSir, We congratulate the authors of this meticulous study1. The authors found the incidence of Hib meningitis only 0.007 per cent and they speculate that the population may have ‘natural immunity’ to invasive Hib disease. This paper is published 10 years after the data were obtained. Three years ago an editorial published in the ‘Expert Review Pharmacoeconomics Outcomes Research’, cited this study as an instance of selective non-publication of research2. To understand the inter Read More... -
Vaccine introduction where incidence of Hib meningitis is 0.007%: Decision-making based on health economic or ideology?
Indian J Med Res. 2009;129;339-340Gupta N, Puliyel J. -
Swan-neck sign of the big toe - association with hypocalcaemia.
Trop Doct. 2007 Oct;37(4):238-9.Agarwal KS, Baijal N, Tiwari L, Verma N, Sahni M, Puliyel JM. -
Selling vaccines: Deciding on who can afford HPV
Indian Pediatrics 2009:46;647Aneja H, Puliyel J. -
If OSCE is not a valid test of Clinical Skills- What Next?
The News of the National Board of Examination Volume 1 Number 3 Oct-December, 2005 Page 4. http://www.natboard.edu.in/news_latters/NBE%20BulletinVol.I%20No.3,%20October-Dec%202005.pdfPuliyel Jhttp://www.natboard.edu.in/news_latters/NBE%20BulletinVol.I%20No.3,%20October-Dec%202005.pdf -
PIL about Vaccine: Rejoinder to reply by ICMR
Petitioners on PIL by Professor K B Saxena. Filed by Prashant BhushanIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. 13698 Of 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS REJOINDER AFFIDAVIT ON BEHALF OF THE PETITIONERS TO THE COUNTER-AFFIDAVIT OF RESPONDENT NO. 3 (ICMR) I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephans Hospital, Tis Hazari, New Del Read More... -
Civil Society Activism Hinders Vaccine-introduction in India: Vote for autocracy?
http://www.plosmedicine.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2Ff75e65f0-2b4c-40f7-9c10-93f92d150b35&root=info%3Adoi%2F10.1371%2Fannotation%2Ff75e65f0-2b4c-40f7-9c10-93f92d150b35Prashant Tyagi, Mira Shiva, Jacob PuliyelCivil Society Activism Hinders Vaccine-introduction in India: Vote for autocracy? Posted by Puliyel on 18 Mar 2010 at 11:18 GMT Shearer and colleagues use sophisticated modeling techniques to try and explain why some countries take longer to adopt Haemophilus influenza type b (Hib) vaccine in their national immunization programs (1). A primary premise they make is that the vaccine is beneficial to society. Published evidence of strain shifts and side effects however contradict this ass Read More... -
Understanding the Absolute Risk Reduction from HPV Screening is Crucial
http://www.bmj.com/cgi/eletters/338/apr06_2/b1423#214238Jacob M. Puliyel, Himanshu Aneja, Sona Chowdhary.By happenstance, the week after the BMJ �Short cuts� (1) summarized the paper by Sankaranarayanan et al that HPV testing can reduce cervical- cancer mortality (RR 0.52) (2) the Lancet published its editorial on harms from screening (3). However none of the many reviews of the study on �HPV- testing� questioned the wisdom of author�s suggestion that screening for HPV would be an efficient way to reduce cervical cancer. We hope our letter wil Read More... -
Universal immunization with Hepatitis B: Keeping up with the Joneses
http://www.bmj.com/cgi/eletters/332/7545/804#131729Puliyel J, Amit KumarUniversal vaccination of all in the UK with Hepatitis B vaccine will reduce the yearly incidence of new cases of chronic carriers by a mere 4%. 96% of the burden of disease results from disease in immigrants who will not be helped by universal immunisation in the UK. Although these stark facts are widely known (1), in the space of a little more than a year, we have had two editorials in the BMJ, (authored by individuals with declared conflict of interests) suggesting that the UK government must Read More... -
Universal immunisation with hepatitis B in the UK is not cost beneficial
http://www.bmj.com/cgi/eletters/329/7474/1059#87378S. Hydros, V Sreenivas Puliyel JNicholas J Beeching has succinctly summarized the situation with regards hepatitis B in the UK (1). It is however unclear how he arrived at the conclusion that universal immunization should be preferred in Britain. We have serious concerns about this. An assessment of the data provided, shows an unfavourable cost: benefit ratio. The annotation has drawn heavily on one reference (2). In this paper we will also rely on the same source for most of our calculations, so it is not just a matter of us Read More... -
Non-Academic Science : An Oxymoron
http://www.bmj.com/cgi/eletters/328/7440/597#58014Puliyel JI have been following the discussion on academic medicine, and have been impressed by your global approach. Thus you seem, not to be attempting to revitalize academic medicine in the UK but internationally, and such an approach is most likely to promote the science and health in general. In India research is an essential component of post-graduate training. For the MD, or MS and the DNB (Diplomate of the National Board) it is mandatory to submit a research dissertation or thesis, besides app Read More... -
Demolishing democratic institutions to promote biotechnology
http://www.plosmedicine.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F76eddb74-d498-4996-a22c-ac2e5a5f9ab8&root=info%3Adoi%2F10.1371%2Fannotation%2F76eddb74-d498-4996-a22c-ac2e5a5f9ab8Jacob PuliyelDemolishing democratic institutions to promote biotechnology In our previous comment we had noted that the authors had found that democratic institutions retard introduction of vaccines. We had also written about how data from a local multi-center study was obtained through the ‘Right to Information Act’ (RTI) in India. This data showed the problem of Hib was much lower than what was being projected, to justify introduction of the vaccine in the national programme of immunization. This Read More... -
Pneumococcal vaccination in developing countries: where does science end and commerce begin?
Vaccine. 2009;27:4247-51Mathew JL -
Hyperimmunoglobulin E syndrome with juvenile dermatomyositis and calcinosis. Clin Rheumatol. 2010 Apr 8
Clin Rheumatol. 2010 Apr 8Saikia B, Aneja H, Jain J, Puliyel JM. -
Incomplete reporting of research in press releases: Et tu, WHO?
Indian J Med Res 2010;131:588-9Puliyel JM, Mathew JL, Priya R.Incomplete reporting of research in press releases: Et tu, WHO? Jacob Puliyel Head of Department of Pediatrics, St Stephens Hospital, Delhi, India JL Mathew Assistant Professor of Pediatrics, Advanced Pediatrics Centre, PGIMER, Chandigarh, India Ritu Priya Associate Professor Centre of Social Medicine and Community Health Jawaharlal Nehru University, New Delhi, India Address for correspondence Jacob Puliyel St Stephens Hospital Tis Hazari, Delhi. 110054 India puliy Read More... -
Press release after Bangladesh Hib study
Hib initiative -
WHO press release after Bangladesh Hib study
http://www.who.int/immunization/newsroom/Hib_vaccine/en/ -
Respiratory viruses in acute bronchiolitis in Delhi
Indian Pediatrics 2010;47:342-5. http://indianpediatrics.net/apr2010/342.pdfKaur C, Chohan S, Khare S, Puliyel J. -
CUSUM for monitoring competency: Computer software is useful for bootstrapping and real time CUSUM plotting.
Br J Ophthalmol 2011;95:295e296. doi:10.1136/bjo.2010.188805. http://bjo.bmj.com/content/94/4/445/reply#bjophthalmol_el_9709Ashish Puliyel, Jacob PuliyelCUSUM for monitoring competency: Computer software is useful for bootstrapping and real time CUSUM plotting. We congratulate Salowi and colleagues on their study of the use of CUSUM to monitor competency in cataract extraction (1). However there are two modifications that could make their system more responsive and reliable. Firstly the authors use a CUSUM chart that fluctuates on only one side of the zero line. Traditionally CUSUM charts fluctuate on both sides of the zero line (2,3). Read More... -
NTAGI Recommendations Overlooked Crucial ICMR Data
Ind Pediatrics 2010:47:542-3Pompa Dutta and Jacob M PuliyelWe thank the NTAGI for publishing its recommendation on Hib vaccine in Indian Pediatrics(1) as this journal allows ‘extended peer review’ in its correspondence columns. We are concerned that the technical advisory body has overlooked crucial evidence gathered in studies done by the ICMR while making its recommendations. -
Introducing pentavalent vaccine in the EPI in India: A counsel for caution
Indian J Med Res 132, July 2010, pp 1-3Zubair Lone & Jacob M. PuliyelThe story of how pharmaceutical companies influenced scientists and official agencies like the World Health Organization (WHO) in the recent swine flu scare1 and the saga of the undeclared conflicts of interests of members of the WHO’s Strategic Advisory Group of Experts2 has set off alarm bells around the world. When trusted advisors are less than honest, the potential for harm is great, and the feeling of betrayal is poignant. A similar feeling of sadness and betrayal was evoked by the repor Read More... -
Report of an ad-hoc WHO expert panel to review reports of serious AEFI following administration of pentavalent and other vaccines in Sri Lanka 2008
Papers presented to Delhi High Court by the Government of India on Vaccine Petition of Dr KS Sexana et alWHO experts -
Validation of 'Signs of Inflammation in Children that Kill' (SICK) score for immediate non-invasive assessment of severity of illness
Ital J Pediatr. 2010 Apr 26;36(1):35. [Epub ahead of print]Gupta MA, Chakrabarty A, Halstead R, Sahni M, Rangasami J, Puliyel A, Sreenivas V, Green DA, Puliyel JM.To validate the SICK scoring system's ability to differentiate between individuals with higher and lower probabilities of death Method We performed a one year two-centre prospective evaluation of all children aged between one month and 12 years referred to the Paediatric team at St Stephens Hospital in Delhi and admitted to the Paediatric Department at West Middlesex University Hospital in London. We calculated SICK scores at presentation and correlated them with subsequent in-hospital Read More... -
Demanding Accountability from GAVI and WHO
http://www.bmj.com/cgi/eletters/340/apr20_2/c2004#234904Puliyel JLee and Harmer have highlighted the achievements of GAVI but they have also cited the criticisms leveled against it (1). Their article however would have gone to press before the recent controversy over WHO and GAVI functioning, started in India. This week, the Indian Journal of Medical Research published an article entitled: "Incomplete reporting of research in press releases: Et tu, WHO" (2). The article relates to a press release issued by WHO jointly with GAVI, USAID, and Johns Read More... -
Evidence-based National Vaccine Policy
Indian J Med Res 2010;131: 617-628Y. Madhavi, Jacob M. Puliyel, Joseph L. Mathew, N. Raghuram, Anant Phadke, Mira Shiva, S. Srinivasan, Yash Paul, R.N. Srivastava, A. Parthasarathy, Sunil Gupta, Udaykumar Ranga, V. Vijaya Lakshmi, Nayana Joshi, Indira Nath, C.M. Gulhati, Prabir Chatterjee, Anuradha Jain, Ritu Priya, Rajib Dasgupta, S. Sridhar, Gopal Dabade, K.M. Gopakumar, Dinesh Abrol, M.R. Santhosh, Sadhana Srivastava, S. Visalakshi, Anurag Bhargava, N.B. Sarojini, Devinder Sehgal, Sakthivel Selvaraj & D. BanerjiIndia has over a century old tradition of development and production of vaccines. The Government rightly adopted self-sufficiency in vaccine production and self-reliance in vaccine technology as its policy objectives in 1986. However, in the absence of a full-fledged vaccine policy, there have been concerns related to demand and supply, manufacture vs. import, role of public and private sectors, choice of vaccines, new and combination vaccines, universal vs. selective vaccination, routine immuni Read More... -
“Antivaccine Lobby” replies to the BMJ
BMJ 2010;341 c4001 Page 218K B Saxena, Debabar Banerji, Imrana Qadeer, N J Kurian, Ritu Priya, Mira Shiva, Jacob Puliyel, and Gopal Dabade -
GAVI and WHO: Demanding accountability
BMJ 2010;341:c4081 Pg 266Jacob M Puliyel -
Issue raised about incomplete reporting of research in press release: Response to response
Indian J Med Res 2010;132: 230-233Joseph L. Mathew, J. Puliyel -
Public Interest Petition (PIL) Vaccine case 3rd affidavit and Delhi High Court order of 15/9/10
Prashant Bhushan on behalf of petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. 13698 Of 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephans Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state and affir Read More... -
CPAP Technology: Where Affordability meets Utility
Recent Advances in Pediatrics - Special Volume 21 Neonatology and Intensive Care, Editor Suraj Gupte, Japee Medical publishers Delhi 2011Jacob M.Puliyel, Neeraj Gupta -
Introducing pentavalent vaccine in EPI in India: issues involved. (Response to Editorial Counsel for Caution on Pentavalent Vaccine.)
Indian J Med Res 132, October 2010, pp 450-455Response by J Puliyel and Z Lone to correspondence from T. Jacob John & Jayaprakash Muliyil -
Misrepresenting data : Deception or dogma? (Response to IJMR Editorial on Pentavalent Vaccine: Counsel for Caution)
Indian J Med Res 132, October 2010, pp 463-465Responses By J Puliyel and Z Lone to Correspondence from Jacob John*, Anuradha Bose & Vinohar Balraj -
Development of an indigenous paediatric crash cart based on the ABC of resuscitation.
Trop Doct. 2006 Oct;36(4):216-7.Green DA, Chowdhary S, Tiwari L, Lata S. -
Sri Lankan deaths following Pentavalent vaccine: Acceptable collateral damage?
http://www.bmj.com/cgi/eletters/340/jun29_4/c3508Jacob Puliyel, KB Saxena, Debabar Banerji, Imrana Qadeer, NJ Kurian, Ritu Priya , Mira Shiva and Gopal Dabade.Sri Lankan deaths following Pentavalent vaccine: Acceptable collateral damage? As a group of pediatricians, health care activists, teachers in Public Health and bureaucrats who have championed the cause of universal immunization in India all our working lives, we were taken aback at being described as ‘anti-vaccine’, in the print version of the BMJ (1). We plead for the right to respond in our defense, in the print version. India is a country where 50% of the population, (mostly poor Read More... -
“If they don’t have bread let them take vaccines” - The contemporary Marie Antionette. Unedited response to 'Why fear of vaccination is spelling disaster in the developing world'. Published as; 'India cannot afford to use vaccines that are not cost-effective. Developing countries must spend their budgets wisely to save as many lives as possible'
http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effective. Unedited version of Response to http://www.guardian.co.uk/lifeandstyle/2010/oct/11/vaccination-fears-developing-world-deaths.Jacob M PuliyelPublished title: India cannot afford to use vaccines that are not cost-effective. Developing countries must spend their budgets wisely to save as many lives as possible. http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effective -
India cannot afford to use vaccines that are not cost-effective Developing countries must spend their budgets wisely to save as many lives as possible
# The Guardian, Wednesday 27 October 2010. http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effectiveJacob PuliyelUnabridged version of the article is entitled “If they don’t have bread let them take vaccines” - The contemporary Marie Antionette. It is available at http://jacob.puliyel.com/#paper_224 -
Public Interest Petition (PIL) Vaccine case 4rd affidavit
-
Pediatric Protocols St Stephens Hospital Delhi
Department of Pediatric St Stephens Hospital, DelhiPediatrics Protocols Pediatric Handbook 3rd Edition Department of Pediatrics and Neonatology St Stephens Hospital Tis Hazari Delhi 110054 Preface This protocol was prepared by Dr Neetu Vashisht, building on the work of previous editions and the work of Dr R S Beri, Dr Nirmal Kumar, Dr Vineet Tyagi and Dr Jyotsna James. The First Edition was published in 2003 and the Second Edition in 2004. This third edition has been a long time coming. The 3rd edition Read More... -
Ondansetron-Induced Dystonia, Hypoglycemia, and Seizures in a Child
Ann Pharmacother 2011;45:xxxx. Published Online, 28 Dec 2011, theannals.com, DOI 10.1345/aph.1P332Aneet Patel, Shweta Mittal, Samiksha Manchanda, and Jacob Mammen Puliyel -
An Index of 'Arm-twistability' of Governments Will be Useful
http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/bae6b668-a8fc-4b28-9964-bcac42a473dd&root=info:doi/10.1371/annotation/bae6b668-a8fc-4b28-9964-bcac42a473ddPuliyel JResponse to Glatman-Freedman A, Cohen M-L, Nichols KA, Porges RF, Saludes IR, et al. (2010) Factors Affecting the Introduction of New Vaccines to Poor Nations: A Comparative Study of the Haemophilus influenzae Type B and Hepatitis B Vaccines. PLoS ONE 5(11): e13802. doi:10.1371/journal.pone.0013802 http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013802 Response at http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/bae6b668-a8fc-4b Read More... -
Effectiveness versus efficacy of conjugated pneumococcal vaccine: a systematic review of randomised, controlled trials with meta-analysis examining absolute risk reduction and relative risk
Word Text: Clinical Microbiology and Infection (CMI) and the International Journal of Antimicrobial Agents (IJAA), the official journals of ESCMID and ISC . (Abstract accepted for presentation 9/5/2011 and publicationJ. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3) : 1 Department of Pediatrics St Stephens Hospital Delhi, 2 Department of Pediatrics Post Graduate Institute of Medical Science, (PGI) Chandigarh, 3 Department of Biostatistics All India Institute of Medical Science (AIIMS) DelhiNumbers Needed to Treat (NNT) is a measure of the effectiveness. In the context of newer vaccines it is good to ask how many children need to be vaccinated so that one life is saved - the NNT of the vaccine. This is sometimes called the Numbers Needed to Vaccinate (NNV) The next question is related to the cost: How much does it cost to vaccinate one child with this new vaccine. Once we have these 2 figures we can easily calculate the cost per life saved. We did a meta analysis (a study Read More... -
Effectiveness versus efficacy of conjugated pneumococcal vaccine: a systematic review of randomised, controlled trials with meta-analysis examining absolute risk reduction and relative risk
21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 27th International Congress of Chemotherapy (ICC) 07.05.2011 - 10.05.2011J. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3) : 1 Department of Pediatrics St Stephens Hospital Delhi, 2 Department of Pediatrics Post Graduate Institute of Medical Science, (PGI) Chandigarh, 3 Department of Biostatistics All India Institute of Medical Science (AIIMS) DelhiNumbers Needed to Treat (NNT) is a measure of the effectiveness. In the context of newer vaccines it is good to ask how many children need to be vaccinated so that one life is saved - the NNT of the vaccine. This is sometimes called the Numbers Needed to Vaccinate (NNV) The next question is related to the cost: How much does it cost to vaccinate one child with this new vaccine. Once we have these 2 figures we can easily calculate the cost per life saved. We did a meta analysis (a study of all th Read More... -
Evidence Based Medicine: Making It Better
Economic & Political Weekly EPW april 2, 2011 vol xlvi no 14. Page 23-26 http://epw.in/epw/uploads/articles/15901.pdfJacob M. PuliyelEvidence Based Medicine: Making It Better Jacob M Puliyel MD MPhil Head of Pediatrics St Stephens Hospital Delhi 110054 Puliyel@gmail.com Phone 09868035091 Abstract Evidence Based Medicine (EBM) began as a 'bottom-up' paradigm that taught residents to search the literature for the best available evidence and to critically appraise it for making patient care decisions. As its popularity increased, there evolved a huge market for readymade EBM summaries and revi Read More... Ethical use of newer vaccines
Indian Medical Association National Conference Jaipur 27 December 2010Jacob Puliyelhttp://www.youtube.com/watch?v=vGvu1sQfxAw http://www.youtube.com/watch?v=elHP06rJvp8 http://www.youtube.com/watch?v=ib-Z9iPRI9s-
Effectiveness versus efficacy of conjugated pneumococcal vaccine: a systematic review of randomised, controlled trials with meta-analysis examining absolute risk reduction and relative risk
You have free access to this content Clinical Microbiology and InfectionVolume 17, Issue Supplement s4, Article first published online: 4 MAY 2011 http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2011.03558.x/pdf Page 299 P1442J. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3)Effectiveness versus efficacy of conjugated pneumococcal vaccine: a systematic review of randomised, controlled trials with meta-analysis examining absolute risk reduction and relative risk Objectives: Use of the 7-valent pneumococcal conjugate vaccine (PCV7) resulted in reduction in vaccine serotypes invasive pneumococcal disease (IPD). However, IPD due to serotypes not included in the PCV7 increased in frequency. This prompted the introduction of a 13 valent vaccine. Previous systematic rev Read More... -
Public Interest Petition (PIL) Vaccine case 5th affidavit 5/5/11
Prashant Bhushan on behalf of petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. 13698 Of 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephens Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state and affir Read More... -
Cost of pneumococcal vaccine underestimated ten-fold.
Hum Vaccin. 2011 May 1;7(5). [Epub ahead of print]Puliyel JacobCost of pneumococcal vaccine underestimated ten-fold I commend Professor Light1 for his article on the pneumococcal AMC. His excellent article was however marred by a typographic error that overestimates the benefit from the vaccine at least ten-fold. I hope you will permit it to be corrected so the scientific record is accurate. The author quotes a paper by Madhi et al to suggest that 360 lives are saved per 100,000 vaccinated.2 This is a mistake. Madhi et al., in fact suggests only 360 “ca Read More... -
Introducing pentavalent vaccine in EPI in India: A counsel for prudence in interpreting scientific literature Author's response
Indian J Med Res 133, May 2011, pp 560-563Lone Z, Puliyel JSir, We thank Gupta et al1 for responding to our editorial. Perhaps they have written the letter before the correspondences of Drs Madhavi & Raghuram2, Drs John & Muliyil3 and our response appeared in print. All their questions have been answered in response to the letters above and we will be hard pressed to answer these questions without simply repeating ourselves. The points they make are: 1. We should not have used under-2 morbidly statistics on the under 5 population. The an Read More... -
Sex Ratio at Birth in India, Its Relation to Birth Order, Sex of Previous Children and Use of Indigenous Medicine
PLoS ONE | www.plosone.org June 2011 | Volume 6 | Issue 6 | e20097 http://dx.plos.org/10.1371/journal.pone.0020097.Samiksha Manchanda*, Bedangshu Saikia, Neeraj Gupta, Sona Chowdhary, Jacob M. PuliyelSex Ratio at Birth in India, Its Relation to Birth Order, Sex of Previous Children and Use of Indigenous Medicine Samiksha Manchanda*, Bedangshu Saikia, Neeraj Gupta, Sona Chowdhary, Jacob M. Puliyel Department of Neonatology and Pediatrics, St Stephen Hospital, Delhi, India Abstract Objective: Sex-ratio at birth in families with previous girls is worse than those with a boy. Our aim was to prospectively study in a large maternal and child unit sex-ratio against previous birth sex and use Read More... -
Nebulized Hypertonic-Saline vs Epinephrine for Bronchiolitis: Proof of Concept Study by Cumulative Sum (CUSUM) Analysis
Indian Pediatr. 2012;49:543-7NEERAJ GUPTA, *ASHISH PULIYEL, AYUSH MANCHANDA AND JACOB PULIYELNebulised Hypertonic-Saline against Epinephrine for Bronchiolitis: Proof-of-Concept Study by Cumulative Sum (CUSUM) Analysis NEERAJ GUPTA, *ASHISH PULIYEL, AYUSH MANCHANDA AND JACOB PULIYEL From the Department of Pediatrics and Neonatology, St Stephen�s Hospital, Delhi, India; and * Tech Guru gonzoBuzz, Singapore. Correspondence to: Dr Neeraj Gupta, Registrar, Department of Pediatrics, St Stephen�s Hospital, Tis Hazari, Delhi 110 054, India. drneeraj79@yahoo.co.in Received: M Read More... -
Case Report: Trypanosoma lewisi or T. lewisi -like Infection in a 37-Day-Old Indian Infant
Am. J. Trop. Med. Hyg., 85(2), 2011, pp. 221–224 doi:10.4269/ajtmh.2011.11-0002Archana Verma , Samiksha Manchanda , Nirmal Kumar , Archna Sharma , Masha Goel , Partha Sarathi Banerjee , Rajat Garg , Brahma Pal Singh , Fatima Balharbi , Veerle Lejon , Stijn Deborggraeve , Udai Veer Singh Rana , and Jacob Puliyel *221 Am. J. Trop. Med. Hyg., 85(2), 2011, pp. 221–224 doi:10.4269/ajtmh.2011.11-0002 Copyright © 2011 by The American Society of Tropical Medicine and Hygiene INTRODUCTION Trypanosomes are flagellated protozoan parasites infecting a wide range of animals and man. Human infection with Trypanosoma brucei ( T.b.) gambiense or T.b. rhodesiense causes African sleeping sickness (African trypanosomiasis) and Trypanosoma cruzi causes Chagas disease (American trypanosomiasis). These infection Read More... -
Should India launch a national immunisation programme against rotavirus? No
BMJ 2012;345:e7832 http://bmj.com/cgi/content/full/bmj.e7832?ijkey=zi5IcOwY7LAyzja&keytype=refJacob Puliyel, Joseph L MathewHead to Head Should India launch a national immunisation programme against rotavirus? No BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e7832 (Published 30 November 2012) Cite this as: BMJ 2012;345:e7832 Epidemiologic studies Child health Immunology (including allergy) Neurogastroenterology Infectious diseases Article Related content Article metrics Jacob M Puliyel, consultant paediatrician1, Joseph L Mathew, associate professor2 Au Read More... -
Advertising standards and vaccine promotion
http://blogs.bmj.com/bmj/2012/12/20/jacob-puliyel-advertising-standards-and-vaccine-promotion/Jacob PuliyelUntil last week few people in India had heard of the existence of the Advertising Standards Council of India (ASCI). Suddenly in the newspapers on the 15 December 2012 the ASCI was prominently featured. The story was about an advertisement for rotavirus vaccine on TV channels in many parts of the country. Set up in 1985 as a self regulatory voluntary organisation of the advertising industry, ASCI’s code in advertising is now part of the “advertisement code,” and its violation is now viola Read More... -
Merchants and Mercenaries: The Lost Maya Civilization
http://www.webmedcentral.com/wmcpdf/Article_WMC003904.pdfJacob PuliyelMerchants and Mercenaries: The Lost Maya Civilization Between 1 December and 5 December in Cancun Mexico – the heart of Maya land, Zing Conferences organized the Mathematical and Computational Medicine Conference 2012. (1,2) In the spirit of the Christmas Issue of the WebMedCentral, it is appropriate that I write about the venue and the perspective it provided for a congress on Mathematical and Computational Medicine, that I do not discuss the computational problems in understanding the thr Read More... -
Pseudohypoparathyroidism with Diabetes Mellitus and Hypothyroidism
Indian Pediatrics 2012;49:989-991http://www.indianpediatrics.net/dec2012/989.pdfBEDANGSHU SAIKIA, SUNAINA ARORA AND JACOB M PULIYELCASE REPORT Pseudohypoparathyroidism with Diabetes Mellitus and Hypothyroidism Bedangshu Saikia, Himanshu Aneja, Sunaina Arora, Jacob M Puliyel. Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054, India. CORRESPONDING AUTHOR: Dr Bedangshu Saikia Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054, India Email: bedangshu@gmail.com Ph: +919212770581 Fax: +91-11-23932412 KEYWORDS: Albright's Hereditary Osteodystrophy (AHO), Pseudohypoparathyroidism Read More... -
Pentavalent study in Kerala
http://blogs.bmj.com/bmj/2012/12/21/jacob-puliyel-on-the-pentavalent-study-in-kerala/Jacob PuliyelThe 14 December 2012 marked the end of a year long pentavalent vaccine study in Kerala, India. Kerala is a small state in the south with some of the best healthcare indicators in the country. The pentavalent vaccine is to replace the diphtheria, pertussis, and tetanus (DPT) vaccine and combines H influenza B and Hepatitis B with the older trivalent vaccine. The pentavalent vaccine study in neighboring Tamil Nadu has about a month more to run. The final results may take another three months to Read More... -
Response to Cunliffe et al Should India launch a national immunisation programme against rotavirus?
http://www.bmj.com/content/345/bmj.e7832?tab=responsesJacob Puliyel, Joseph L MathewWe thank Cunliffe and his co-authors from PATH and the Bill and Melinda Gates Foundation (B&MGF) for their response to our article. We note however, that they employ a straw-man fallacy to support rotavirus vaccine introduction globally. Evidence from the Cochrane meta-analysis has demonstrated that rotavirus vaccine does not to reduce childhood mortality. (1) This makes it difficult to defend the promotion of this expensive vaccine in developing countries – being pushed as a ‘key ste Read More... -
Vaccine Policy and Advance Market Commitments
November 5, 2011 vol xlvI nos 44 & 45 EPW Economic & Political Weekly Pages 18-9Jacob M. PuliyelCOMMENTARY november 5, 2011 vol xlvI nos 44 & 45 EPW Economic & Political Weekly 18 Vaccine Policy and Advance Market Commitments Jacob Puliyel The new National Vaccine Policy Draft 2011 by the Union Ministry of Health and Family Welfare comes out openly in favour of public-private partnerships and suggests flexible governing and funding mechanisms to support vaccine development in the PPP mode. This article argues that our vaccine policy must look into the health of the children in Read More... -
Public Interest Petition (PIL) Vaccine case 6th affidavit 14/11/11
Prashant Bhushan on behalf of the petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) C.M. No. OF 2011 IN WRIT PETITION (CIVIL) No. 13698 OF 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS APPLICATION FOR DIRECTION ON BEHALF OF THE PETITIONERS UNDER SECTION 151 CPC To, The Hon’ble Chief Justice of Delhi And His Hon’ble Companion Justices of Read More... -
Occupy Medicine: Vaccines for 99% versus profits for the 1%
http://www.youtube.com/watch?v=AWE_L5-mGWE&feature=bf_prev&list=ULPIxogXq35bk&lf=mfu_in_orderJacob PuliyelAvailable on youtube at address in referenceIn acknowledgement of the world wide “Occupy Wall Street’ movement this talk is on ‘Occupy Medicine’ Specifically it is about vaccines for 99% versus profits for the 1% There is the story of a sales person who went to a villager and asked to buy a donkey. The villager said. I have a donkey. I need the money. You can have my donkey. It will cost $100. The salesman paid the money and the villager promised to deliver the donkey on the followi Read More... -
Adverse events following Immunization (AEFI) Causality Assessment WHO 2005 Brighton Classification
http://www.rho.org/files/rb3/AEFI_Causality_Assessment_WHO_2005.pdfhttps://brightoncollaboration.org/public/who-we-are/our-story.html Page not found! WHO Aide-Mémoire on AEFI causality assessment - http://www.who.int/vaccines-documents/DocsPDF05/815.pdf Page not found The WHO Has removed the Brighton Classification from it's web site it appears. The classification is available still at http://www.rho.org/files/rb3/AEFI_Causality_Assessment_WHO_2005.pdf In case this page is removed it is available on this website -
National Polio Surveillance India data 2000 -2010 NPSP Polio surveillance data on Acute Flaccid Paralysis (AFP) and non-polio AFP and Demographic data
http://bit.ly/polio-afpJ. Puliyel, N.Vashisht, V. SreenivasThe data on acute flaccid paralysis (AFP), polio and non-polio AFP and number of polio rounds in each state in each year from 2000 to 2009 were from the National Polio Surveillance web site (http://www.npspindia.org/bulletin.pdf). a) Data on numbers of polio rounds during the year 2003 was incomplete. b) When different areas within a state received different number of doses, the arithmetic mean number of doses was taken as the representative dose for that state. 2. Per capita income w Read More... -
Public Interest Petition (PIL) Vaccine case 7th affidavit 14/02/12
Prashant Bhushan on behalf of the petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) C.M. No. 18416 of 2011 IN Writ Petition (Civil) No. 13698 Of 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS BRIEF REJOINDER AFFIDAVIT ON BEHALF OF THE PETITIONERS TO THE AFFIDAVIT FILED BY THE UNION OF INDIA I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen, Head, Dept. of Pediatrics, St. Stephens Hospi Read More... -
Polio programme: let us declare victory and move on
Indian Journal of Medical Ethics Vol IX No 2 April - June 2012 Page 114-7. http://www.issuesinmedicalethics.org/pdfs/202co114.html.pdfNeetu Vashisht, Jacob PuliyelTITLE: Polio programme: let us declare victory and move on AUTHORS: Neetu Vashisht1, Jacob Puliyel1 AFFILIATION: Department of Paediatrics, St Stephens Hospital, Delhi 110054 INDIA Author for correspondence: Jacob Puliyel: e-mail puliyel@gmail.com Abstract It was hoped that following polio eradication, immunization could be stopped. However the synthetesis of polio virus in 2002, made eradication impossible. It is argued that getting poor countries to expend their scarce resources on a Read More... -
Introducing Pentavalent Vaccine in India: How Public Interest Litigation Forced a Re-evaluation of the Evidence ENGLISH VERSION of article published in Turkish language
Turkish Medical Association's journal Turkish Medical Association's journal ISSN 1300-4387 Community and Physician 2012 Volume 27 (1) Page 75-80Puliyel JacobIntroducing Pentavalent Vaccine in India: How Public Interest Litigation Forced a Re-evaluation of the Evidence The Istanbul Experience – Natural Immunity In the year 2000 researchers from Turkey contradicted conventional wisdom about Haemophilus influenzae type b (Hib) infection when they suggested that infants in Istanbul had high concentrations of maternally transferred anti-polyribosylribitol phosphate antibodies (anti-PRP) and they acquired natural active immunity at an early age Read More... -
Of Micro-organisms and Men: Immunity and Vaccines Malayalam article
Chandrika 14 -20 April 2012Puliyel JacobOf Micro-organisms and Men: Immunity and Vaccines The best laid schemes of mice and men- Often go awry John Steinbeck. 1937 There are billions of micro-organisms in our environment. Some have a symbiotic relationship with us, meaning that the relationship between man and the micro-organism are mutually beneficial. Thus there are bacteria resident in our gut, that eats some of the food we have eaten, but in return they make useful vitamins for us to absorb and use. If we kill these harmless Read More... -
Of Micro-organisms and Men: Immunity and Vaccines English version of Malayalam article
Chandrika 14 -20 April 2012. English version of Malayalam articleJacob PuliyelOf Micro-organisms and Men: Immunity and Vaccines The best laid schemes of mice and men- Often go awry John Steinbeck. 1937 There are billions of micro-organisms in our environment. Some have a symbiotic relationship with us, meaning that the relationship between man and the micro-organism are mutually beneficial. Thus there are bacteria resident in our gut, that eats some of the food we have eaten, but in return they make useful vitamins for us to absorb and use. If we kill these harmless Read More... -
Congenital Dengue and Myocarditis: A Case Report and Systematic Review of Literature
Infectious Diseases in Clinical Practice: May 2012 - Volume 20 - Issue 3 - p 180–181Sharma, Richa DCH; Parwal, Natwar DCH; Kumar, Nirmal MD; Puliyel, Jacob M. MDAbstract We report a newborn with congenital dengue infection and cardiomyopathy. Congenital dengue is known to occur owing to vertical transmission of the virus from an infected mother to her baby through the placenta. Dengue-related cardiomyopathy has been reported previously. This is arguably the first time cardiomyopathy is being reported in the context of congenital dengue. A systematic review of literature on congenital dengue as cited in Pubmed is also presented. (C) 2012 Lippincott W Read More... -
Caution needed in using oral polio vaccine beyond the cold chain: Vaccine vial monitors may be unreliable at high temperatures
Indian J Med Res 135, April 2012, pp 36-38Ashutosh Shrivastava, Neeraj Gupta, Pramod Upadhyay & Jacob PuliyelBackground & objectives: Stabilized live attenuated oral polio vaccine (OPV) is used to immunize children up to the age of five years to prevent poliomyelitis. It is strongly advised that the cold-chain should be maintained until the vaccine is administered. It is assumed, that vaccine vial monitors (VVMs) are reliable at all temperatures. VVMs are tested at 37°C and it is assumed that the labels reach discard point before vaccine potency drops to >0.6 log10. This study was undertake Read More... -
Identifying Hypertension using Centile Charts: Overcoming the Problem of Blood Pressure Variability
http://adc.bmj.com/search?fulltext=Identifying+Hypertension+using+Centile+Charts%3A+Overcoming+the+Problem+of+Blood+Pressure+Variability&resourcetype=HWELTR&submit=yesJacob Puliyel, Pediatrician Prabhjeet Kaur, Akanksha Jain, Zainab Golwala, Hardik Shah, Lokesh TiwariIdentifying Hypertension using Centile Charts: Overcoming the Problem of Blood Pressure Variability Jacob Puliyel, Pediatrician Prabhjeet Kaur, Akanksha Jain, Zainab Golwala, Hardik Shah, Lokesh Tiwari St Stephens Hospital Delhi We commend Wu et al for their work on blood-pressure-ratios. Up until now hypertension was defined using statistically derived limits based on gender, age and height specific norms. The formulation of Wu et al permits assessments of adverse effects at d Read More... -
SOP GoI AEFI
-
Public Report on Health Some Key Findings and Policy Recommendations
Economic & Political Weekly EPW may 26, 2012 vol xlviI no 21 Pages 43-54C Sathyamala, N J Kurian, Anuradha De, K B Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Jacob Puliyel, Claire Noronha, Meera Samson -
Radiological Appearance of Molars: Do they consistently identify babies of 33-36 weeks gestation?
Journal of Clinical and Diagnostic Research. 2012 June, Vol-6(5): 863-866Akatoli Sema, Rajeev Sethi, V K Bhatia, Jacob PuliyelRadiological Appearance of Molars: Do they consistently identify babies of 33-36 weeks gestation? Akatoli Sema Rajeev Sethi* V K Bhatia** Jacob Puliyel Department of Pediatrics, St Stephens Hospital, Delhi *Department of Radiology, St Stephens Hospital, Delhi **Indian Agricultural Statistical Research Institute, Pusa Institute, Delhi Running Title: Molar teeth and gestational age Key Words: Ballard’s score, antenatal ultrasound age, bone age, tooth age, small f Read More... -
Public Interest Petition (PIL) Vaccine case 8th affidavit 23/07/12
Writ Petition (Civil) No. 13698 of 2009 PUBLIC INTEREST LITIGATIONPrashant Bhushan on behalf of the petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. 13698 of 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. …PETITIONERS VERSUS UNION OF INDIA & ORS. …RESPONDENTS SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen, Head, Dept. of Pediatrics, St. Stephens Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state and affirm as Read More... -
Noel Narayana Report
G.O. (Rt) No 3678/2011H&FWD dated 20/10/2011 -
NTAGI draft minutes meeting of 18.5.2012
-
CUSUM CTN Opiod
-
CUSUM Estrogen Analysis
-
Monitoring RCT using CUSUM Can Save Lives
Conference Abstract: Mathematical and Computational Medicine Conference 2012Signe Svane, Ellen Marie Møldrup, Ashish Puliyel and Jacob Puliyel*Monitoring RCT using CUSUM Can Save Lives Signe Svane,a Ellen Marie Møldrup,a Ashish Puliyelb and Jacob Puliyelc* a Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Denmark. b #07-130, GonzoBuzz LLP, Singapore 350139 c Department Pediatrics, St Stephens Hospital, Delhi, 110054,India. Cumulative sum (CUSUM) is a statistical technique used in industry for quality control. Objective: The aim of this study is to test if CUSUM can be useful in the context of random Read More... -
Compensation for Victims of Clinical Trials: A Discussion on How Current Indian Rules and Guidelines are Hurting India
Journal of Clinical and Diagnostic Research. 2012 October, Vol-6(8): 1367-1368. DOI: 10.7860/JCDR/2012/4944.2389. http://www.jcdr.net/articles/pdf/2389/jcdr-6-1367.pdfJacob PuliyelAccording to the amended Drugs and Cosmetics Rules of the Government of India, participants in clinical trial are entitled to medical treatment and financial compensation in the event of permanent injury or death, but the quantum of compensation is to be decided by same Ethics Committee that sanctioned the trial in the first place. If there is a dispute regarding the amount of compensation the injured party may appeal again to the Ethics Committee for a review and reconsideration. The decision o Read More... -
Public Interest Petition (PIL) Vaccine case 9th affidavit 23/07/12
Writ Petition (Civil) No. 13698 of 2009 PUBLIC INTEREST LITIGATIONPrashant Bhushan on behalf of the petitioners -
Public Interest Petition (PIL) Vaccine case Government affidavit 20/12/12
Govt of India -
Prone to survive and the priority rule in science
Medical Science Monitor http://www.medscimonit.com/download/index/idArt/889695Jacob PuliyelProne to survive and the priority rule in science Jacob Puliyel Corresponding Author: Jacob Puliyel, e-mail: puliyel@gmail.com Source of support: None In 2005 we published the first study to show that mortality can be reduced by prone ventilation [1]. This study followed the large trial by the Prone-Supine Study Group of Gattinoni and colleagues published in the NEJM in 2001 [2] and another in 2005 that failed to show benefit [3]. We have speculated that the earlier trials failed to show Read More... -
The unfortunate story of 37 deaths from a 'good vaccine'
http://news.yahoo.com/unfortunate-story-37-deaths-good-vaccine-083414585.htmlJacob PuliyelThe unfortunate story of 37 deaths from a ‘good vaccine’ (Comment, Special to IANS) On October 11, two children died in Kashmir after receiving the Pentavalent vaccine, taking to six the total deaths there in one week and to eight the deaths over the last three weeks. According to reports appearing in local newspapers, the deaths were said to be an allergic reaction to the vaccine. These deaths come on the heels of a press release from the health ministry on October 10 that a committee t Read More... -
Authors response 2. Re: Should India launch a national immunisation programme against rotavirus? No
http://www.bmj.com/content/345/bmj.e7832/rr/622915Joseph L. Mathew, Jacob PuliyelAuthors response 2. Re: Should India launch a national immunisation programme against rotavirus? No 3 January 2013 We thank Batik for responding to our paper on the rotavirus vaccines, and raising two distinct issues. The first relates to the efficacy of rotavirus vaccines. We would like to reiterate that the Cochrane review clearly shows that both RV1 and RV5 vaccines did not have any impact on mortality as compared to placebo, in WHO-defined low-mortality as well as high-mortality countries Read More... -
Concern about deaths following Pentavalent Vaccine – making each death count.. Letter to Health Secretary and Corrections
Professor BM Hegde, MD, PhD (Hon. Causa), FRCP (London), FRCP (Edinburgh), FRCP (Glasgow), FRCPI (Dublin), FACC, FAMS. Former Vice Chancellor, Manipal University, Manipal. Former Director-Professor and Dean, Kasturba Medical College, Mangalore. Visiting Professor of Cardiology, University of London between 1982 and 2005, Affiliate Professor of Human Health, University of Northern Colorado, USA. Vikas Bajpai PhD Centre for Social Medicine and Community Health, Jawaharlal Nehru University, Delhi Professor Amitav Banerjee Professor Community Medicine, Dr D Y Patil Medical College, Poona J P Dadhich MD Consultant Pediatrician, New Delhi. Arun Gupta MD FIAP Pediatrician, Member, Prime Minister's Council on India's Nutrition Challenges, Convener, Alliance Against Conflict of Interest(AACI) Professor K P Kushwaha Professor & Head of Pediatrics, BRD Medical College, Gorakhpur. UP. R Lodha Associate Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi Professor S K Mittal Formerly Professor of Pediatrics, MAMC Delhi, Head of Pediatrics, Pushpanjali Crosslay Hospital, Delhi Professor Ritu Priya, Professor Centre of Social Medicine and Community Health Jawaharlal Nehru University New Delhi-110067 Jacob Puliyel MD MRCP M Phil Head of Pediatrics, St Stephens Hospital, Delhi Member National Technical Advisory Group on Immunization (NTAGI) Dhiraj Shah MD Reader in Pediatrics, University College of Medical Sciences, Delhi. Professor S Srinivasan MD Formerly Director-Professor of Pediatrics, JIPMER, PondicherryTo The Health Secretary Ministry of Health and Family Welfare Nirman Bhawan New Delhi January 15, 2013 Sir Subject: Concern about deaths following Pentavalent Vaccine – making each death count. We, a group of academicians, professors and teachers of public health and pediatrics, would like to draw your attention to the pattern of adverse events and deaths from the newly introduced Pentavalent vaccine (DPT+ Hib + Hep B). Pentavalent vaccine was introduced in Kerala and Tamil Nadu Read More... -
Author reply to response from Drs Phadke and Pramila 6 February 2013 Re: “Antivaccine Lobby” replies to the BMJ. K B Saxena, Debabar Banerji, Imrana Qadeer, N J Kurian, Ritu Priya, et al. 341:doi:10.1136/bmj.c4001
http://www.bmj.com/content/341/bmj.c4001/rr/629317Jacob PuliyelAuthor reply to response from Drs Phadke and Pramila 6 February 2013 Re: “Antivaccine Lobby” replies to the BMJ. K B Saxena, Debabar Banerji, Imrana Qadeer, N J Kurian, Ritu Priya, et al. 341:doi:10.1136/bmj.c4001 We thank the doctors Phadke and Pramila for their response to our article. They raise 4 points which I will address individually a) Disease burden in the population. We have stated that the Minz study has found that the under five incidence of Hib meningitis is 7.1/ Read More... -
Author response to Peter J Flegg Re: “Antivaccine Lobby” replies to the BMJ
http://www.bmj.com/content/341/bmj.c4001/rr/629565Jacob PuliyelWe appreciate the comment by Dr Peter Flegg that deaths following immunization do not always imply a cause and effect relationship. I know more about the deaths in India following Pentavalent vaccine and will base my response on that experience. The autopsy reports suggest hypersensitivity reaction in many of the cases. There is no test that can be performed on the vials to look for the hypersensitivity reaction. We depend on the Brighton Classification of AEFI to confirm causation. If Read More... -
Addendum to the response of the Author - for the record
http://www.bmj.com/content/341/bmj.c4001/rr/630682Jacob PuliyelAddendum to the response of the Author - for the record 12 February 2013 In view of the interest and responses to the controversy raised by the deaths following immunization with Pentavalent vaccine in India, I would like to update the earlier response. Intention of NTAGI to Study AEFI Drs Phadke and Menon suggest that the NTAGI introduced Pentavalent vaccine in just two States, because “simultaneous nationwide rollout (would have been) logistically challenging.” In our response we Read More... -
Author response to Flegg: Pentavalent vaccine death-rate is 70 times the SIDS rate of the USA
http://www.bmj.com/content/341/bmj.c4001/rr/631967Jacob PuliyelAuthor response to Flegg: Pentavalent vaccine death-rate is 70 times the SIDS rate of the USA 19 February 2013 I thank Dr Peter Flegg for his continued interest in our paper and our response to the comments made by him. I am however surprised that he has not heard of skin testing for sensitivity to penicillin. The link here refers to a ‘Mayo Clinic’ article about skin testing in this context, written without medical jargon such that non-medical health policy planners can also understand Read More... -
Pentavalent Vaccination and the Infant Mortality Rate
http://www.bmj.com/content/341/bmj.c4001/rr/632448Jacob PuliyelPentavalent Vaccination and the Infant Mortality Rate 22 February 2013 The rapid response section of the BMJ promises to publish anything that contributes to the discussion. Repeating what I have said previously does not contribute anything new, but I hope I can clarify some of the points Dr Fleggs brings up in his last posting. The comparison with IMR The Pentavalent vaccine is being promoted in many Asian countries to reduce mortality in children. I wrote (posted 19/2/13) that the va Read More... -
Jacob Puliyel on the All India centralised entrance test
http://blogs.bmj.com/bmj/2013/03/08/jacob-puliyel-on-the-all-india-centralised-entrance-test/Jacob PuliyelJacob Puliyel on the All India centralised entrance test 8 Mar, 13 | by BMJ Group jacob_puliyelFinal year medical students in the UK currently face an uncertain future as they wait to find out what foundation school place they have been allocated following the muddled “situational judgement test” (SJT). They can take cold comfort in the fact that at least they do not have to do the All India Centralised Entrance Test (CET) that students in India have to take. There are far more cand Read More... -
Bending the truth ostensibly for public good: The case of the pneumococcal conjugate vaccine
Medical Journal of Dr. D.Y. Patil University | January-March 2013 | Vol 6 | Issue http://www.mjdrdypu.org/temp/MedJDYPatilUniv613-3047544_082755.pdfJacob PuliyelMedical Journal of Dr. D.Y. Patil University | January-March 2013 | Vol 6 | Issue 1 3 The Pune Mirror of the 26 th of August 2012 reports that the Indian Academy of Pediatrics (IAP) has declared that pneumonia is a leading cause of death (responsible for 410,000 childhood deaths annually) and recommended that the Government of India should include free vaccines for pneumonia and rotavirus in their immunization schedule. The reporter noted that the IAP’s 2-day training program at the Read More... -
Minutes Core Committee on Vaccines.doc - Minutes Core Committee on Vaccines.
http://www.icmr.nic.in/minutes/Minutes%20Core%20Committee%20on%20Vaccines.pdfGovernment of India Core CommitteeData on disease surveillance in Kerala for 1999-2000 (John et al. 2004) showed 75 meningitis cases of which at least 27 were bacterial meningitis. Assuming that one third of this is due to Hib, for a 26 milli on birth cohort, the estimated Hib meningitis is 52000 per year. Using the validated Hib Rapid Assessment Tool estimates, that allows pneumonia burden estimates based on meningitis data, the estimated Hib pneumonia cases would be 260000 per year (WHO 2001). John TJ, Rajappan K, Ar Read More... -
RTI document. GAVI wants to override NTAGI decision to study Pentavalent vaccine in Kerala and Tamil Nadu
RTIGoIRTI document GAVI will withdraw Rs 530 crores alloted to India if India does not extend Pentavalent to 6 more states (against NTAGI recommendation of trial in 2 states. Government will have to spend Rs 1370 crores to get GAVI 530 crores -
Minutes of the Expert group meetin gs on Hepatitis B and Hib vaccines
http://www.icmr.nic.in/minutes/Minutes%20Expert%20Group%20%20Hepatitis%20B%20and%20Hib%20vaccines.pdfA study on HBV disease profile based on liv er biopsy of consecutive patients who were HbsAg positive presenting to AIIMS from Jan. 2008 to June 2009,showed that 80% are silent infections. 44% of the patients were asymptomatic healthy carriers, 13% were immunotolerant, 28% were HBeAg positive chronic hepatitis 7 and 15% were HBeAg negative chronic hepatitis (Data from AIIMS:personal communication Dr.S.K.Acharya).  Based on the natural course of the HBV infecti Read More... -
National Vaccine Policy . First Draft and Criticism
-
Pentavalent vaccine: Doing more harm than good?
Express Pharma http://pharma.financialexpress.com/sections/res/1971-pentavalent-vaccine-doing-more-harm-than-goodJacob PuliyelJacob Puliyel, Head of Pediatrics, St Stephens Hospital Delhi, questions whether the time has come to stop using Pentavalent vaccine for immunisation Immunisation with the new Pentavalent vaccine resulted in the recent death of two babies in Kerala. This combination vaccine was to replace the trivalent DPT (against diphtheria, whooping cough, tetanus vaccine) and additionally protects against Haemophilus influenzae type b and Hepatitis B. The post mortem certificate in both babies stated: “ Read More... -
Minutes of NTAGI meeting 26th August 2010 Altered version
NTAGI GoI -
Minutes of NTAGI 26th August 2010 Original version
NTAGI GoI -
India polio data 2000 to 2012
http://bit.ly/npsi_dataPuliyel J -
Public Interest Petition (PIL) Vaccine case 10th submission with new prayer 18/04/13
Prashant Bhushan on behalf of the petitionersIN THE HIGH COURT OF DELHI AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) C.M. No. OF 2013 IN WRIT PETITION (CIVIL) No. 13698 OF 2009 PUBLIC INTEREST LITIGATION IN THE MATTER OF: DR. K. B. SAXENA & ORS. �PETITIONERS VERSUS UNION OF INDIA & ORS. �RESPONDENTS APPLICATION FOR AMENDMENT OF PRAYERS OF THE WRIT PETITION UNDER SECTION 151 CPC To, The Hon�ble Chief Justice of Delhi And His Hon�ble Compani Read More... BBC World News - Discussion on Polio on Impact
http://www.youtube.com/watch?v=YE4IIGTzWdYMishal Husain, Hamid Jafari, Shahnaz Wazir AliPublished on May 8, 2013 Mishal Husain was joined on the Impact programme by Dr Jacob Puliyel, head of Pediatrics at St Stephens Hospital from Delhi, and in the studio by the World Health Organisation's Polio Director Hamid Jafari, and Shahnaz Wazir Ali, the Government of Pakistan's special adviser on polio.-
Making a case for universal Hib immunization in India: over interpreting the data
Indian J Med Res 137, April 2013, pp 639-641,Jacob PuliyelMaking a case for universal Hib immunization in India; over interpreting the data This issue of the IJMR features the results of a prospective sentinel surveillance for Hemophilus influenza B (Hib) meningitis. (1) The National Technical Advisory Group on Immunization (NTAGI) in its meeting of 26 August 2010 recommended that Pentavalent vaccine containing Hib be introduced in the states of Kerala and Tamil Nadu. (2) Since there was concern about its adverse effects (AEFI), this was to be monit Read More... -
Draft minutes of causality assessment meeting held at LHMC on 15-Feb,13 presented to AEFI Meeting April 22, 2013
-
NTAGI commttee on AEFI Pentavalent vaccine Minutes of meeting of 22.04.13 Offives of Prof S K Panda AIIMS
NTAGI Subcommittee -
Personal notes of Meeting 22.04.2013 in the Room of Dr. S K Panda. AIIMS
-
PubMed Commons comment to Williams et al on AEFI
http://www.ncbi.nlm.nih.gov/pubmed/23452584#cm23452584_3553Jacob PuliyelWilliams and colleagues have described assessment of AEFI employing the algorithm described by Halsey < PMID: 22507656>. I have posted two very detailed comments to an article by Tozzi Tozzi AE, 2013 which discusses the same subject of the revised WHO Classification of AEFI. I will not repeat the points I have made there but it may be viewed here. As this is a matter of patient safety I think it is important that the experts who understand the new scheme must explain why the revision Read More... -
Misplaced hoopla over Indian anti-diarrhea vaccine
IANS republished in various including http://en-maktoob.news.yahoo.com/misplaced-hoopla-over-indian-anti-diarrhea-vaccine-062414862.html and Indian Express http://newindianexpress.com/nation/Misplaced-hoopla-over-Indian-anti-diarrhea-vaccine/2013/06/25/article1652305.eceJacob PuliyelMisplaced hoopla over Indian anti-diarrhea vaccine IANS By Jacob Puliyel | IANS Newspapers and television channels in India and abroad were abuzz recently with reports that an Indian rotavirus (anti-diarrhea) vaccine had been developed and tested. We were told that the vaccine, called Rotavac, is to be sold at $1/dose (Rs.60) compared to the existing brands costing $10-$50/dose. The announcement was made at a symposium on rotavirus vaccine in New Delhi. Many doctors and scientists were h Read More... -
AEFI and the pentavalent vaccine: looking for a composite picture
Indian Journal of Medical Ethics Vol X No 3 July-September 2013 Pages 142-6. http://ijme.in/pdfs/213ed142.pdfJacob PuliyelEDITORIAL AEFI and the pentavalent vaccine: looking for a composite picture JACOB PULIYEL1 PDF Georg Christoph Lichtenberg's reference to "a knife without a blade, for which the handle is missing" has been illustrated recently by Broomberg and Oliver Chanarin (1). In his work, Jokes and their relation to the cognitive unconscious, Freud suggested that the "knife without a blade which has no handle" is as absurd or funny as a "frame without a picture" Read More... -
Vaccine utilization rather than disease mitigation is the target. Response to Should Europe have a universal hepatitis B vaccination programme?
BMJ 2013;347:f5187 doi: http://www.bmj.com/content/347/bmj.f5187?ijkey=c2KsVOga5BVB6M5&keytype=refJacob PuliyelVaccine utilization rather than disease mitigation is the target 8 August 2013 Including vaccines in the routine immunization programmes of countries has become a kind of fetish with the WHO – disconnected from its purpose of reducing disease. Thus the WHO has recommended Hepatitis B vaccine for all countries. It has recommended that at least 3 doses of the vaccine must be used in each person regardless of whether it is given at birth, in infancy or during adolescence. (1) Vaccinating adol Read More... ICMR funded project Analysis of food logs from 6 States RHN/adhoc 59/2011-2012 dt 16/3/12 Principal Investigator Jacob Puliyeld Nutrient Intake in 6 States
Report to ICMR Public Report on Health: Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 StatesC Sathyamala, N J Kurian, Anuradha De, K B Saxena, RituPriya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, SnehKhalsa, Ashish Puliyel, Jacob Puliyel.Public Report on Health: Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States C Sathyamala, N J Kurian, Anuradha De, K B Saxena, RituPriya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, SnehKhalsa, AshishPuliyel, Jacob Puliyel. On behalf of the Public report on Health Address for correspondence Jacob Puliyel Department of Pediatrics St Stephens Hospital Delhi 110054 puliyel@gmail Read More...-
ICMR Funded Multi-center Project - A Study Of Hepatitis B Vaccine Effectiveness depending on vaccination schedule.
VIR/13/2011/ECD-1 dated 20.9.2013St Stephens Hospital to Administer multi-center study. Rs 44,99,760. 00 grant sanctioned from ICMR. Principal Investigator Jacob Puliyel. Collaborators Arvind Lal, Neelum Tripathi, Nimmi Kausal, Kishore Agarwal, Pramod Upadhyaya. Participating Centers Lals Laboratories, National Institute of Immunology, Sardanmal Kaandaka Memorial Hospital Jaipur, St Stephens Hospital Delhi. -
Immunisation: Challenges of Ensuring Public Health: Assessing the Past, Charting the Future
Yojana Feb 2014 http://yojana.gov.in/Jacob PuliyelNational Technical Advisory Group on Immunization (NTAGI): Challenges of moving past the paternalistic paradigm to allow greater public participation in vaccine decisions The practice of medicine traditionally, used to be a paternalistic affair – with the doctor telling the patient what to do and the patient being expected to follow orders. The wishes, feelings, beliefs and values of the patient did not merit much consideration. The arrogant assumption was that the doctor knows best. Doct Read More... -
Comment: Impact and cost-effectiveness of Haemophilus influenzae type b conjugate vaccination in India. Clark AD.J Pediatr. 2013
http://www.ncbi.nlm.nih.gov/pubmed/23773596#cm23773596_2581Pinky Bahl MD, Supriya Rastogi DCH, Jacob Puliyel MDImpact and cost-effectiveness of Haemophilus influenzae type b conjugate vaccination in India. Clark AD.J Pediatr. 2013. PMID:23773596 In: PubMed Commons [Internet]. Bethesda (MD): National Library of Medicine; 2014 Feb 4. Available from: http://www.ncbi.nlm.nih.gov/myncbi/puliyel/comments/ Comment Jacob Puliyel This comment has been written after correspondence through the journal with the authors. The WHO considers programmes cost-effective, if they cost less than 3 X GDP per capita Read More... -
2nd Comment: Assessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use. Tozzi AE.Vaccine. 2013.
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2881Jacob PuliyelJacob Puliyel2014 Feb 20 Tozzi and colleagues state that their article describes the new tool for causality assessment of AEFI as set out in the User Manual for the Revised WHO Classification 1) However this manual it seems has been developed without adequate care and without thinking through the consequences of the changes. a) One pointer to this is how the manual cites an example of vaccines being wrongly blamed for events unrelated to its administration (Page 13). It says that vaccines w Read More... -
Comment: Assessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use. Tozzi AE.Vaccine. 2013.
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2587Jacob PuliyelAssessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use. Tozzi AE.Vaccine. 2013.Comment In: PubMed Commons [Internet]. Bethesda (MD): National Library of Medicine; 2014 Feb 4. Available from: http://www.ncbi.nlm.nih.gov/myncbi/puliyel/comments/ Jacob Puliyel DEATHS IN DEVELOPING COUNTRIES WILL COUNT FOR LESS Tozzi et al describe causality assessment for AEFI using criteria from the CIOMS/WHO working group on pharmacovigilence . Read More... -
IT IS EXPEDIENT BUT IS IT PRUDENT TO LABEL ADVERSE EVENTS FOLLOWING IMMUNIZATION AS 'NOT AN EVENT OF [AEFI]'?
http://www.ncbi.nlm.nih.gov/pubmed/19061929#cm19061929_3193Jacob PuliyelIT IS EXPEDIENT BUT IS IT PRUDENT TO LABEL ADVERSE EVENTS FOLLOWING IMMUNIZATION AS 'NOT AN EVENT OF [AEFI]'? The old scheme of monitoring signals for vaccine safety (adverse events following immunization � AEFI monitoring), of the Advisory Committee on Causality Assessment Collet JP, 2000 has been overtaken by the Revised WHO Classification of AEFI. The changes have been described in 4 PubMed articles Tozzi AE, 2013, Bonhoeffer J, 2009, Halsey NA, 2012, Williams SE, 2013. I Read More... -
The full analysis including Tables and Graph: 6500 AEFI DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE
Jacob Puliyel6500 PENTAVALENT-VACCINE AEFI-DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE I thank Dr Malik for endorsing my opinion that the AEFI guidelines need to be revised. Unfortunately neither Tozzi and colleagues, nor [Bonhoeffer et al](http://www.ncbi.nlm.nih.gov/pubmed/19061929#cm19061929_3193) <PMID: 19061929> have responded and we do not know if the authors agree with us. Dr Malik’s comment points out that India lacks a strong system of AEFI surveillance and investigation. This is Read More... -
MINISCULE RISK REDUCTION MAKES $1 ROTAVIRUS VACCINE (116E) UNECONOMICAL IN INDIA
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_3808Saurabh Kumar, Jacob PuliyelJacob Puliyel2014 Apr 04 3:26 p.m. edited MINISCULE RISK REDUCTION MAKES $1 ROTAVIRUS VACCINE (116E) UNECONOMICAL IN INDIA The authors must be congratulated for this study and the candid reporting of the absolute risk reduction (ARR) and numbers needed to treat (NNT). LOW DISEASE BURDEN Although rotavirus vaccine efficacy is lower in developing countries, it is advocated for poor countries because of the higher disease burden. Severe rotavirus gastroenteritis (SRVGE) was more common Read More... -
50% More Intussusception Among Vaccinated: Full Trial Data Is Awaited
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_3970J Puliyel50% More Intussusception Among Vaccinated: Full Trial Data Is Awaited According to the Clinical Trials Registry this study, started in March 2011 was estimated to be complete in April 2014. The data published in Lancet on March 12, 2014 refers only to the first half of the study (efficacy and safety of ORV 116E assessed in the first year of life). Data on efficacy and safety up to 2 years (from 14 days following the 3rd dose till the age of 2 years (24 months) + up to 14 days.) is still aw Read More... -
PubMed Commons Response 3 to Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian infants: a randomised, double-blind, placebo-controlled trial.
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_4036Jacob PuliyelThe authors have not responded to my invitation to participate in this discussion on the PubMed Commons as yet. One of the authors Professor Gagandeep Kang has however sent a response to another discussion group discussing the comment. I will quote her concluding statement below. “While I agree with Dr. Puliyel that AEFI surveillance is essential (and more critically, providing increased access to care in any medical emergency), I would question the ethics of waiting for a rate of a Read More... -
PubMed Commons Comment: Post-marketing surveillance cannot properly estimate risks. Comment on Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program.Carlin JB. et al
http://www.ncbi.nlm.nih.gov/pubmed/23964090#cm23964090_4600Jacob PuliyelPost-marketing surveillance cannot properly estimate risks The authors must be congratulated for conducting a study whose scope was so vast. However it must be recognized that RCTs are the best method to look for risks and benefits. Post-marketing surveillance is relied on to detect rare adverse events. It has severe limitations in quantifying the magnitude of risks. The present study highlights the problem well. 1 The authors estimate the risk of intussusceptions (IS) in two window period Read More... -
Public Report on Health: Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States
Journal of Clinical and Diagnostic Research [serial online] 2014 May [cited: 2014 May 24 ]; 8:PC06-PC12. http://www.jcdr.in/pdf_download.asp?issn=0973-709x&year=2014&month=May&volume=8&issue=5&page=PC06-PC12&id=4389C Sathyamala, NJ Kurian, Anuradha De, KB Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, Sneh Khalsa, Ashish Puliyel, Jacob PuliyelPublic Report on Health: Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States C Sathyamala, N J Kurian, Anuradha De, K B Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, Sneh Khalsa, AshishPuliyel, Jacob Puliyel. On behalf of the Public report on Health Address for correspondence Jacob Puliyel Department of Pediatrics St Stephens Hospital Delhi 110054 puliyel@gmail Read More... -
Association of birth of girls with postnatal depression and exclusive breastfeeding: an observational study
BMJ Open 2014;4:e003545 doi:10.1136/bmjopen-2013-003545Akanksha Jain. Prashant Tyagi, Prabjeet Kaur, J Puliyel, V SreenivasAbstract Objectives and hypothesis To examine the influence of gender of the baby on exclusive breastfeeding and incidence of postnatal depression (PND). We hypothesise that in a society with a male gender bias there may be more PND and less exclusive breastfeeding of the girl child. Design Prospective study. Setting The study was conducted in an urban, tertiary hospital in Delhi. Participants Mothers delivering normally with their babies roomed-in.1537 eligible women participated in Read More... -
6500 PENTAVALENT-VACCINE AEFI-DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_3394Jacob Puliyel6500 PENTAVALENT-VACCINE AEFI-DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE I thank Dr Malik for endorsing the opinion that the AEFI guidelines need to be revised. Unfortunately neither Tozzi and colleagues, nor Bonhoeffer et al (Bonhoeffer J, 2009) have responded and we do not know if the authors agree with us. Dr Malik�s comment points out that India lacks a strong system of AEFI surveillance and investigation. This is undisputable. The fact of this poor surveillance in some States is Read More... -
DEATHS IN DEVELOPING COUNTRIES WILL COUNT FOR LESS Comment on Assessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use. Tozzi AE.Vaccine. 2013
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2587Jacob PuliyelJacob Puliyel2014 Feb 04 1:10 p.m. DEATHS IN DEVELOPING COUNTRIES WILL COUNT FOR LESS Tozzi et al describe causality assessment for AEFI using criteria from the CIOMS/WHO working group on pharmacovigilence . AEFI is any untoward medical occurrence following immunization. A causal relationship is not implied. The Brighton collaboration classified reactions as very likely/certain; probable; possible; unlikely; unrelated; unclassifiable, based on temporal criteria and evidence of alternate etiol Read More... -
116E Rotavirus Vaccine Efficacy Against Death is 10% of Projected Figures. Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development. Bhan MK.Lancet. 2014
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5899.Puliyel JAbstract Send to: See comment in PubMed Commons below Lancet. 2014 Jun 21;383(9935):2180-3. doi: 10.1016/S0140-6736(14)60191-4. Epub 2014 Mar 12. Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development. Bhan MK1, Glass RI2, Ella KM3, Bhandari N4, Boslego J5, Greenberg HB6, Mohan K3, Curlin G7, Rao TS8. Author information PMID: 24629993 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, Substances Read More... -
Sir Andrew Witty CEO GlaxoSmithKline responds through Norman Begg to Infanrix controversy related to PSUR 16
Response to http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656Dr Normn BeggGlaxoSmithKline Vaccines SA Avenue Fleming 20 B-1300 Wevre Belgium Tel +32 (0)10853700 Via email: puliyel@gmail.com Jacob Puliyel, MD MRCP M Phil Head of Pediatrics St. Stephens Hospital Dehli, India Wavre, 14 January 2015 Dear Dr. Puliyel, Your email dated 12 January 2015 addressed to Sir Andrew Witty in which you make reference to GlaxoSmithKline’s Infanrix-hexa Periodic Safety Update Report (PSUR) for the period 23 October 2009 to 22 October 2011 Read More... -
PubMed Commons Postings 1-22 on Infanrix Hexa, TOKEN study Rotavirus 116E and CIOMS/ WHO new classification of AEFI altering Brighton Classification
http://www.ncbi.nlm.nih.gov/myncbi/jacob.puliyel.1/comments/Jacob Puliyelhttp://www.ncbi.nlm.nih.gov/myncbi/jacob.puliyel.1/comments/ PubMed US National Library of Medicine National Institutes of Health Search database Search term Jacob Puliyel << First< Prev Page of 2 Next >Last >> Comments 1 to 20 of 22 • Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy. Baldo V.Hum Vaccin Immunother. Read More... -
Trends in nonpolio acute flaccid paralysis incidence in India 2000 to 2013
Pediatrics. 2015 Feb;135 Suppl 1:S16-7. doi: 10.1542/peds.2014-3330DD. PMID: 26005734Vashisht N, Puliyel J, Sreenivas V.Trends in Non-Polio Acute Flaccid Paralysis incidence in India 2000-2013 N. Vashisht J.M. Puliyel* V. Sreenivas** Department of Pediatrics, Jaypee Hospital, Sector-128, Noida,GautamBuddh Nagar-201304, UP *Department of Pediatrics, St. Stephen's Hospital, Tis Hazari, Delhi 110054, India **Department of Biostatistics, All India Institute of Medical Sciences, New Delhi – 110029, India Short title: Non-Polio Acute Flaccid Paralysis Key words: Acute flaccid paralysis, survei Read More... -
PubMed Commons on Tozzi article on AEFI Response to Dr A Malik
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_3490Jacob PuliyelJacob Puliyel2014 Mar 18 12:28 p.m. (just added) Dr Malik, as part of the India Government Ministry of Health, has information on the AEFIs with Pentavalent vaccine and their investigation. I mention individual instances because Dr Malik is familiar with them and it best illustrates the harm done by the new system of AEFI classification. Of the 54 deaths reported to the Government of India some have been investigated and the AEFI reports are available here The deaths as described below Read More... -
Why more vaccines won't translate to better health
http://www.moneylife.in/article/why-more-vaccines-wont-translate-to-better-health/38107.htmlJacob Puliyel, B M HegdeMoneylife » Life » Wellness » Why more vaccines won't translate to better health Why more vaccines won't translate to better health Dorit Reiss Dorit Reiss 2 comments + COMMENT Dr Jacob Puliyal & Professor BM Hegde | 16/07/2014 12:24 PM | If vaccination was such a good method of disease prevention we should have been able to eradicate many contagious disease, but alas, records show that except small pox we have not been able to e Read More... -
INTRA GASTRIC PRESSURES IN NEONATES RECEIVING BUBBLE CPAP
J Matern Fetal Neonatal Med, 2014; 27(S1): 436-7P. Tyagi, N. Gupta, A. Jain, P. Upadhyay, & J. PuliyelBrief Introduction: Although bubble CPAP is seen to be superior to continuous steady pressure CPAP, it is reported that its pressure delivery system can be highly variable and unpredictable. CPAP has been associated with gastrointestinal adverse effects – although rarely. The CPAP belly syndrome is one such adverse effect characterised by gaseous bowel-distension in infants treated with nasal CPAP. The pressures transmitted from oropharynx to stomach during BCPAP are not known. Int Read More... -
Lactate clearance as a marker of mortality in pediatric intensive care unit.
Indian Pediatr. 2014 Jul 8;51(7):565-7. http://www.indianpediatrics.net/july2014/565.pdfMunde A, Kumar N, Beri RS, Puliyel JM.Objectives : To correlate lactate clearance with Pediatric Intensive Care Unit (PICU) mortality. Methods : 45 (mean age 40.15 mo, 60% males) consecutive admissions in the PICU were enrolled between May 2012 to June 2013. Lactate clearance (Lactate level at admission – level 6 hr later x 100 / lactate level at admission) in first 6 hours of hospitalization was correlated to in-hospital mortality and PRISM score. Results : Twelve out of 45 patients died. 90% died among those with Read More... -
Doctors question efficacy of rotavirus vaccine
The Hindu Delhi Page 4Dr Maturam Santosham from Johns Hopkins School of Public Health USA, and co-chairman of the ROTA Council has written in The Hindu on the need to turn the corner on child health (31/7/14). However his prescription appears seriously flawed. He writes impassionedly in favor of introducing the Rotavirus vaccine saying that the average cost of hospitalization for each episode of rotavirus diarrhea is Rs 3000. However the paper published in the Lancet states that the vaccine that has now been license Read More... -
Comment on: Intussusception in southern India: Comparison of retrospective analysis and active surveillance.
http://www.ncbi.nlm.nih.gov/pubmed/25091689#cm25091689_5704J PuliyelIntussusception in southern India: Comparison of retrospective analysis and active surveillance. Jehangir S.Vaccine. 2014.1 comment Jacob Puliyel2014 Aug 12 08:51 a.m. (4 hours ago)edited I congratulate the authors of this analysis. However their analysis begs more questions than it answers. They found that there were 581 cases of ultrasound diagnosed intussusception per 100,000 child years, during the Rotavirus trial, which works out to be 1 intussusception in every 172 children, ea Read More... -
Comment on: Efficacy of a monovalent human-bovine (116E) rotavirus vaccine in Indian children in the second year of life. Bhandari N. Vaccine. 2014
http://www.ncbi.nlm.nih.gov/pubmed/25091663#cm25091663_5692Puliyel JJacob Puliyel2014 Aug 12 01:11 a.m. (12 hours ago) I read with interest this paper that describes efficacy and safety of the 116E rotavirus vaccine in the 2nd year of the trial. The results for the first year were published earlier in June 2014 Bhandari N, 2014. The authors need to be congratulated for this study. However some of the data appears incongruous. According to the clinical trial registry http://clinicaltrials.gov/show/NCT01305109 one of the secondary outcome measures was to be &qu Read More... -
Licensing the vaccine for general use (in remote areas of India), seems impossible to justify. Comment on: Active surveillance for intussusception in a phase III efficacy trial of an oral monovalent rotavirus vaccine in India. John J. Vaccine 2014
http://www.ncbi.nlm.nih.gov/pubmed/25091662#cm25091662_5770Puliyel JLicensing the vaccine for general use (in remote areas of India), seems impossible to justify I commend Dr John and colleagues for this report on the trial with the 116E Indian rotavirus vaccine. However the authors limit their discussion to comparisons with the trials of Rotarix and Rotateq which recruited some 60,000 patients each. It will be more useful to compare the 116E trial safety results with the RotaSheild vaccine trials http://www.path.org/vaccineresources/files/RotaShield_Fact_She Read More... -
Team science must not be allowed to influence objectivity: Projections of deaths exaggerated 5 times. Comment on: Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development. Bhan MK
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5773J Puliyel**Team science must not be allowed to influence objectivity** **Projections of deaths exaggerated 5 times** The authors must be congratulated for describing the team effort involved in the development of the new 116E rotavirus vaccine. In this process the Government of India through its funding of the Department of Science and Technology, the Bill and Melinda Gates foundation and PATH; all became partners who had a stake in getting this vaccine licensed and commercialized. Objectivity can Read More... -
116E Rotavirus Vaccine Efficacy Against Death is 10% of Projected Figures. Comment on: Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development.
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5899J PuliyelThe time lines described by Professor Bhan <PMID: 24629993> suggest that the private manufacturer to set up the plant for manufacture of this vaccine was funded by PATH, B&MG and the Government of India (DBT) in 2000, where as the Phase 3 trial only started in 2008. It is clear that regardless of efficacy in the phase 3 trial (or any objections by NTAGI members,) the vaccine had to be rolled out, if there was to be any returns on the investment. I am less concerned about this waste Read More... -
Government's UIP: Pressure from international organizations to include vaccines for other diseases
http://economictimes.indiatimes.com/opinion/comments-analysis/governments-uip-pressure-from-international-organizations-to-include-vaccines-for-other-diseases/articleshow/41280844.cms Also see http://m.economictimes.com/industry/healthcare/biotech/healthcare/Controversial-vaccine-studies-Why-is-Bill-Melinda-Gates-Foundation-under-fire-from-critics-in-India/articleshow/4128Jacob Puliyel -
International Student of the Year University of Edinburgh Nirupa Puliyel’s winning essay
http://www.ed.ac.uk/news/all-news/essayNirupa PuliyelNirupa Puliyel’s winning essay When watching Braveheart last night with a group of international student friends we were surprised to find ourselves cheering when scenes featuring Edinburgh came on. My French friend summarised it perfectly at the end of the movie. In what was a poor imitation of Mel Gibson’s accent (itself a poor imitation) she exclaimed: “Och aye! Makes you proud to be Scottish!†Edinburgh is truly a city that absorbs you into its arms, regard Read More... -
NEW MODELS FOR PUBLIC- PRIVATE PARTNERSHIPS IN HEALTH PROMOTION
The Road to Universal Health Coverage. 12th India Infrastructure Report. 2013-14. Chapter 16 Page 203 to 212 IDFC FoundationOrient BlackSwan New Delhi ISBN 978 81 250 5610 2 http://www.idfc.com/pdf/report/2013-14/Chapter-16.pdfJacob PuliyelThe last two decades have been the era of public-private partnerships (PPPs). The Saskatchewan Institute of Public Policy defines PPPs as co-operative ventures between public and private sectors, built on the expertise of each partner which meets clearly defined public needs through appropriate allocation of resources, risks and rewards (Allan 2001). A particularly important element is the emphasis upon risk-sharing, joint investment of resources, and sharing of authority. These factors Read More... -
Letter to PMO Concerns about deaths of young children following Pentavalent Vaccine
NilProfessor BM Hegde MD, PhD (Hon. Causa), FRCP (London), FRCP (Edinburgh), FRCP (Glasgow), FRCPI (Dublin), FACC, FAMS. Dr Vikas Bajpai Professor Amitav Banerjee Dr J P Dadhich MD Dr Arun Gupta MD FIAP Professor S K Mittal Professor Ritu Priya MBBS, Ph.D. Dr Jacob Puliyel MD MRCP M Phil Professor S Srinivasan MD Professor KP KushwahaDate: 25th November 2014 To The Prime Minister Prime Minister’s Office South Block Raisina Hill New Delhi-110011 Sir Subject: Concerns about deaths of young children following Pentavalent Vaccine Every few days one more child dies after receiving the Pentavalent vaccine. The Deccan Herald of 22 August 2014 reported 2 more deaths from Haryana with the Pentavalent vaccine (http://www.deccanherald.com/content/427027/2-kids-die-vaccination-haryana.html). Last week i Read More... -
INTRA GASTRIC PRESSURES IN NEONATES RECEIVING BUBBLE CPAP
The Indian Journal of Pediatrics February 2015, Volume 82, Issue 2, pp 131-135. Ind J Pediatr. 2014 Sep 4. [Epub ahead of print] PMID: 25186564Prashant Tyagi, Neeraj Gupta, Akanksha Jain, Jacob Puliyel, Pramod UpadhyayINTRA GASTRIC PRESSURES IN NEONATES RECEIVING BUBBLE CPAP Prashant Tyagi1, Neeraj Gupta1, Akanksha Jain1,Jacob Puliyel1, Pramod Upadhyay 2 (1) Department of Paediatrics and Neonatology, St. Stephen’s Hospital, New Delhi. (2) National Institute of Immunology, New Delhi. Address for communication Prashant Tyagi C/O Jacob Puliyel Deptt. of Paediatrics St Stephens Hospital Tis Hazari Delhi 11054 Email puliyel@gmail.com ABSTRACT Objectives of th Read More... -
Controversies surrounding mercury in vaccines: autism denial as impediment to universal immunisation
Indian Journal of Medical Ethics Vol XI No 4 October-December 2014. http://www.issuesinmedicalethics.org/index.php/ijme/article/view/2132/4598RITIKA CHHAWCHHARIA , JACOB M, PULIYELTITLE: Controversies surrounding mercury in vaccines: autism denial as impediment to universal immunisation AUTHORS: RITIKA CHHAWCHHARIA1, JACOB M PULIYEL2 AFFILIATIONS: 1Senior Registrar, Department of Paediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054 INDIA 2Consultant Paediatrician and Head of Department of Paediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054 INDIA Author for correspondence: Jacob M Puliyel e-mail: puliyel@gmail.com In 2004, the US Center for Disease Read More... -
Utility of Hepatitis B Vaccination in India
Indian Pediatrics 2014;51:870-2 http://www.indianpediatrics.net/nov2014/870.pdfRAJEEV KUMAR AND JACOB PULIYELUtility of Hepatitis B Vaccination in India Global health interventions are being scrutinized more closely than previously. According to an article in Science, the Center for Global Development in Washington has begun looking for hard evidence in real-life field conditions, whether a large-scale interventions have directly led to lower numbers of cases or deaths and whether the improvements are sufficient to justify the costs.(1) This issue of Indian Pediatrics has a limited evaluation of t Read More... -
Trends in Non-Polio Acute Flaccid Paralysis incidence in India 2000-2013
Excellence in Pediatrics (EiP) Dubai 4 to 6 December 2014N. Vashisht, J.M. Puliyel, V. SreenivasTrends in Non-Polio Acute Flaccid Paralysis incidence in India 2000-2013 N. Vashisht J.M. Puliyel* V. Sreenivas** Department of Pediatrics, Jaypee Hospital, Sector-128, Noida, Gautam Buddh Nagar-201304, UP *Department of Pediatrics, St. Stephen's Hospital, Tis Hazari, Delhi 110054, India **Department of Biostatistics, All India Institute of Medical Sciences, New Delhi – 110029, India Short title: Non-Polio Acute Flaccid Paralysis Key words: Acute flaccid paralysis, surv Read More... -
Trends In Non-polio Acute Flaccid Paralysis Incidence In India
http://webmedcentralplus.com/article_view/35Puliyel J, Vashisht N, Sreenivas V.Background Although the incidence of polio acute flaccid paralysis (AFP) is coming down in India, the non-polio AFP (NPAFP) rate has increased. Nationwide, the NPAFP rate is 13.7/100,000 where the expected rate is 1-2/100,000. We examined the correlates of NPAFP, to discern explanations for the increase. Methods National Polio Surveillance data 2000-2012 was used. Differences between states and changes over time were examined. Demographic factors and polio programme parameters were ass Read More... -
Decline in Immunization Coverage Across Well-performing Districts in India: An Urban Conundrum? Correspondence
Indian J Pediatr. 2015 May;82(5):490.Pinky Bahl, Jacob PuliyelThe Indian Journal of Pediatrics © Dr. K C Chaudhuri Foundation 2014 10.1007/s12098-014-1648-4 Correspondence Decline in Immunization Coverage Across Well-performing Districts in India: An Urban Conundrum? Correspondence Pinky Bahl1 and Jacob Puliyel1 (1) Department of Pediatrics, St. Stephens Hospital, Delhi, 110054, India Pinky Bahl Email: drpinkybahl@gmail.com Received: 28 October 2014Accepted: 1 December 2014Published online: 16 December 2014 Without Abstract To the Ed Read More... -
RTI of 27.8.13 Reply showing 16 (to 18) deaths in Kerala when 196038 infants were immunized with Pentavalent vaccine. See pages 1, 6 and 8.
-
Infanrix hexa vaccine and sudden unexpected deaths
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656Jacob PuliyelBaldo and colleagues quote 2 references to suggest that in Germany, a population-based evaluation demonstrated a possible safety signal for DTPa-HBV-IPV-Hib-SP but failed to show an imbalance between observed and expected SUD cases for DTPa-HBV-IPV/Hib <PMID:15602672> <PMID:16081190>. However this seems to be contradicted by the data that was submitted by the manufacturer to the regulatory authority and the analysis below. The GlaxoSmithKline Biological Clinical Safety and P Read More... -
Infanrix deaths previous Hexavac deaths and Asian Pentavalent Vaccine Deaths
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8719Jacob PuliyelApropos the earlier posting there are a couple of other facts that we must consider when looking at the incidence of sudden unexplained deaths immediately following vaccination with Infanrix. a) The safety assessment document has used the number of doses of vaccine distributed as the denominator. The report acknowledges that all the doses of the vaccine distributed, need not have been utilized. There can be another argument against using this denominator. As each child is given up to Read More... -
Response to Elisabetta Franco on Infanrix deaths
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8767Jacob PuliyelI thank the authors for their response to my comment. I was presuming that in the countries from where this data was gathered, sudden infant death or SIDS is considered 'unnatural death'. If that is so, these deaths will have been investigated by a competent forensic team and the immunization records will have been examined to check if the infant was up to date with its vaccinations or whether there was an element of neglect. Reporting bias (based on parents perception that vaccine Read More... -
MMR at 9 Months: Rushing in Where Others Fear to Tread?
Indian Pediatrics 2015;51:81-2 http://indianpediatrics.net/jan2015/80.pdfAnoop Sharma, Jacob PuliyelI NDIAN P We read with interest the IAP Committee on Immunization (IAPCOI) recommendation on MMR vaccine at 9 months of age [1]. In this context, we studied the 2014 immunization practices across 121 countries, including 4 countries in Africa, 34 in the Americas, 13 in the Eastern Mediterranean region, 51 in Europe, 15 Western Pacific countries and 4 South East Asian countries. In none of these countries is MMR given at 9 months, except Mongolia and Thailand. Germany uses it between 11 Read More... -
Response to Tamás Ferenci on Infantrix deaths
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656Jacob PuliyelI thank Ferenci and Miller for their responses. I will address the three points made by Dr Ferenci 1) The data I have quoted (from Table 36) was made available by the manufacturers GSK, to defend the safety record of Infanrix Hexa to the regulatory authority (- the EMA). The data suggests a cluster on and following the day of vaccination. If the reporting is so bad the clusters aren't real, then the data can't/shouldn't be used to defend its safety. If the reporting is good, th Read More... -
Infanrix deaths, precautionary principles, and how TOKEN study shows pentavalent vaccine causes deaths
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8998Jacob PuliyelJacob Puliyel2015 Feb 06 1:11 p.m. (4 days ago) Dear Dr Ferenci The EMA I understand is obliged by European Union law to engage the precautionary principle. Until the full scientific evidence is available, where there is evidence of risk, it must take precautionary measures. The comments here indicate the evidence is of more than a risk, but of the harm itself. You say Dr. Franco cited studies that Infanrix Hexa is safe. Which ones and where? I can see Dr Franco has cited WHO and CDC statemen Read More... -
Intussusception risk with 116E rotavirus vaccine in Vellore, South India
Vaccine. 2015 Mar 20. pii: S0264-410X(15)00293-5. doi: 10.1016/j.vaccine.2015.03.007Jalaj Bajaj, Jacob M. PuliyelLetter to the Editor Intussusception risk with 116E rotavirus vaccine in Vellore, South India Jalaj Bajaj Jacob M. Puliyel puliyel@gmail.com St Stephens Hospital Delhi. Stephens Hospital, Delhi, India âŽCorresponding author. Tel.: +91 9868035091 We congratulate John and colleagues for their surveillance of intussusception during the 116E rotavirus vaccine trial [1]. They point out that it is critical to be vigilant to the risk of intussusception “to determine if there are safety Read More... -
National Polio Surveillance India data 2000 -2013 NPSP Polio surveillance data on Acute Flaccid Paralysis (AFP) and non-polio AFP and Demographic data
Data used for Trends in Non-Polio AFP published in abstract in Pediatrics. 2015 Feb;135 Suppl 1:S16-7. doi: 10.1542/peds.2014-3330DD. PMID: 25646230 -
116 E Rotavirus Vellore Study: Request for Vaccine Safety Data. Response to Indian rotavirus vaccine concern over intussusception is unfounded, say researchers
http://www.bmj.com/content/350/bmj.h2867/rapid-responsesJacob M. PuliyelBMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h2867 (Published 27 May 2015) Cite this as: BMJ 2015;350:h2867 Article Related content Article metrics Rapid responses Response 116 E Rotavirus Vellore Study: Request for Vaccine Safety Data The report contains a number of misleading assertions and a fundamental misunderstanding of statistics. These need to be corrected. The Rotavirus 116E trial was registered with the Clinical Trials Registry ClinicalTrials.gov Read More... -
PIL High Court Delhi for Vellore Rotavirus data
W.P.(C) 1524/2015Prashant Bhushan and Neha Bharadwaj for Jacob PuliyelIN THE HIGH COURT OF DELHI, AT NEW DELHI (CIVIL ORIGINAL JURISDICTION) Writ Petition (Civil) No. W.P.(C) 1524/ of 2015 A WRIT PETITION IN PUBLIC INTEREST UNDER ARTICLE 226 OF THE CONSTITUTION OF INDIA SEEKING A WRIT DIRECTING THE RESPONDENTS TO PROVIDE COMPLETE DATA OF THE RESULTS OF A MULTICENTRE CLINICAL TRIAL OF ROTAVIRUS VACCINE DONE ON INFANTS. MEMO OF PARTIES In the matter of Public Interest Litigation: JACOB PULIYEL, MD, MRCP MPhil ST STEPHENS HOSPITAL DELHI 110054 ..†Read More... -
Pediatric Protocol WORD
-
Food Choices and Consequences for the Nutritional Status: Insights into Nutrition Transition in an Hospital Community
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140807Jitendra Piple, Ranjeet Gora, Pragati Purbiya, Ashish Puliyel, Parul Chugh, Pinky Bahl, Jacob PuliyelAbstract Introduction Although economic development is generally accompanied by improvements in the overall nutritional status of the country’s population the ‘nutritional transition’ often involves a shift to high energy diets and less exercise with negative consequences. This pilot study was done to examine if education of parents operates at the household level to influence dietary choices and the nutritional status of children in a small community of hospital workers. Read More... -
Verdict of Delhi High Court on RotaVirus Vellore data request as PIL
-
116E Rotavirus Vaccine May Have Less Impact in India Than Projected
Vaccine 33 (2015) 7142Jiteendra Kumar Piple, Jacob Puliyel116E Rotavirus Vaccine May Have Less Impact in India Than Projected According to an article published in Science, impact evaluation of global health programmes is becoming more stringent.(1) The Center for Global Development in Washington is demanding hard evidence in real-life field conditions, whether interventions have directly led to lower numbers of cases or deaths and whether the improvements are sufficient to justify the costs. In this milieu we find that some of the projections in Read More... -
New pentavalent rotavirus vaccine shows little efficacy against diarrhea
Vaccine. 2018 Jun 13. pii: S0264-410X(18)30772-2. doi: 10.1016/j.vaccine.2018.05.105. Available online 13 June 2018Lalit Kumar, Jacob PuliyelLetter to the Editor New pentavalent rotavirus vaccine shows little efficacy against diarrhea Lalit Kumar drlalitnarwat@gmail.com Jacob Puliyel Department of Pediatrics, St Stephens Hospital, Delhi 110054, India âŽCorresponding author. Keywords: Rotarix; Bovine human-reassortant pentavalent vaccine; Serum Institute of India Rotavirus vaccine is recommended as a means of reducing diarrheal morbidity and deaths in developing countries [1]. The original efficacy studies wi Read More... -
Polio data 2000-2017
Jacob Puliyel -
Correlation between Non-Polio Acute Flaccid Paralysis Rates with Pulse Polio Frequency in India
Int J Environ res Public Health 2018;15:1755 doi:10.3390/ijerph15081755 http://www.mdpi.com/1660-4601/15/8/1755/pdfRachana Dhiman , Sandeep C. Prakash, V. Sreenivas , Jacob PuliyelCorrelation between Non-Polio Acute Flaccid Paralysis Rates with Pulse Polio Frequency in India Rachana Dhiman 1, Sandeep C. Prakash 1, V. Sreenivas 2 and Jacob Puliyel 1,* 1 Department of Pediatrics, St Stephens Hospital, Delhi 110054, India; dhimanrachna48@gmail.com (R.D.); sandeepcpp25@gmail.com (S.C.P.) 2 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 10029, India; sreenivas_vishnu@yahoo.com * Correspondence: puliyel@gmail.com; Tel.: +91-986-803-5091 R Read More... -
Making Science Obsolete
https://www.bmj.com/content/363/bmj.k4152/rapid-responses https://www.bmj.com/content/363/bmj.k4152/rr-5Jacob PuliyelEditor's Choice A tale of two vaccines BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4152 (Published 04 October 2018) Cite this as: BMJ 2018;363:k4152 Article Related content Article metrics Rapid responses Response Making Science Obsolete Rajagopal's suggestion that it's "incumbent on journals to indicate on the web pages when an article has been rendered obsolete by new data" is novel and revolutionary. There is then no need for meta-analysis and complica Read More... -
Measuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire
Disabil Health J. 2018 Oct 16. pii: S1936-6574(18)30198-5. doi: 10.1016/j.dhjo.2018.10.003.Rahul Mopari Bhawna Garg Jacob Puliyel Sara VarugheseMeasuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire Rahul Mopari1 rahulm.doc@gmail.com Bhawna Garg2 CFA thestatisticalanalyst@gmail.com Jacob Puliyel1 puliyel@gmail.com Sara Varughese3 sara.varughese@cbm.org 1. St Stephens Hospital Delhi, 2. Independent Statistician. 135 Bhagirathi, Sector 9, Rohini, Delhi 3. CBM India Liaison Office, Bangalore. Address for communication Sara Varughese FRCS Country Director CBM India #140, â Read More... Measuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire
Disabil Health J. 2018 Oct 16. pii: S1936-6574(18)30198-5. doi: 10.1016/j.dhjo.2018.10.003.Rahul Mopari, Bhawna Garg, Jacob Puliyel, Sara VarugheseMeasuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire Rahul Mopari1 rahulm.doc@gmail.com Bhawna Garg2 CFA thestatisticalanalyst@gmail.com Jacob Puliyel1 puliyel@gmail.com Sara Varughese3 sara.varughese@cbm.org 1. St Stephens Hospital Delhi, 2. Independent Statistician. 135 Bhagirathi, Sector 9, Rohini, Delhi 3. CBM India Liaison Office, Bangalore. Address for communication Sara Varughese FRCS Country Director CBM India #140, â Read More...-
Reply to Comment on Dhiman, R. et al. Correlation of Non-Polio Acute Flaccid Paralysis Rate with Pulse Polio Frequency in India. Int. J. Environ. Res. Public Health 2018, 15, 1755
Int. J. Environ. Res. Public Health 2019, 16, 63; doi:10.3390/ijerph16010063 https://www.mdpi.com/1660-4601/16/1/63Rachana Dhiman, Sandeep C. Prakash, V. Sreenivas and Jacob Puliyel.Reply to Comment on Dhiman, R. et al. Correlation of Non-Polio Acute Flaccid Paralysis Rate with Pulse Polio Frequency in India. Int. J. Environ. Res. Public Health 2018, 15, 1755 Rachana Dhiman 1, Sandeep C. Prakash 1, V. Sreenivas 2 and Jacob Puliyel 1,* 1 Department of Pediatrics, St Stephens Hospital, Delhi 110054, India; dhimanrachna48@gmail.com (R.D.); sandeepcpp25@gmail.com (S.C.P.) 2 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 10029, India; sreenivas_ Read More... -
Revised World Health Organization (WHO)’s causality assessment of adverse events following immunization—a critique
https://f1000research.com/articles/7-243/v2Puliyel J, Naik P. -
Deaths Reported after Pentavalent Vaccine Compared with Death Reported after Diphtheria‑Tetanus‑Pertussis Vaccine: An Exploratory Analysis
Med J DY Patil Vidyapeeth 2018;11:99-105. http://www.mjdrdypv.org/downloadpdf.asp?issn=2589-8302;year=2018;volume=11;issue=2;spage=99;epage=105;aulast=Puliyel;type=2Jacob Puliyel, Jaspreet Kaur, Ashish Puliyel, Visnubhatla SreenivasDeaths Reported after Pentavalent Vaccine Compared with Death Reported after Diphtheria-Tetanus-Pertussis vaccine - An Exploratory Analysis Abstract Introduction Immunization is one of the most effective public health tools available to prevent death and disease. Serious adverse reactions following immunization (AEFI) are rare. However coinci-dental sudden-infant-death-syndrome (SIDS) deaths do occur temporally associated with vac-cination. In 2010 the Government of India (GoI) introduced Read More... -
‘Vaccine killing children instead of protecting them’
The Sunday Guardian http://www.sundayguardianlive.com/news/13137-vaccine-killing-children-instead-protecting-themJacob Puliyel.The Pentavalent vaccine (PV), which was introduced by India six years ago, doubled the deaths of children soon after vaccination, compared to the DPT (Diphtheria-Pertussis-Tetanus) vaccine, says a new study that calls for a “rigorous review of the deaths following vaccination with PVâ€. The study was conducted by Professor V. Sreenivas, Professor of Biostatistics, All India Institute of Medical Sciences. Government of India data was used throughout the study. It was published in th Read More... -
Autoimmune Haemolytic Anaemia: An Unusual Manifestation of Kawasaki Disease
Journal of Clinical and Diagnostic Research [serial online] 2018 April [cited: 2018 Apr 11 ]; 12:SD03-SD04. Available from http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=April&volume=12&issue=4&page=SD03-SD04&id=11370 DOI: 10.7860/JCDR/2018/32696.11370Aashish Gupta, Rahi Raza, Ayush Manchanda, Jacob PuliyelAutoimmune Haemolytic Anaemia: An Unusual Manifestation of Kawasaki Disease Aashish Gupta, Rahi Raza, Ayush Manchanda, Jacob Puliyel 1. Resident, Department of Paediatrics, St Stephens Hospital, Delhi, India. 2. Resident, Department of Paediatrics, St Stephens Hospital, Delhi, India. 3. Consultant, Department of Paediatrics, St Stephens Hospital, Delhi, India. 4. Head of Department, Department of Paediatrics, St Stephens Hospital, Delhi, India. Correspondence Address : Dr. Jacob Puliyel Read More... -
Parliament must be provided with correct study on Pentavalent.
https://www.sundayguardianlive.com/opinion/parliament-must-provided-correct-study-pentavalentJacob Puliyel.Home Opinion Parliament must be provided with correct study on Pentavalent Parliament must be provided with correct study on Pentavalent JACOB PULIYEL Updated : April 14, 2018, 5:58 PM jacob The deaths of healthy children taken for routine immunisation are not acceptable. On 18 March, The Sunday Guardian published a report suggesting that Pentavalent vaccine was killing children instead of protecting them. In response to a question on the subject, Union Minister for Health an Read More... -
Author's reply: Using CPAP for Bronchiolitis
Indian Pediatrics 2018;55:438-9Sandeep Lal Puliyel JM.Using CPAP for Bronchiolitis: Authors' Reply Sandeep Narayan Lal* and Jacob M Puliyel Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi, India. Email: sandeep.nlal@gmail.com The main point of criticism of our study [1] by all these readers is that we assessed only for benefits over the first hour of admission. This is a valid point. The reason for such protocol was the ethical issue. Theoretically, it was not logical to use CPAP (that increases Read More... -
Ethical questions surround vaccine to reduce fertility
https://www.sundayguardianlive.com/news/ethical-questions-surround-vaccine-reduce-fertilityJacob PuliyelThe prestigious journal Nature Medicine, in its February issue reported that the Indian Council of Medical Research (ICMR) is to do a clinical trial of a tetanus toxoid vaccine (TT) laced with a pregnancy hormone, human chorionic gonadotropin (hCG). It is to be studied on 120 women in India. This “vaccine†against pregnancy was developed by Dr G.P. Talwar in 1972. The idea is to produce antibodies to the pregnancy hormone, such that the women would not be able to carry a normal pr Read More... -
Clinical Trials: Secret Regime?
Indian Medical Parliamentarians' Forum Newsletter Volume 5 Number 3 Nov-Dec 2015 Page 4 http://clraindia.org/include/IMPFNewsletterNovember-December2015.pdfJacob PuliyelKeeping Secrets from the PMO Clinical trials are done on human volunteers who participate from altruistic motivations in what could be a dangerous enterprise. Prior informed consent must be obtained after full disclosure of the risks involved. If during the trial, it shows up unacceptable risks, the trial must be stopped. Imagine a trial involving 6 week old infants. Their parents trustingly allow their babies to be experimented on. If the trial shows serious, statistically significant inc Read More... -
PMO plea ignored: Rotavirus vaccine trial results must be made public immediately
Sunday Guardian http://www.sundayguardianlive.com/news/3431-pmo-plea-ignored-rotavirus-vaccine-trial-results-must-be-made-public-immediatelyJacob PuliyelThe trial of the Rotavirus vaccine (called the 116E vaccine) in Vellore, Tamil Nadu, by the Christian Medical College, Vellore, and the Department of Biotechnology of the Government of India, has raised doubts about “ethical standards" in clinical trials. One is reminded of the Tuskegee experiment 40 years ago when black Americans were studied for progression of syphilis, without treatment and without their knowledge. Imagine a trial involving six-week-old infants. Their parents tr Read More... -
PM Modi must rescue vaccine programme from vested interests
Sunday Guardian http://www.sundayguardianlive.com/opinion/3901-pm-modi-must-rescue-vaccine-programme-vested-interestsJacob PuliyelReferences links added PM Modi must rescue vaccine programme from vested interests Sunday Guardian http://www.sundayguardianlive.com/opinion/3901-pm-modi-must-rescue-vaccine-programme-vested-interests Jacob Puliyel Download (PDF) 2.2 MB PM Modi must rescue vaccine programme from vested interests By JACOB PULIYEL | 26 March, 2016 ------------------------------------- To ensure that the public is kept in the dark on formation of public health policy on vaccines the new secretariat Read More... -
Inappropriately Small Sample for Studying Adverse Events Following Immunization
Indian Pediatr 2016;53: 351 http://www.indianpediatrics.net/apr2016/351.pdfKanika Goyal and Jacob PuliyelInappropriately Small Sample for Studying Adverse Events Following Immunization *Kanika Goyal and Jacob Puliyel Department of Pediatrics, St Stephens Hospital, Delhi, India. Email: gyl.knk@gmail.com We refer to the study of common illnesses before and after vaccination [1]. The authors looked for symptoms like constipation, rash, wheeze, rhinitis and watering of eyes in 1602 children in the week after immunization, and found the frequency was same as in the week prior Read More... -
RTI reply of number of deaths following DPT and Pentavalent vaccine in 72 hours 2012-2015 (Penta deaths 249)
No. Z.33013/01/2016-Imm(Pt)Ministry of Health and Family Welfare -
RTI reply to Mr Sanjai Sharma of number fully vaccinated with Pentavalent vaccine and deaths up to July 2014 (Total deaths 76)
No. Z33013/1/2014-CC&VMOH&FW -
RTI reply to J Puliyel on death following Pentavalent and number fully vaccinated (Total deaths 54)
No Z.33013/01/2013-CC&V 16 Dec 2013MOH&FW AEFI Surveillance and Response: Operational Guidelines 2015
https://www.itsu.org.in/repository-resources/AEFI-Surveillance-and-Response-Operational-Guidelines-2015.pdfGovernment of India-
Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study
African Health Sciences Vol 16 Issue 2, June 2016 Page 356 - 62Zainab Mohammedi Golwala, Hardik Shah, Neeraj Gupta, V. Sreenivas, Jacob. M. PuliyelMean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Zainab Mohammedi Golwala1, Hardik Shah1, Neeraj Gupta1, V. Sreenivas2, Jacob. M. Puliyel1 1. Department of Pediatrics and Neonatology, St. Stephens Hospital, New Delhi. 2. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi. Abstract Background: Thrombocytopenia has been shown to predict mort Read More... -
Supreme Court Rotavirus vaccine data disclosure petition
Case No. W.P.(C) No. 289/2016 http://www.livelaw.in/pil-clinical-trial-anti-diarrhea-vaccine-rotavac-sc-issues-notice-centre-dbt-cmc http://www.livelaw.in/pil-clinical-trial-anti-diarrhea-vaccine-rotavac-sc-issues-notice-centre-dbt-cmc-vellore/S Srinivasan Prashant Bhushan -
Vaccine Safety and Efficacy (video presentation) CHD Legal Track: Vaccination Laws around the World - What’s Going on in Asia
https://d3nyygebl2bi65.cloudfront.net/autismone2020.mp4Jacob Puliyel -
DPT Pentavalent vaccine data 2011-2016
Jaspreet Kaur, Ashish Puliyel J Puliyel Thesis as Book: Platelet indices and their ratios: Predictors of pediatric mortality.
2016 LAP Lambert Academic Publishers Saarbruken ISBN 978-3-650-92762-1 Available at www.get-morebooks.comGolwala Z, Puliyel J, Sreenivas V.Golwala Z, Puliyel J, Sreenivas V. Platelet indices and their ratios: Predictors of pediatric mortality. 2016 LAP Lambert Academic Publishers Saarbruken ISBN 978-3-650-92762-1 Available at www.get-morebooks.com-
Good Clinical Practices For Clinical Research In India
http://www.cdsco.nic.in/html/GCP1.htmlCentral Drugs Standard Control Organization (CDSCO)http://www.cdsco.nic.in/html/GCP1.html *Central Drugs Standard Control Organization *Dte.GHS, Ministry of Health and Family Welfare, Government of India *Home <http://www.cdsco.nic.in/index.html>* *Site Map <http://www.cdsco.nic.in/html/sitemap1.htm>* *Archive* *Feedback <http://www.cdsco.nic.in/html/feedback.html>* *Downloads <http://www.cdsco.nic.in/html/downloads.htm>* *Contact <http://www.cdsco.nic.in/ht Read More... -
Infanrix Hexa Periodic Safety Update Report (PSUR) to the EMA Compliments the Findings of Deaths with the Hexavalent Vaccine
http://journals.plos.org/plosone/article/comment?id=info:doi/10.1371/annotation/efe0cd23-f453-4359-9372-0c977bd2c6b3 Response to Sudden Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Series Study Giuseppe Traversa, Stefania Spila-Alegiani , Clara Bianchi, Marta Ciofi degli Atti, Luisa Frova, Marco Massari, Roberto Raschetti, Stefania Salmaso, Gianpaolo Scalia Tomba, and the Hera Study Group PLOS Published: January 26, 2011 http://dx.doi.org/10.1371/journal.pone.0016363Pooja Anthwal, Sonalika Mehta, Jacob PuliyelInfanrix Hexa Periodic Safety Update Report (PSUR) to the EMA Compliments the Findings of Deaths with the Hexavalent Vaccine Posted by Puliyel on 15 Oct 2016 at 10:55 GMT With reference to the paper by Traversa and collaborators (1) we commend the monumental work, their meticulous collection of data and analysis. We however would like to make a few observations about the conclusions they have arrived at especially in the light of contemporaneous global data that has come in to the public doma Read More... -
Rotavirus data Chinu in SC Rejoinder to Counter of GoI
S Srenivasan P Bhushan Neha Rathi Challenges in the investigation of adverse events following immunization. At National Seminar on New Vaccines for All: Why, Which, When. Organised by JSS SAMA NMJI, FMES
https://youtu.be/4aVNKN-dDaIJacob Puliyelhttps://youtu.be/4aVNKN-dDaI Thank you for inviting me for this national seminar on newer vaccines. Slide 2 Chairperson Professor Imrana Quadir and distinguished delegates Challenges in the investigation of adverse events following immunization. I would like to do a quick question with you. I tell you that I am interested in spreading a lie – some falsehood I will divide this audience into two groups. Those to my right I tell you I am willing to pay you 1 rupee every time you Read More...-
Rotavirus data Rejoinder GoI to Chinu in SC
GoI -
237 deaths by Pentavalent vaccine and still counting
Sunday Guardian 13-November 2016. http://www.sundayguardianlive.com/news/7314-237-deaths-pentavalent-vaccine-and-still-countingJacob PuliyelUnder Right to Information we know that up to August 2016 there have been 237 deaths reported to the government here within 72 hours of vaccination with Pentavalent. We examined deaths in states which were giving DPT and Pentavalent vaccine concurrently. There were three deaths following the use of Pentavalent vaccine in Sri Lanka. The Government of Sri Lanka suspended the use of the vaccine. WHO experts investigated the deaths. They found there was a clear temporal association of the deaths Read More... -
High Levels of Natural HBsAb in Newborns in India - Protection Against Hepatocellua\lar Carcinoma?
8th Asian Conference of Pediatric Infectious Disease. 8 to 10 November 2016 Queen Sirkitt National Conference Center Bangkok, ThailandJacob Puliyel, Pathik Naik, Ashish Puliyel, on behalf of the ICMR Hepatitis B Study GroupHigh Levels of Natural HBsAb in Newborns in India - Protection against Hepatocellular Carcinoma *# Jacob Puliyel1, Pathik Naik1, Ashish Puliyel2 1 St Stephens Hospital Delhi India 2 DocuBuzz Computer Solutions 02-12/25, The Franklin, 118223, Singapore, #Puliyel@gmail.com Introduction 4% of Indians is chronic Hepatitis B carriers. Extrapolating data from Taiwan it was estimated that 250,000 die each year of hepatocellular carcinoma (HCC). However, in India the Cancer Registry shows the inc Read More... High Levels of Natural Anti-HBsAb in Newborns in India May Provide Protection against Hepatocellular Carcinoma
https://youtu.be/iBGI4RkH_OQ 8th Asian Congress of Pediatric of Infectious Disease 8th - 10th November 2016 Queen Sirikit National Convention Center Bangkok ThailandJ Puliyel, Pathik Naik, A Puliyel8th Asian Congress of Pediatric of Infectious Disease 8th - 10th November 2016 Queen Sirikit National Convention Center Bangkok Thailand 1. Dr. Beasley was the first to discover of a virus that leads to human cancer. Beasley and his colleagues proved that hepatitis B virus (HBV) is a primary cause of liver cancer, and that a path of transmission is from mothers to infants during childbirth. Working in Taiwan he concluded that 1 in 4 male carries of Hepatitis B would die of hepatocell Read More...-
Don't Trust Me, I Am a Doctor: AEFI and the Breakdown of Regulation
medico friend circle bulletin M FC_Bulletin_Issue_Immunization_371-372.pdf July -November 2016 Available at Link: https://www.dropbox.com/s/6c7sqb0lsv23akc/MFC_Bulletin_Issue_Immunization_371-372.pdf?dl=0 Page 41-43Jacob PuliyelDon’t Trust me, I’m a Doctor: AEFI and the Breakdown of Regulation Jacob M. Puliyel Department of Pediatrics St Stephens Hospital Delhi 110054 puliyel@gmail.com   Don’t Trust me, I’m a Doctor: AEFI and the Breakdown of Regulation In Europe the safety assessment reports on vaccines are filed confidentially with the regulatory authority namely the European Medical Agency (EMA). The Italian court of Justice Nicola Di Leo ordered that the periodic sa Read More... -
Antibiotic Use in Viral Infections May Reduce Empyema But The Associated Risk of Antibiotic Resistance is Unacceptable
PubPeer https://pubpeer.com/publications/084192013B84A8BCE194C683D6473C#fb113357 Response to "Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study" Muriel Le Bourgeois, Agnès Ferroni, Marianne Leruez-Ville, Emmanuelle Varon, Caroline Thumerelle, François Brémont, Michael J Fayon, Christophe Delacourt, Caroline Ligier, Laurence Watier, Didier Guillemot, J. Pediatr., 175 (2016)Rahi Masoom Raza, Neha Dalal, Jacob PuliyelAntibiotic Use in Viral Infections May Reduce Empyema But The Associated Risk of Antibiotic Resistance is Unacceptable The title of the paper by Bourgeois and colleagues "Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children" suggests that antibiotics must be used in viral infections along with NSAID antipyretics. (1) This suggestion is likely to increase irrational use of antibiotics in viral infections and enhan Read More... -
Response of CMC Director to PIL on Rotavirus vaccine trial Vellore data filed by Chinu Shrinivas
Writ 289 of 2016 Supreme Court of IndiaDr Sunil Thomas Chandy Director CMC Vellore -
Casality classification of 132 cases approved by the National AEFI committee 28th June 2016 (Bhopal Madhya Pradesh)
http://www.mohfw.nic.in/showfile.php?lid=4081National AEFI Committeehttp://www.mohfw.nic.in/index1.php?lang=1&level=4&sublinkid=3928&lid=2421 Click on Causality Assessment of 132 Reported serious AEFI Cases, Approved by National AEFI Committee PDF [6185 KB] -
Infanrix hexa PSUR 19 (including PSUR 17, 18 & 19) GSK report to European Medicnes Agency (EMA)
23 October 2011 to 22 October 2014 dated 15 January 2015 obtained obtained by Dr Loretta Bolgan from the EMA under Article 3 of EMA rules and EMA policy on access to documents related to medicinal products for human and veterinary use (EMA 110196/2006 of 30 November 2010).GlaxoSmithKline Biological clinical safety and pharmacovigilance’s confidential report to the EMA -
Correlation of Infant Gender with Postpartum Maternal and Paternal Depression and Exclusive Breastfeeding Rates.
Breastfeed Med. 2017 May 4. doi: 10.1089/bfm.2017.0024. [Epub ahead of print]Goyal K, Purbiya P, Lal SN, Kaur J, Anthwal P, Puliyel JM.Correlation of Infant Gender with Postpartum Maternal and Paternal Depression and Exclusive Breastfeeding Rates AU1c Kanika Goyal, Pragati Purbiya, Sandeep N. Lal, Jaspreet Kaur, Pooja Anthwal, and Jacob M. Puliyel Abstract Introduction: Male bias in India has resulted in an altered sex ratio. It also results in maternal postpartum depression (PPD) and lower breastfeeding rates. We studied depression among fathers in this context. Methods: Edinburgh postnatal depression scale (EPDS) questio Read More... -
Deaths following pentavalent vaccine and the revised AEFI classification
Indian Journal of Medical Ethics Vol II No 4 October-December 2017 Page 300-2. Available at http://ijme.in/articles/deaths-following-pentavalent-vaccine-and-the-revised-aefi-classification/?galley=htmlJ Puliyel, Anand PhadkeDeaths following pentavalent vaccine and the revised AEFI classification Published online on July 4, 2017 We are concerned about the changes effected by the WHO to the assessment methodology of adverse events following immunisation (AEFI)(1), which make it almost impossible to classify adverse events (deaths in this case) noticed for the first time in phase IV post-marketing surveillance, as “consistent causal association to immunisationâ€. The sequence of events leading up to this Read More... -
Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children
Journal of Translational Science http://www.oatext.com/Pilot-comparative-study-on-the-health-of-vaccinated-and-unvaccinated-6-to-12-year-old-U-S-children.phpAnthony R Mawson, Brian D Ray, Azad R Bhuiyan, Binu JacobVaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if an Read More... -
WHA68 16.4 Global vaccine action plan and PHM response
https://docs.google.com/document/d/1Fhwz01-e5VdmOn0FHPKHZCnpxynpDeZSZQW01Swe_3A/edit#heading=h.jpgl32uoyrtu Response of CMC Director to PIL on Rotavirus vaccine trial Vellore data filed by Chinu Shrinivas
https://mail.google.com/mail/u/0/#inbox/15d34056b3fd7392?projector=1Chinu Sreenivasan Prashant BhushanDel Bigtree response to John Oliver's show ridiculing RFKennedy Jr. and the need for vaccine safety
https://youtu.be/igx83myg4WYDel Bigtreehttps://youtu.be/igx83myg4WY-
A study tries to prove efficacy of a rotavirus vaccine that might cause more diarrhoea
https://scroll.in/pulse/844323/a-study-tries-to-prove-efficacy-of-a-rotavirus-vaccine-that-might-cause-more-diarrhoeaJacob PuliyelIn March, the New England Journal of Medicine published the results of a clinical trial of a rotavirus vaccine developed by the Serum Institute of India. The paper highlighted that the vaccine reduced the incidence of rotavirus gastroenteritis and suggested that this new vaccine would be effective in controlling the disease. What the paper tries to gloss over is data from the trial that shows that the overall incidence of diarrhoea among those who received the vaccine actually increased rais Read More... -
Heat-Stable Oral Rotavirus Vaccine
N Engl J Med 2017; 377:302 July 20, 2017DOI: 10.1056/NEJMc1705793 Available at http://www.nejm.org/doi/full/10.1056/NEJMc1705793Jaspreet Kaur, Jacob PuliyelTo the Editor: Isanaka and colleagues (March 23 issue)1 tested a heat-stable rotavirus vaccine in Niger and report an efficacy of 66.7% against severe rotavirus gastroenteritis in the per-protocol population. The purpose of rotavirus vaccination is ultimately to reduce the incidence of diarrhea and diarrhea-related death. However, the rate of severe gastroenteritis due to any cause was not significantly lower among the vaccinated infants than among those who received placebo (difference in ra Read More... -
Enhancing Community Confidence in Vaccines Safety
http://www.bmj.com/content/357/bmj.j2449/rr-6David Legge, Jacob PuliyelFeature US government website for collecting adverse events after vaccination is inaccessible to most users BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2449 (Published 19 May 2017) Cite this as: BMJ 2017;357:j2449 Enhancing Community Confidence in Vaccines Safety The Global Advisory Committee on Vaccine Safety (GACVS) met on 7 and 8 June 2017. WHO’s Executive Board, meeting in January, discussed the report of the mid-term review of the Global Vaccine Action Plan (GVAP) Read More... -
Seeing Voices and Cochlear Implants
http://pediatrics.aappublications.org/content/140/1/e20163489.comments#re-seeing-voices-and-cochlear-implantsSara Varughese, Pooja Anthwal, Jacob M. Puliyel15 August 2017 RE: Seeing Voices and Cochlear Implants Sara Varughese, Regional Director Christoffel Blindenmission (CBM), 140 Commerce Cube, Bangalore 560018 India Other Contributors: Pooja Anthwal, Resident in Pediatrics Jacob M. Puliyel, Pediatrician and Head of Department of Pediatrics Geers and colleagues, in a meticulously executed study, reported a delay in speech acquisition in patients using sign language prior to cochlear implantation (1). We fear that Read More... -
With Pneumococcal Vaccine Patent, Pfizer Wins on Many Counts
The Wire https://thewire.in/170941/pfizer-pneumonia-vaccine-patent/Jacob PuliyelWith Pneumococcal Vaccine Patent, Pfizer Wins on Many Counts By Jacob Puliyel on 25/08/2017 Not only was Pfizer given a subsidy to ‘develop’ a drug that already existed, the profits they will make from the inefficient vaccine is much beyond what was originally stipulated. A company logo is seen through branches at a Pfizer office in Dublin, Ireland November 24, 2015. Credit: Reuters/Cathal McNaughton A company logo is seen through branches at a Pfizer office in Dublin, Irel Read More... -
Platelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness
Indian J Pediatr Published online 26 August 2017 DOI 10.1007/s12098-017-2432-zPragati Purbiya, Zainab Mohammedi Golwala, Ayush Manchanda, V. Sreenivas, Jacob M. PuliyelPlatelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness Pragati Purbiya 1,2✉ EmailPrags.89@gmail.com Zainab MohammediGolwala1 Ayush Manchanda 1 V. Sreenivas 3 Jacob M. Puliyel 1 1Department of PediatricsSt Stephens HospitalTis HazariDelhiIndia 2B-39, Sudama NagarIndoreMadhya Pradesh452009India 3Department of BiostatisticsAll India Institute of Medical SciencesNew DelhiIndia Abstract Objective To prospectively validate association between the ratio Read More... -
Infanrix hexa and sudden death: a review of the periodic safety update reports submitted to the European Medicines Agency
Indian Journal of Medical Ethics http://ijme.in/articles/infanrix-hexa-and-sudden-death-a-review-of-the-periodic-safety-update-reports-submitted-to-the-european-medicines-agency/?galley=htmlJacob Puliyel, SathyamalaCOMMENT Infanrix hexa and sudden death: a review of the periodic safety update reports submitted to the European Medicines Agency Jacob Puliyel, C Sathyamala Published online: September 5, 2017 Abstract There have been a number of spontaneous reports of sudden unexpected death soon after the administration of Infanrix hexa (combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliomyelitis and Haemophilus influenza type B vaccine). The manufacturer, GlaxoSmithKlin Read More... -
Continuous Positive Airway Pressure in Bronchiolitis: A Randomized Controlled Trial
Indian Pediatr. 2018 Jan 15;55(1):27-30. http://indianpediatrics.net/e-pub.htmSANDEEP NARAYAN LAL, JASPREET KAUR, POOJA ANTHWAL, KANIKA GOYAL, PINKY BAHL AND JACOB M PULIYELABSTRACT Objective: To evaluate the efficacy of nasal continuous positive airway pressure (nCPAP) in decreasing respiratory distress in bronchiolitis. Design: Randomized controlled trial. Setting: Tertiary-care hospital in New Delhi, India. Participants: 72 infants (age <1y) hospitalized with a clinical diagnosis of bronchiolitis were randomized to receive standard care, or nCPAP in addition to standard care, in the first hour after admission. 23 parents refused to give consent for participat Read More... -
Cost-Effectiveness Calculations of Human Papillomavirus Vaccination in Punjab May Be Flawed
Cancer. 2018 Jan 1;124(1):213-214 DOI: 10.1002/cncr.31075, Published online Month 00, 2017Vivian Suman, Jacob M. Puliyel,Cost-Effectiveness Calculations of Human Papillomavirus Vaccination in Punjab May Be Flawed Prinja et al1 looked at the cost-effectiveness of the human papillomavirus (HPV) vaccine for adolescent girls in Punjab, India. They assumed that the cost of vaccination would be US $14.1 per child. The report suggests a 90% probability that vaccination would be cost-effective in Punjab (at a willingness-to-pay threshold of 10,000 Indian rupees per quality-adjusted life-year gained, which is one-tenth o Read More... -
The Reply to the letter on the cost-effectiveness of human papillomavirus in Punjab further distorts the scientific record
Cancer. 2018 Mar 1;124(5):1085 Version of Record online: 22 NOV 2017 | DOI: 10.1002/cncr.31167Vivian Suman and Jacob M. PuliyelThe Reply to the Letter on the Cost-Effectiveness of Human Papillomavirus in Punjab Further Distorts the Scientific Record Articles in peer-reviewed scientific journals become part of the scientific record. For this reason, the correspondence column opens up the science to wider peer review as part of the effort to uphold the scientific validity of published science. We are concerned that the reply about the cost-effectiveness of human papillomavirus vaccination in Punjab1 is not entir Read More... -
Dubious vaccine for cervical cancer
http://www.tribuneindia.com/news/in-focus/dubious-vaccine-for-cervical-cancer/518412.htmlJacob PuliyelTribune Monday, December 25, 2017 In Focus Posted at: Dec 25, 2017, 12:53 AM; last updated: Dec 25, 2017, 12:12 PM (IST) Dubious vaccine for cervical cancer Also in this section Prevention is better than cure Dubious vaccine for cervical cancer Jacob Puliyel Before a new vaccine is introduced it is first studied in a randomised controlled trial where some are given the drug and others are given an inert substance to check the effects and adverse effects among those given the Read More... -
Evaluation of the Protection Provided by Hepatitis B Vaccination in India.
The Indian Journal of Pediatrics, 85(7), 510-516 http://rdcu.be/EpEZPuliyel J, Naik P, Puliyel A, Agarwal K, Lal V, Kansal N, Nandan D, Tripathi V, Tyagi P, Singh SK, Srivastava R, Sharma U, Sreenivas V.Evaluation of the Protection Provided by Hepatitis B Vaccination in India Abstract In India Hepatitis B vaccination is recommended at 6 weeks except for hospital-deliveries. We examined protection afforded by the birth dose. Method A case-control study was done. HBsAg and HBcAb were tested in 2671 children 1 to 5 years and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis children who got infected (HBsAg and/o Read More... -
If OSCE is not a valid test of Clinical Skills-What Next?
NBE Bulletin Volume 1 Number 3 Oct-December, 2005 Page 4Jacob Puliyel -
Comment on Article ;The vaccine mandates judgment: Some reflections S Srinivasan' https://doi.org/10.20529/IJME.2022.056 in Ind Journal of Medical Ethics
https://ijme.in/articles/the-vaccine-mandates-judgment-some-reflections/?galley=htmlJacob PuliyelComments: Jacob Puliyel Visiting Professor, International Institute of Health Management Research Delhi , India 31 July 2022 I thank Srinivasan for his well-researched article. I however think he has over-interpreted what he calls ‘Proposition A’ He writes “The binary classification of vaccinated and unvaccinated groups of individuals, with respect to risks from virus transmission in Proposition A is too simplistic considering there is a range of poss Read More... -
Ambitious health care benefits: Winning votes while protecting public health
http://www.delhipost.live/ambitious-health-care-benefits-winning-votes-protecting-public-health/Jacob PuliyelAmbitious health care benefits: Winning votes while protecting public health By Dr. Jacob Puliyel - on February 7, 2018 31 0 The recently announced enhanced benefits under the NHPS without allocating any money for it is an excellent move in ensuring that private sector is not preferred over public sector. Data from the 70th round of theNational Sample Survey on ‘Household Indebtedness’ shows that nearly one in three rural households and over one in five urban households are Read More... -
Doublespeak is not 'post truth': It is Orwellian
https://www.bmj.com/content/365/bmj.l1932/rr-12 Rapid Response BMJ to https://www.bmj.com/content/365/bmj.l1932/rr-8Jacob PuliyelDoublespeak is not 'post truth': It is Orwellian F. Scott Fitzgerald is quoted to have said “The test of a first-rate intelligence is the ability to hold two opposed ideas in mind at the same time and still retain the ability to function.†I got a glimpse of this while reading the response of Jonathan J Kennedy. Kennedy has agreed with everything the earlier correspondents Allan Cunningham, Elizabeth Hart, John Stone, Noel Thomas and JK Anand have written but contrad Read More... -
The New WHO Causality Assessment Algorithm Needs Revision to Restore Public Trust
https://www.bmj.com/content/365/bmj.l2268/rr-0 Response to Modernising vaccine surveillance systems to improve detection of rare or poorly defined adverse events BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l2268Jacob Puliyel -
AutismOne talk Chicago May 2019
https://www.youtube.com/watch?v=1o_6XVWsRigJacob Puliyel -
Vaccine in Safety Italy
https://www.youtube.com/watch?v=L_I8remugnQJacob Puliyel -
Mean core to peripheral temperature difference and mean lactate levels in first 6 hours of hospitalisation as two indicators of prognosis: an observational cohort study
BMC Pediatrics volume 20, Article number: 515 (2020) https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02418-wAashish Gupta, Jacob Puliyel, Bhawana Garg & Pramod UpadhyayBackground To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children. Methods A prospective observational study in a tertiary level Pediatrics ICU in Delhi, India. Seventy eight paediatric patients from 1 month to 12 years were studied. Children with physical trauma, post-surgical patients and patients with peripheral vascular disease were Read More... -
Can the Uppsala Monitoring Centre Evaluate India-Government Data on Deaths with Pentavalent Vaccine to Restore Public Trust
https://www.bmj.com/content/365/bmj.l2268/rr-10Jacob Puliyel -
Vaccine policy of the Government of India : Driven and controlled by vested interests.
In Universalising health care in India: From care to coverage. Editors Imrana Qadeer, K B Saxena, P M Arathi. Aakar Books 2019 Delhi ISBN 978-93-5002-588-8 Page 287 - 310Puliyel J -
Hand Grip Strength and Evidence Based Medicine
https://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/cbee7325-3eec-46a3-b128-1c8bb6372987Kartiki K, PuliyelResponse to Redesigning care for older people to preserve physical and mental capacity: WHO guidelines on community-level interventions in integrated care Jotheeswaran Amuthavalli Thiyagarajan , Islene Araujo de Carvalho , Juan Pablo Peña-Rosas, Shelly Chadha, Silvio Paolo Mariotti, Tarun Dua, Emiliano Albanese, Olivier Bruyère, Matteo Cesari, Alan Dangour, Amit Dias, Mariella Guerra, Jill Keeffe, [ ... ], John R. Beard [ view all ] Published: October 18, 2019https://doi.org/10 Read More... -
‘Unethical’ clinical trials of vaccines pose threat to human lives
Sunday Guardian Online before print https://www.sundayguardianlive.com/news/unethical-clinical-trials-vaccines-pose-threat-human-livesJacob Puliyel‘Unethical’ clinical trials of vaccines pose threat to human lives Jacob Puliyel Published : November 11, 2019, 10:54 am | Updated : November 11, 2019, 10:54 AM Primum non nocere "first, do no harm" is a basic tenet of medical ethics. That is about to change in India. It is planned to introduce “Controlled Human Infection Method†(CHIM) studies here. Humans are to be deliberately infected with diseases to test the efficiency of experimental vacc Read More... -
White Paper: Safety of Rotavirus Vaccine in India. Smart Safety Surveillance Approach
https://www.worldsdg2030.org/images/White-paper-Book.pdf Also Research Gate DOI 10.13140/RG.2.2.15881.60007 -
Mother-to-Child Transfer of Reactivated Varicella-ZosterVirus DNA and Varicella-Zoster IgG in Pregnancy
Viral Immunol. 2019 Dec 13. doi: 10.1089/vim.2019.0090. [Epub ahead of print] PMID: 31834852 doi.org/10.1089/vim.2019.0090Ranjan V, Mishra A, Kesarwani A, Mohan KV, Lal SN, Puliyel J, Upadhyay P.Mother-to-Child Transfer of Reactivated Varicella-ZosterVirus DNA and Varicella-Zoster IgG in PregnancyVivek Ranjan,1Alaknanda Mishra,2Ashwani Kesarwani,2K. Varsha Mohan,2Sandeep Narayan Lal,1Jacob Puliyel,1and Pramod Upadhyay2 1Department of Pediatrics, St. Stephens Hospital, New Delhi, India.2National Institute of Immunology, New Delhi, India.VIRAL IMMUNOLOGYVolume 00, Number 00, 2019ªMary Ann Liebert, Inc.Pp. 1–5DOI: 10.1089/vim.2019.009 AbstractStress-induced subclinical reactivat Read More... -
Coronavirus Pandemic: Is It Time to Wind Down the Rhetoric?
https://thewire.in/health/coronavirus-pandemic-covid-19-lockdown-mortality-public-health-hydroxochloroquine-icmr-panicJacob Puliyel -
Why COVID-19 can—and should—change how our cities are designed
The Caravan 4 May 2020 https://caravanmagazine.in/health/why-covid-19-and-should-change-how-our-cities-are-designedNia Puliyel -
Are You Becoming Lonelier? Your City Might Be Part of the Problem.
The Wire 23/JAN/2020 https://thewire.in/urban/urban-loneliness-social-architecture-senior-living-student-housingNia Puliyel -
Dose Related Toxicity of Hydroxychloroquine
https://www.bmj.com/content/370/bmj.m2670/rr-1Jacob Puliyel -
Gresham’s Law and the Covid-19 pandemic
Sunday Guardian https://www.sundayguardianlive.com/news/greshams-law-covid-19-pandemicJacob PuliyelGresham’s Law and the Covid-19 pandemic Jacob Puliyel • Published June 29, 2020, 11:04 am • | • Updated • June Gresham’s law holds that bad money drives out good money. If there are two coins with the same face value, but of different intrinsic value (assume that one is made of a more precious metal) the coin with less intrinsic worth (bad coin) will be used for currency transactions and the more valuable coin will go out of circulatio Read More... -
Blog Extract from The Caravan: Why COVID-19 can—and should—change how our cities are designed
Extract on Perkins Eastman Blog page https://medium.com/@humanbydesign.perkinseastman/why-covid-19-can-and-should-change-how-our-cities-are-designed-11d09cd9e449https://medium.com/@humanbydesign.perkinseastman/why-covid-19-can-and-should-change-how-our-cities-are-designed-11d09cd9e449ia Puliyel -
Redefining Vaccine Reactions to Erase Evidence of harm: Presentation at the 5th International Public Conference on Vaccination of National Vaccine Information Centre
https://d3nyygebl2bi65.cloudfront.net/s-NVIC_PULIYEL_JACOB.mp4Jacob Puliyel -
PIL Supreme Court of India For vaccine data transparency and against mandating vaccination
https://d3nyygebl2bi65.cloudfront.net/WritPetition-combined.pdfJacob Puliyel, Prashant Bushan -
FEATURES What buildings can teach human body about stability
The Tribune https://www.tribuneindia.com/news/features/what-buildings-can-teach-human-body-about-stability-281545Nia Puliyel -
Supreme Court of India additional affidavit For vaccine data transparency and against mandating vaccination
Prashant Bhushan, Cheryl D Souza, Jacob Puliyel -
Supreme Court of India additional affidavit 289 of 2016 Rotavirus vaccine trial data
SC 289 of 2016S Srinivasan Prashant Bhushan Neha RatiSECTION: PIL IN THE SUPREME COURT OF INDIA (CIVIL ORIGINAL JURISDICTION) WRIT PETITION (CIVIL) NO. 289 OF 2016 IN THE MATTER OF: S. SRINIVASAN …. PETITIONER VERSUS UNION OF INDIA & ORS RESPONDENTS FILING INDEX S.NO. PARTICULARS COPIES C.FEE 1. ADDITIONAL AFFIDAVIT ON BEHALF OF THE PETITIONER 1 20/- 2. ANNEXURE P1 TO P5 1 NIL NEW DEHI: DATED: 20.07.2021 (PRASHANT BHUSHAN) COUNSEL FOR THE PETITIONERS 301, NEW LAWYERS CHAMBERS SUPREME COURT OF Read More... -
Supreme Court of India additional affidavit 2 For vaccine data transparency and against mandating vaccination PIL WRIT PETITION (CIVIL) NO. 607 OF 2021
Supreme Court PIL WRIT PETITION (CIVIL) NO. 607 OF 2021 IA no. 110625/2021Prashant Bhushan, Cheryl D Souza, Jacob Puliyel -
Like Icarus, are we flying too close to the sun with a DNA vaccine against COVID-19?
Caravan 20 September 2021 https://caravanmagazine.in/health/the-little-discussed-risks-of-dna-vaccines-against-covid19Jacob M Puliyel -
The Covid Lockdown and School Closures in India Education for All. Inclusive Education Benefits All Children
Global Research, September 30, 2021 https://www.globalresearch.ca/education-all-inclusive-education-benefits-all-children/5757264Sara VarugheseThe Covid Lockdown and School Closures in India Education for All. Inclusive Education Benefits All Children By Sara Varughese Global Research, September 30, 2021 Theme: Poverty & Social Inequality print 1 0 0 2 All Global Research articles can be read in 51 languages by activating the “Translate Website†drop down menu on the top banner of our home page (Desktop version). Visit and follow us on Instagram at @crg_globalresearch. *** Several Read More... -
Transforming Cities: Story of Two Roads in Delhi
Delhi Post 15 October 2021 https://delhipostnews.com/transforming-cities-story-of-two-roads-in-delhi/Sara VarugheseDelhi Chief Minister Arvind Kejriwal’s advertisement says, “How will Delhi’s streets become like those of Europe.†This was a full-page advertisement by the Delhi government for a workshop on transforming Delhi’s streets. The advertisement had a background picture of the newly renovated Chandni Chowk. With brutal honesty and reality, in the foreground of the picture lay an adult helping his child to ease himself on the roadside. A visit to Chandni Chowk in mid Read More... -
Supreme Court of India additional affidavit 3 (4th affidavit in case) For vaccine data transparency and against mandating vaccination PIL WRIT PETITION (CIVIL) NO. 607 OF 2021
Supreme Court PIL WRIT PETITION (CIVIL) NO. 607 OF 2021 IA no. 110625/2021Prashant Bhushan, Cheryl D Souza, Jacob PuliyelSECTION: PIL IN THE SUPREME COURT OF INDIA (CIVIL ORIGINAL JURISDICTION) WRIT PETITION (CIVIL) NO. 607 OF 2021 IN THE MATTER OF: DR. JACOB PULIYEL ...PETITIONERS VERSUS UNION OF INDIA & ANR. …RESPONDENTS FILING INDEX S.NO. PARTICULARS COPIES 1. ADDITIONAL AFFIDAVIT ON BEHALF OF THE PETITIONER 1 2. ANNEXURE A1 TO ANNEXURE A3 1 NEW DEHI: DATED: 26.11.2021 (PRASHANT BHUSHAN) COUNSEL FOR THE PETITIONER 301, NEW LAWYERS CHAMBERS SUPREME COUR Read More... -
Supreme Court of India Rejoinder to response from GoI additional affidavit 4 (5th affidavit in case) For vaccine data transparency and against mandating vaccination
PIL WRIT PETITION (CIVIL) NO. 607 OF 2021Prashant Bhushan Cheryl D'Souza Jacob Puliyel -
Supreme Court of India Application to Implead States with vaccine mandates For vaccine data transparency and against mandating vaccination Prashant Bhushan Cheryl D'Souza Jacob Puliyel PIL WRIT PETITION (CIVIL) NO. 607 OF 2021
Prashant Bhushan Jacob Puliyel -
Supreme Court of India Application for Directions on Vaccine for Children For vaccine data transparency and against mandating vaccination Prashant Bhushan Cheryl D'Souza Jacob Puliyel PIL WRIT PETITION (CIVIL) NO. 607 OF 2021
Prashant Bhushan Cheryl DeSouza -
Tamil Nadu Response to Supreme Court of India. PIL For vaccine data transparency and against mandating vaccination
-
-
Supreme Court of India TO THE CASE LAW COMPILATION FILED BY THE UOI. Case against vaccine mandates and for at a transparency
Prashant Bushan Cheryl D Souza -
Supreme Court of India REJOINDER AFFIDAVIT ON BEHALF OF THE PETITIONER TO THE COUNTER AFFIDAVIT FILED BY RESPONDENT NO. 1 & 2 Case against vaccine mandates and for at a transparency
P Bhushan Cheryl DSouza Puliyel -
Supreme Court of India Rejoinder to Science UoI Case against vaccine mandates and for at a transparency
-
Supreme Court of India Final arguments response to THE UOI. Case against vaccine mandates and for at a transparency
-
Government Response to Supreme Court of India. PIL For vaccine data transparency and against mandating vaccination RESPONDENT NO. 1 (MINISTRY OF HEALTH AND FAMILY WELFARE) AND RESPONDENT NO 2. (CENTRAL DRUGS STANDARD CONTROL ORGANISATION)
-
Crossing Borders: An Enigma for Humans
Delhi Post http://t.ly/o0YaSara Varughese -
Supreme Court Judgement Covid Vaccine Mandate AEFI reporting
https://www.livelaw.in/pdf_upload/vaccinemandate-416470.pdfL. NAGESWARA RAO, J.; B. R. GAVAI. -
Peer review for Bellavite P. (2020). Causality assessment of adverse events following immunization: the problem of multifactorial pathology. F1000Research, 9, 170. https://doi.org/10.12688/f1000research.22600.2
Puliyel J -
Health Insurance: Drawing inspiration from chit funds to pool health risks efficiently
Jacob M Health Insurance: Drawing inspiration from chit funds to pool health risks efficiently. Indian Journal of Medical Ethics, [S.l.], v. VIII, n. 3, p. 255, jan. 2023. ISSN 0975-5691. Avaialble at:Jacob PuliyelHealth Insurance: Drawing inspiration from chit funds to pool health risks efficiently Published online first on January 20, 2023. DOI: 10.20529/IJME. 2023.009 Keywords: out of pocket expenses, catastrophic health expenditure, Rashtriya Swastha Bhima Yojana, ROSCA, adverse selection, co payments The provision of government-funded public health services in India is grossly inadequate and 48.2% of “total health expenditure” for India is paid “out of pocket” [1]. When the total he Read More... - https://f1000research.com/articles/9-170/v1#referee-response-61073
-
Right to self-determine what may be injected into our bodies is fundamental, says petitioner in the vaccination case in the Supreme Court
The Leaflet https://theleaflet.in/right-to-self-determine-what-may-be-injected-into-our-bodies-is-fundamental-says-petitioner-in-the-vaccination-case-in-the-supreme-court/Sarah Thanawala, J Puliyel -
Gall Bladder Wall Edema is Not Pathogenic of Dengue Infection
J Trop Pediatr . 2002 Oct;48(5):315-6.Anupam Sehgal, Sangita Gupta, Vineet Tyagi, Shubhra Bahl, Saroj K Singh, Jacob M PuliyelRESEARCH LETTERS Journal of Tropical Pediatrics Vol. 48 October 2002 315 FIG. 1. Distribution of gallbladder wall edema in children with a fever of 101ºF for 5 days or more. Gall Bladder Wall Edema is Not Pathogenic of Dengue Infection We have previously reported gall bladder wall edema (GBWE) in serology-proven pediatric dengue hemorrhagic fever (DHF).1 Contemporane- ously, Setiwan, et al.2 reported GBWE in 94 out of 148 serologically-proven dengue cases. However is GBWE pathognomic Read More... -
The very low response rate to this survey militates against the validity of the findings. Response to Gao G, Lang R, Oxoby RJ, et al. Drivers of downloading and reasons for not downloading COVID-19 contact tracing and exposure notification apps: A national cross-sectional survey. PLoS One. 2022 Jul 15;17(7):e0269783.
https://journals.plos.org/plosone/article/comment?id=10.1371/annotation/7a00e4c1-a526-4802-86f6-05343967519fSheetal Surjeet, Deepali Bhardwaj, Jacob Puliyel.Sir We commend the authors for their effort to find out why Canadians are not downloading COVID contact tracing apps. However, their effort to interrogate a representative sample of the population was frustrated by public suspicion or apathy which may have been the reason for the low uptake of the software in the first place. Although the authors write that the response rate was 36%, only 4503 of the 14887 completed the questionnaire and the real response rate was only 30.24%. This must hav Read More... Good Morning CHD Episode 160: Health Freedom Winning in India
https://live.childrenshealthdefense.org/shows/good-morning-chd/fI-umbyMn5Mary Holland, Jacob Puliyel, Dipali Ojha-
Socio-Demographic Factors May Need Addressing to Improve the Survival of Neonates Response to Deorari AK, Kumar P, Chawla D, Thukral A, Goel S, Bajaj R, Singh M, Gilbert C, Shukla R; Retinopathy of Prematurity-Quality Improvement India Study Group. Improving the Quality of Health Care in Special Neonatal Care Units of India: A Before and After Intervention Study. Glob Health Sci Pract. 2022 Oct 31;10(5):e2200085.
https://www.ghspjournal.org/content/10/5/e2200085/tab-e-letters#socio-demographic-factors-may-need-addressing-to-improve-the-survival-of-neonates-Nida Shaikh, Tanya Singh, Sheetal Surjeet, Deepali Bhardwaj and Jacob Puliyel -
The COVID-19 Vaccine Story. The abandonment of process, protocol and the scientific method
Page 20 to 31 State of Finance In India 2021-22. Focus on the Global South, Centre for Financial Accountability, Economic Research Foundation. Yoda Press New Delhi 49Jacob Puliyel -
We do not need more International Health Regulations - It is the WHO that needs to reform. Response to Between rules and resistance: moving public health emergency responses beyond fear, racism and greed
https://gh.bmj.com/content/7/12/e009945.responses. Jackson C, Habibi R, Forman L, et al Between rules and resistance: moving public health emergency responses beyond fear, racism and greed BMJ Global Health 2022;7:e009945.Jacob Puliyel Susanth George Thomas -
Prevention of avoidable blindness is a social imperative: Facile economic models do not help.
https://journals.lww.com/ijo/Fulltext/2023/71060/Prevention_of_avoidable_blindness_is_a_social.58.aspx Indian J Ophthalmol. 2023 Jun;71(6):2605. doi: 10.4103/IJO.IJO_3142_22. PMID: 37322695.Singh M, Bhardwaj D, Singh T, Kaushik T, Puliyel J.Prevention of avoidable blindness is a social imperative: Facile economic models do not help Singh, Manoj; Bhardwaj, Deepali; Singh, Tanya; Kaushik, Tanuj; Puliyel, Jacob Author Information Indian Journal of Ophthalmology 71(6):p 2605, June 2023. | DOI: 10.4103/IJO.IJO_3142_22 Open Dear Editor, Economic models built by aggregating assumptions yield only a new set of assumptions, and these cannot be relied upon, except to the extent that they provide verifiable data points. The Read More... -
The Scientific Record: Examining Some of the Claims and Counterclaims in the MMR Saga
Preprint. https://www.preprints.org/manuscript/202303.0401/v1Puliyel JThe Scientific Record: Examining some of the claims and counterclaims in the MMR saga Comparison of the Lancet with the BMJ The claim the Lancet paper reported 9 children with ‘regressive autism’ is incorrect. Concerning these children, the term 'regressive autism' is used only in the BMJ. The Lancet explicitly states that the diagnosis of ‘autism’ was made earlier elsewhere before admission. Lancet: '…all had been assessed professionally elsewhere, so these asses Read More... -
Gender-based Violence in an Indian Resettlement Colony Threatened with Re-eviction
Medical Journal of Dr. D.Y. Patil Vidyapeeth 17(4):p 824-832, Jul–Aug 2024. | DOI: 10.4103/mjdrdypu.mjdrdypu_651_23 https://journals.lww.com/mjdy/fulltext/2024/17040/gender_based_violence_in_an_indian_resettlement.21.aspxSurjeet, Sheetal; Maji, Ishita; Khan, Yasmin; Chaudhuri, Swadhapriya D.; Punia, Jagriti; Ruhil, Rohini; Puliyel, JacobIntroduction: Od tribals who migrated to India during the Indo-Pakistan partition of 1947 were resettled by the Government of India in 1987 in the Bhatti Mines area near Delhi, India. However, in 1991, the area was declared a wildlife sanctuary, and the tribals were threatened with eviction a second time. We studied gender-based violence (GBV) in this community subjected to repeated displacement. Materials and Methods: A systematic randomized sample of 200 households was studied. The Read More...
