2016 LAP Lambert Academic Publishers Saarbruken ISBN 978-3-650-92762-1 Available at www.get-morebooks.com
Golwala Z, Puliyel J, Sreenivas V.
Golwala Z, Puliyel J, Sreenivas V. Platelet indices and their ratios: Predictors of pediatric mortality. 2016 LAP Lambert Academic Publishers Saarbruken ISBN 978-3-650-92762-1 Available at www.get-morebooks.com
https://f1000research.com/articles/9-170/v1#referee-response-61073
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Conference Abstract: Mathematical and Computational Medicine Conference 2012
Signe Svane, Ellen Marie Møldrup, Ashish Puliyel and Jacob Puliyel*
Monitoring RCT using CUSUM Can Save Lives
Signe Svane,a Ellen Marie Møldrup,a Ashish Puliyelb and Jacob Puliyelc*
a Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Denmark.
b #07-130, GonzoBuzz LLP, Singapore 350139
c Department Pediatrics, St Stephens Hospital, Delhi, 110054,India.
Cumulative sum (CUSUM) is a statistical technique used in industry for quality control. Objective: The aim of this study is to test if CUSUM can be useful in the context of Read More... -
http://www.icmr.nic.in/minutes/Minutes%20Core%20Committee%20on%20Vaccines.pdf
Government of India Core Committee
Data on disease surveillance in Kerala
for 1999-2000 (John et al. 2004) showed 75
meningitis cases of which at least 27 were bacterial meningitis. Assuming that one
third of this is due to Hib, for a 26 milli
on birth cohort, the estimated Hib meningitis
is 52000 per year. Using the validated Hib
Rapid Assessment Tool estimates, that
allows pneumonia burden estimates based on meningitis data, the estimated Hib
pneumonia cases would be 260000 per year (WHO 2001).
John TJ, Rajappan K, Ar Read More... -
RTI
GoI
RTI document GAVI will withdraw Rs 530 crores alloted to India if India does not extend Pentavalent to 6 more states (against NTAGI recommendation of trial in 2 states. Government will have to spend Rs 1370 crores to get GAVI 530 crores
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http://www.icmr.nic.in/minutes/Minutes%20Expert%20Group%20%20Hepatitis%20B%20and%20Hib%20vaccines.pdf
A study on HBV disease profile based on liv
er biopsy of consecutive patients who
were HbsAg positive presenting to AIIMS from Jan. 2008 to June 2009,showed
that 80% are silent infections. 44% of
the patients were asymptomatic healthy
carriers, 13% were immunotolerant, 28%
were HBeAg positive chronic hepatitis 7
and 15% were HBeAg negative chronic
hepatitis (Data from AIIMS:personal
communication Dr.S.K.Acharya).

Based on the natural course of the HBV
infecti Read More... -
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NTAGI GoI
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NTAGI GoI
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http://bit.ly/npsi_data
Puliyel J
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NTAGI Subcommittee
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http://www.ncbi.nlm.nih.gov/myncbi/jacob.puliyel.1/comments/
Jacob Puliyel
http://www.ncbi.nlm.nih.gov/myncbi/jacob.puliyel.1/comments/
PubMed
US National Library of Medicine National Institutes of Health
Search database
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Jacob Puliyel
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• Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.
Baldo Read More... -
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Data used for Trends in Non-Polio AFP published in abstract in Pediatrics. 2015 Feb;135 Suppl 1:S16-7. doi: 10.1542/peds.2014-3330DD. PMID: 25646230
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Disabil Health J. 2018 Oct 16. pii: S1936-6574(18)30198-5. doi: 10.1016/j.dhjo.2018.10.003.
Rahul Mopari, Bhawna Garg, Jacob Puliyel, Sara Varughese
Measuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire
Rahul Mopari1 rahulm.doc@gmail.com
Bhawna Garg2 CFA thestatisticalanalyst@gmail.com
Jacob Puliyel1 puliyel@gmail.com
Sara Varughese3 sara.varughese@cbm.org
1. St Stephens Hospital Delhi,
2. Independent Statistician. 135 Bhagirathi, Sector 9, Rohini, Delhi
3. CBM India Liaison Office, Bangalore.
Address for communication
Sara Varughese FRCS
Country Director
CBM India
#140, &aci Read More... -
No. Z.33013/01/2016-Imm(Pt)
Ministry of Health and Family Welfare
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No. Z33013/1/2014-CC&V
MOH&FW
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No Z.33013/01/2013-CC&V 16 Dec 2013
MOH&FW
https://www.itsu.org.in/repository-resources/AEFI-Surveillance-and-Response-Operational-Guidelines-2015.pdf
Government of India
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Case No. W.P.(C) No. 289/2016 http://www.livelaw.in/pil-clinical-trial-anti-diarrhea-vaccine-rotavac-sc-issues-notice-centre-dbt-cmc http://www.livelaw.in/pil-clinical-trial-anti-diarrhea-vaccine-rotavac-sc-issues-notice-centre-dbt-cmc-vellore/
S Srinivasan Prashant Bhushan
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Jaspreet Kaur, Ashish Puliyel J Puliyel
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http://www.cdsco.nic.in/html/GCP1.html
Central Drugs Standard Control Organization (CDSCO)
http://www.cdsco.nic.in/html/GCP1.html
*Central Drugs Standard Control
Organization
*Dte.GHS, Ministry of Health and Family Welfare, Government of India
*Home <http://www.cdsco.nic.in/index.html>*
*Site Map <http://www.cdsco.nic.in/html/sitemap1.htm>*
*Archive*
*Feedback <http://www.cdsco.nic.in/html/feedback.html>*
*Downloads <http://www.cdsco.nic.in/html/downloads.htm>*
*Contact <http://www.cdsco.nic.in/ht Read More... -
http://www.mohfw.nic.in/showfile.php?lid=4081
National AEFI Committee
http://www.mohfw.nic.in/index1.php?lang=1&level=4&sublinkid=3928&lid=2421
Click on
Causality Assessment of 132 Reported serious AEFI Cases, Approved by National AEFI Committee PDF [6185 KB]
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23 October 2011 to 22 October 2014 dated 15 January 2015 obtained obtained by Dr Loretta Bolgan from the EMA under Article 3 of EMA rules and EMA policy on access to documents related to medicinal products for human and veterinary use (EMA 110196/2006 of 30 November 2010).
GlaxoSmithKline Biological clinical safety and pharmacovigilance’s confidential report to the EMA
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Journal of Translational Science http://www.oatext.com/Pilot-comparative-study-on-the-health-of-vaccinated-and-unvaccinated-6-to-12-year-old-U-S-children.php
Anthony R Mawson, Brian D Ray, Azad R Bhuiyan, Binu Jacob
Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if an Read More... -
https://docs.google.com/document/d/1Fhwz01-e5VdmOn0FHPKHZCnpxynpDeZSZQW01Swe_3A/edit#heading=h.jpgl32uoyrtu
https://mail.google.com/mail/u/0/#inbox/15d34056b3fd7392?projector=1
Chinu Sreenivasan Prashant Bhushan
https://youtu.be/igx83myg4WY
Del Bigtree
https://youtu.be/igx83myg4WY
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The Caravan 4 May 2020 https://caravanmagazine.in/health/why-covid-19-and-should-change-how-our-cities-are-designed
Nia Puliyel
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The Wire 23/JAN/2020 https://thewire.in/urban/urban-loneliness-social-architecture-senior-living-student-housing
Nia Puliyel
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Extract on Perkins Eastman Blog page https://medium.com/@humanbydesign.perkinseastman/why-covid-19-can-and-should-change-how-our-cities-are-designed-11d09cd9e449
https://medium.com/@humanbydesign.perkinseastman/why-covid-19-can-and-should-change-how-our-cities-are-designed-11d09cd9e449ia Puliyel
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The Tribune https://www.tribuneindia.com/news/features/what-buildings-can-teach-human-body-about-stability-281545
Nia Puliyel
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Global Research, September 30, 2021 https://www.globalresearch.ca/education-all-inclusive-education-benefits-all-children/5757264
Sara Varughese
The Covid Lockdown and School Closures in India
Education for All. Inclusive Education Benefits All Children
By Sara Varughese
Global Research, September 30, 2021
Theme: Poverty & Social Inequality
print
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All Global Research articles can be read in 51 languages by activating the “Translate Website†drop down menu on the top banner of our home page (Desktop version).
Visit and follow us on Instagram at @crg_globalresearch.
Read More... -
Delhi Post 15 October 2021 https://delhipostnews.com/transforming-cities-story-of-two-roads-in-delhi/
Sara Varughese
Delhi Chief Minister Arvind Kejriwal’s advertisement says, “How will Delhi’s streets become like those of Europe.†This was a full-page advertisement by the Delhi government for a workshop on transforming Delhi’s streets. The advertisement had a background picture of the newly renovated Chandni Chowk. With brutal honesty and reality, in the foreground of the picture lay an adult helping his child to ease hi Read More... -
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Delhi Post http://t.ly/o0Ya
Sara Varughese
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Indian Pediatr. 1981 Jul;18(7):443-8.
: Puliyel JM, Agrawal RK, Chansoria M.
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Indian J Pediatr. 1982 Sep-Oct;49(400):671-9.
Agrawal RK, Puliyel JM, Chansoria M, Mukerjee B, Kaul KK.
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Indian Pediatr. 1983 Nov;20(11):865-7.
Puliyel JM, Thomas PG.
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Indian Pediatr. 1984 Mar;21(3):251-2.
Puliyel JM, Kumar M.
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Indian Pediatr. 1984 Mar;21(3):258.
Puliyel J
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BMJ 1987;295:1419
Varughese S, Puliyel M, Puliyel J
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Indian Pediatrics 1985;22:249
Puliyel JM
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Aust Paediatr J. 1986 May;22(2):139-41.
Puliyel JM, Komaranchath A, Kumar KR.
Cushing's syndrome, a characteristic pattern of obesity with hypertension due to the hyperfunction of the adrenal cortex, is relatively rare in infancy. Thirty-six infants have been reported in world literature, most of whom have had adrenal tumours. There are only eight reported cases of infants under the age of 1 year with adrenal hyperplasia responsible for Cushing's syndrome. This is a report of an 8 month old child with bilateral nodular adrenal hyperplasia.
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Br J Dermatol. 1986 Aug;115(2):243-8.
Puliyel JM, Sridharan Iyer KS.
A family with a symptom complex of pes planus, onychogryphosis, palmoplantar hyperkeratosis and periodontosis is reported. A detailed pedigree is given and the mode of inheritance is suggested
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Indian Pediatr. 1987 Aug;24(8):690.
Puliyel JM
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Trop Geogr Med. 1987 Oct;39(4):385-7
Puliyel JM, Daniel A, Mathew CH.
A case of the Ellis-van Creveld syndrome is described. Emphasis is laid on the probable relation to the frequency of consanguineous marriages among the Hindu community in Kerala.
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J of Tropical Pediatrics 1988;34:201
Khare M, Shivastava DK, Puliyel J.
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Indian Pediatr. 1988 Apr;25(4):384-6.
Varughese S, Kumar A, Rao S, Puliyel JM.
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Indian Pediatr. 1989 Oct;26(10):1062-3.
Puliyel J, Nair LT.
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J Assoc Physicians India. 1990 Jun;38(6):444-5.
Varghese S, Vettath N, Iyer K, Puliyel JM, Puliyel MM.
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Ind Pediatr 1991;28:1083
Puliyel J
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Indian J Pediatr. 1992 Mar-Apr;59(2):197-202.
Khare M, Shrivastava DK, Puliyel JM.
The mid upper arm of 516 malnourished children (one to five years) were studied radiographically for changes in bone width, muscle mass and subcutaneous fat, of malnutrition at different ages. The data was studied by statistical analysis, determining the correlation coefficients of each of the factors. The findings indicate that previous assumptions about the components and the changes of the mid upper arm girth (MUG) in chronic severe malnutrition, were perhaps too simplistic.
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Clin Genet. 1992 Mar;41(3):139-42.
Puliyel JM, Puliyel MM, Varughese S.
The trichorhinophalangeal syndrome associated with laxity of the skin and joints has been mistaken for Ehlers-Danlos syndrome (Jones 1988). We report a case of the trichorhinophalangeal syndrome which we mistook for the Larsen syndrome. Literature and published photographs of the Larsen syndrome are reviewed to highlight the similarities between these two entities. These observations may be of value in the genetic mapping of the Larsen syndrome, which perhaps is a contiguous gene syndrome.
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BMJ. 1994 Jul 30;309(6950):338-9.
Puliyel J
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Conference: Second European Pediatric Congress24-7 April 1996. Berlin Germany
Puliyel J, Puliyel M, Hincliff R.
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BMJ. 1996 Aug 31;313(7056):528-9.
Puliyel JM, Hughes A, Chiswick ML, Mughal MZ.
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Conference: Joint Meeting of International Symposium on Diabetes and Endocrine disorders of the young and 4th Asian Symposium of Childhood and Juvenile Diabetes: Chaing Mai Thailand Jan 26-9 1997
Puliyel J, Puliyel M, Hincliff R.
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Presented at the Joint Meeting of the International Symposium on Diabetes and Endocrine Disorders of the Young and the 4th Asian Symposium of Childhood and Juvenile Diabetes, Chaing Mai, Thailand, January 6-9, 1997.
Puliyel J, Puliyel M, Hincliff R.
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Indian Pediatr. 1998 Aug;35(8):791-5.
Puliyel JM.
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Indian Pediatr. 1998 Dec;35(12):1245-9.
Puliyel JM.
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BMJ 1999;319:188
Puliyel J
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Indian J Pediatr. 1999 Jul-Aug;66(4):621-5.
Singh SK, Sarin D, Puliyel JM, Srivastav R, Gupta R, Kumar N, Mathews A.
An 11 year old male presented with headache, vomiting and weakness of right side of body. One day after admission he developed right focal seizures. He had 5 previous episodes of stroke, the first at 11 months age. His milestones were normal upto the first episode but subsequent mile stones were delayed. His serum and CSF lactic acids were raised. Muscle biopsy showed ragged red fibres on modified Gomori-trichrome staining. His EEG, CT scan and MRI were normal this time. The child improved spont Read More... -
Ann Trop Paediatr. 1999 Dec;19(4):391-4.
Agarwal KS, Puliyel JM, Mathew A, Lahoti D, Gupta R.
Acute hepatitis A infection is an uncommon cause of pancreatitis in children. To date, only four cases have been reported in the paediatric literature. We report a 7-year-old girl with acute pancreatitis associated with hepatitis A infection who made a satisfactory recovery. The report highlights the CT findings including focal necrosis not previously reported. Because of the extreme rarity of the complication, the four previous reports have also been single case reports. This paper reviews all these cases with a view to elucidating the aetiopathogenesis of the pancreatitis.
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Indian Pediatr. 2000 Jan;37(1):107-10.
Puliyel J
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Indian Pediatr. 2000 Feb;37(2):203-5.
Agarwal KS, Beri RS, Puliyel JM.
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J Trop Pediatr. 2000 Jun;46(3):179-81.
Gupta S, Singh SK, Taneja V, Goulatia RK, Bhagat A, Puliyel JM.
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Resuscitation. 2000 Aug 1;45(3):221-4.
Agarwal KS, Puliyel JM.
The text book of Pediatric Advanced Life Support of the American Heart Association recommends that a reservoir is used with a self inflating bag valve device. The figure in the book suggests that if such a device is connected to an oxygen supply, the oxygen will fill the bag first and then go on to fill the reservoir. However the valve structure of the self-inflating device does not permit active entry of oxygen into the bag, unless the bag is deflated and allowed to reinflate, drawing oxygen fr Read More... -
Indian Pediatrics 1999;36: 955-956
Angom Bisharda, Ruchie Chowdhury, Jacob M. Puliyel.
The detection of polymorphonuclear leukocytes in the CSF is a fairly reliable indicator of pyogenic meningitis but facilities required for its detection are not always available in rural hospitals in developing countries. To circumvent this problem Moosa et al.(1) tested the ability of urine dipsticks on CSF to help in the early diagnosis of pyogenic meningitis.
The urine dipstick leukocyte esterase test uses the ability of esterase enzyme present in the polymorphonuclear leucocytes to conv Read More... -
Indian Pediatr. 2000 Nov;37(11):1274-6.
Agarwal KS, Puliyel JM, Khanduri U.
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Archives of disease in childhood 2001;84:(Suppl 1) A43
Mughal Z, Agarwal K, Puliyel J, Upadhyaya P, Berry J, Mawer EB.
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Ind J of Pediatrics 2001;68:365
Abass F, Thomas RT, A Rajkumar, N Gupta, Puliyel J
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Am J Perinatol. 2001 Jun;18(4):217-24.
Gupta R, Thomas RD, Sreenivas V, Walter S, Puliyel JM.
An observational prospective study reported that newborn babies with Down syndrome (DS) had short upper limbs that reach up to their pelvis. The shortening was most marked in the forearm (the middle segment of the upper limb) and this relative shortening resulted in an alteration of the proximal to middle segment length ratio. This study assumes that there is a similar alteration in the ratio of the lower limb. We propose to study the proximal to middle segment ratio in the lower limb in normal Read More... -
Indian Pediatr. 2001 Jul;38(7):714-9.
Singhal D, Kumar N, Puliyel JM, Singh SK, Sreenivas V.
OBJECTIVE: Prediction of mortality by application of Pediatric Risk of Mortality (PRISM) score in Pediatric Intensive Care Unit (PICU) patients under Indian circumstances. DESIGN: Prospective study. SETTING: PICU of a tertiary care multi-specialty hospital. METHODS: 100 sick pediatric patients admitted consecutively in PICU were taken for this study. PRISM score was calculated. Hospital outcome was recorded as (died/survived). The predicted death was calculated by the formula: RESULTS: Of 100 pa Read More... -
Puliyel JM, Miller M, Alan Maynard
Mark Miller, CDC Atlanta, WHO
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Indian J Ophthalmol. 2001 Sep;49(3):187-8.
Varughese S, Jain S, Gupta N, Singh S, Tyagi V, Puliyel JM.
Neonates Delhi St Stephens Hospital. This report describes the extent and severity of retinopathy of prematurity (ROP) in a large maternity unit. The screening of 79 preterm babies showed that ophthalmic examinations should become an important part of neonatal care.
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Vaccine. 2001 Sep 14;19(32):4592-4.
Puliyel JM, Agarwal KS, Abed Abass F.
Puliyel JM, Agarwal KS, Abed Abass F.
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Indian Pediatr. 2001 Nov;38(11):1281-6.
Srivastava RK, Gupta S, Bhargava M, Kumar N, Upadhyay P, Puliyel JM.
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Child: Care Health & Development 2002; 28:95-100
Taneja V, Sriram S, Beri RS, Sreenivas V, Aggarwal R, Kaur S, Puliyel JM.
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BMJ. 2002 Jan 12;324(7329):112.
Sachdev P, Bahl S, Puliyel JM.
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Ann Trop Paediatr. 2002 Mar;22(1):109-10.
Agarwal K, Thomas N, Taneja V, Beri RS, Khanduri U, Puliyel JM.
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BMJ. 2002 Apr 20;324(7343):975.
Ojha RK, Abraham J, Khosla M, Puliyel JM.
No abstract Global alliance on vaccines and immunizations.
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Pediatrics. 2002 Jul;110(1 Pt 1):193.
Puliyel J
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Arch Dis Child. 2002 Aug;87(2):111-3.
Agarwal KS, Mughal MZ, Upadhyay P, Berry JL, Mawer EB, Puliyel JM.
AIMS: To compare the vitamin D status of 34 children, 9-24 months old, living in an area of Delhi renowned for high levels of atmospheric pollution (Mori Gate), with a comparable age matched group of children from a less polluted (Gurgaon) area of the city. METHODS: Serum concentrations of calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH), 25-hydroxyvitamin D (25(OH)D), and 1,25-dihydroxyvitamin D (1,25(OH)2D) were measured. Haze scores, regarded as a surrogate marker of solar UVB r Read More... -
J Trop Pediatr . 2002 Oct;48(5):315-6.
Anupam Sehgal, Sangita Gupta, Vineet Tyagi, Shubhra Bahl, Saroj K Singh, Jacob M Puliyel
RESEARCH LETTERS
Journal of Tropical Pediatrics Vol. 48 October 2002 315
FIG. 1. Distribution of gallbladder wall edema in children with a fever of 101ºF for 5 days or more.
Gall Bladder Wall Edema is Not Pathogenic of
Dengue Infection
We have previously reported gall bladder wall
edema (GBWE) in serology-proven pediatric
dengue hemorrhagic fever (DHF).1 Contemporane-
ously, Setiwan, et al.2 reported GBWE in 94 out of
148 serologically-proven dengue cases. However is
GBWE pathogno Read More... -
Indian J Pediatr. 2002 Nov;69(11):957-60.
Khanna R, Taneja V, Singh SK, Kumar N, Sreenivas V, Puliyel JM.
OBJECTIVE: To assess the usefulness of clinical risk index of babies (CRIB score) in predicting neonatal mortality in extremely preterm neonates, compared to birth weight and gestation. METHODS: 97 preterm neonates with gestational age less than 31 weeks or birth weight less than or equal to 1500 g were enrolled for the prospective longitudinal study. Relevant neonatal data was recorded. Blood gas analysis results and the maximum and the minimum FiO2 required by babies in first 12 hours of life Read More... -
Health Policy Plan. 2002 Dec;17(4):420-4.
Choudhary R, Sharma A, Agarwal KS, Kumar A, Sreenivas V, Puliyel JM.
NTRODUCTION: Interventions on behalf of the marginalized in society can assume many formats. In an urban slum the Government of Delhi built one-room houses for some of the residents in what is termed a 'plot area'. Not all residents could be accommodated in the project and the remainder continued to live next door in shanty houses of the slum. Nineteen years later, young children who had migrated with their parents, have grown up and have children of their own. We looked at the develop Read More... -
Indian J Pediatr. 2003 Jan;70(1):97-100.
Abass FA, Shahi M, Kumar N, Bhargava M, Gupta S, Puliyel JM.
A-10-year-old child admitted with repeated seizures due to the long QT syndrome is described. The cardiac origin of the epilepsy was suggested by the fact that during the episode of convulsions his peripheral pulses were not palpable.
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Pharmacoeconomics. 2003;21(7):497-9.
Tyagi V, Singh SK, Sawhney A, Taneja V, Puliyel JM.
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Indian J Pediatr. 2003 Feb;70(2):188.
Puliyel JM, Mittal R, Tyagi V, Gupta S.
Kane M, Miller MA.
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Indian Pediatr. 2003 Mar;40(3):204-10
Kumar N, Thomas N, Singhal D, Puliyel JM, Sreenivas V.
Sick score, sick calculator.
OBJECTIVE: To evolve a triage scoring system for severity of illness based on clinical variables related to systemic inflammatory response syndrome (SIRS). DESIGN: Prospective study in a tertiary-care hospital. METHODS: Consecutive pediatric patients admitted to the ward or pediatric intensive care unit (PICU) were studied. The respiratory rate, heart rate, capillary refill time, oxygen saturation (SpO2), systolic blood pressure and temperature were noted, Sensorium Read More... -
Arch Dis Child. 2003 Apr;88(4):366.
Puliyel JM, Bhambhani V.
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Med Sci Monit. 2003 Apr;9(4):BR130-3.
Puliyel JM.
BACKGROUND: Rapid drops in blood glucose and sodium levels during treatment of diabetic ketoacidosis (DKA) can cause a drop in the osmotonicity of plasma, resulting in cerebral edema. Ketone bodies are assumed to move freely in and out of cells, so it is assumed that they do not contribute to the tonicity of plasma or influence fluid shifts. The assumption that ketone bodies do not contribute to osmotonicity has not been tested previously. The experiment described here was done to check if aceto Read More... -
Jacob Puliyel
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J Hepatol. 2003 Jul;39(1):133; author reply 134-5.
Tiwari L, Varghese RM, Puliyel JM.
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BMJ. 2003 Jul 19;327(7407):126
Khanna R, Kumar A, Vaghela JF, Sreenivas V, Puliyel JM.
OBJECTIVE: To determine whether the imbalance in the sex ratio in India can be explained by less favourable treatment of girls in infancy. DESIGN: Analysis of results of verbal autopsy reports over a five year period. SETTING: Community health project in urban India. MAIN OUTCOME MEASURES: Deaths from all causes in infants aged less than 1 year. RESULTS: The sex ratio at birth was 869 females per 1000 males. The mean infant mortality was 1.3 times higher in females than in males (72 v 55 per 100 Read More... -
Recent Advances in Pediatrics 13. Editor Suraj Gupte. Publisher Jaypee Brothers New Delhi Page 261-6
Puliyel JM, Anish James Thomas, Kapil Jindal.
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Lancet. 2003 Dec 20;362(9401):2119; author reply 2119-20.
Sahni M, Varghese RM, Puliyel JM.
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J Postgrad Med 2004;50:178-179
Rai S, Puliyel JM
Loss of hearing, very early in life, can affect the development of speech and language, social and emotional development, and influence behaviour and academic achievement.[1] The critical or sensitive period for the acquisition of language extends from 1 to 5 years of age. However, impairment of hearing commencing after 5 years of age can also have serious consequences. Ninety-five per cent of school children suffer from middle-ear disease, sometime in the first 10 years of their life.[2] Otorrh Read More... -
Indian Journal of Gastroenterology , Year 2004, Volume 23, Issue 4 154-156
Varghese R Mathew, Abraham Jacob, James Jyotsna, Puliyel Jacob M
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Rapid response in ebmj to BMJ 2004; 329: 1051
Jacob M. Puliyel, Noopur Baijal, Dherain Narula.
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Indian J Gastroenterol. 2004 Jan-Feb;23(1):16-8
Sahni M, Jindal K, Abraham N, Aruldas K, Puliyel J.M
Hepatitis B immunization: cost calculation in a community-based study in India. (REPLY)Keyords:
BACKGROUND AND AIM: In India, approximately 65% of mothers deliver at home, and a community-based study evaluating the cost of vaccinating newborns with the first dose of hepatitis B vaccine within 48 hours has not been undertaken previously. This policy planning study was done to evaluate the costs of such immunization in India. METHODS: All mothers delivering in the study area (population 65,000) o Read More... -
Lancet. 2004 Feb 21;363(9409):659.
Puliyel JM.
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Pediascene Mar-June 2004
Puliyel JM.
‘IAP Policies, Guidelines and Recommendations on
Immunization 2003’
Citing the Evidence
-
Pediascene March - June 2004 Pg 16 www.pediascene.com
Baijal N, Puliyel JM.
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Indian J Pediatr. 2004 Apr;71(4):297-9.
Taneja V, Beri RS, Puliyel JM.
OBJECTIVES: This paper attempts to validate the programme of structured play lasting 90 minutes a day, for use in orphanages, to check if it can be replicated in other orphanages, with similar results. METHODS: A 2-week workshop on the structured play scheme was conducted at the Missionaries of Charity Orphanage in Delhi, the venue of the original project. 15 MOC sisters from 6 centers attended the workshop. The authors selected the MOC orphanage at Chandigarh to track the benefits of the progra Read More... -
http://www.bmj.com/cgi/eletters/328/7440/597#58014
Puliyel J
I have been following the discussion on academic medicine, and have been impressed by your global approach. Thus you seem, not to be attempting to revitalize academic medicine in the UK but internationally, and such an approach is most likely to promote the science and health in general.
In India research is an essential component of post-graduate training. For the MD, or MS and the DNB (Diplomate of the National Board) it is mandatory to submit a research dissertation or thesis, besides app Read More... -
Lancet. 2004 Jul 17-23;364(9430):245-6.
Narula D, Tiwari L, Puliyel JM.
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BMJ. 2004 Oct 30;329(7473):1043
Tiwari L, Puliyel JM, Upadhyay P.
Surfactant, Cochrane meta-analysis
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Indian Pediatr. 2004 Oct;41(10):1076-7.
Tiwari L, Puliyel JM.
Sundernagri
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Health Econ. 2004 Nov;13(11):1147; author reply 1147-8.
Puliyel JM.
Mark Miller, Call for retraction of paper, Exaggeration of deaths caused by Hepatitis B in India
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http://books.google.com/books?hl=en&lr=&id=Z222-Oul_VgC&oi=fnd&pg=PA117&ots=8ZpQ4Bra5p&sig=ExPzsrXM1EOVFl5509wLvi9smkM#PPA117,M1 In Focus on Meningitis Research. Editor Phyllis V. Strong Chapter 7, Nova Biomedical Books New York 2004. Pg 117-129.
Samridh Nagar, Jacob M. Puliyel
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The Telegraph
G.S.Mudur
Miller Call for retraction in Health Economics
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http://www.bmj.com/cgi/eletters/329/7474/1059#87378
S. Hydros, V Sreenivas Puliyel J
Nicholas J Beeching has succinctly summarized the situation with regards hepatitis B in the UK (1). It is however unclear how he arrived at the conclusion that universal immunization should be preferred in Britain. We have serious concerns about this. An assessment of the data provided, shows an unfavourable cost: benefit ratio. The annotation has drawn heavily on one reference (2). In this paper we will also rely on the same source for most of our calculations, so it is not just a matter of us Read More... -
Ann Trop Paediatr. 2004 Dec;24(4):361-3.
Tiwari L, James J, Chowdhary S, Sharma A, Puliyel JM.
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Indian J Pediatr. 2004 Dec;71(12):1141;
Sathyamala C, Puliyel JM.
If the polio eradication program fails, oral polio vaccine will be withdrawn from the market. User fee will be introduced for the injectable polio vaccine. The poor will be unprotected and then we will have a catastrophic epidemic.
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Ann Pharmacother. 2005 Jan;39(1):198-9.
Bhambhani V, Kumar N, Puliyel JM.
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Evidence-Based Medicine 2005;10:130; doi:10.1136/ebm.10.5.130-a
Jacob M Puliyel, MRCP, MPHIL, MD1 and Vishnubhatla Sreenivas, PhD2
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Expert Rev. Pharmacoeconomics Outcomes Res.2005;5:515-6
Arora R, Puliyel JM.
“Suppose it were ascertained that every child in the world could be rendered absolutely immune from all disease during its entire life by taking half an ounce of radium to every pint of its milk. The world would be none the healthier, because not even a Crown Prince - no, not even the son of a Chicago Meat King, could afford the treatment. Yet it is doubtful whether doctors would refrain from prescribing it on that ground. The recklessness with which they now recommend wintering in Egypt o Read More... -
Med Sci Monit. 2005 May;11(5):CR235-240. Epub 2005 Apr 28.
Sawhney A, Kumar N, Sreenivas V, Gupta S, Tyagi V, Puliyel JM.
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Curr Eye Res. 2005 Jun;30(6):423-8.
Varughese S, Varghese RM, Gupta N, Ojha R, Sreenivas V, Puliyel JM.
PURPOSE: The refractive status of premature infants is not well studied. This study was done to find the norms of refractive error in newborns at different gestational ages. METHODS: One thousand two hundred three (1203) eyes were examined for refractive error by streak retinoscopy within the first week of life between June 2001 and September 2002. Tropicamide eye drops (0.8%) with phenylephrine 0.5% were used to achieve cycloplegia and mydriasis. The refractive error was measured in the vertica Read More... -
Arch Dis Child Fetal Neonatal Ed. 2005 Sep;90(5):F444-5.
Bhambhani V, Beri RS, Puliyel JM.
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Crit Care Med. 2005 Oct;33(10):2448; author reply 2448-9.
Sawhney A, Puliyel JM.
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NBE Bulletin Volume 1 Number 3 Oct-December, 2005 Page 4
Jacob Puliyel
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The News of the National Board of Examination Volume 1 Number 3 Oct-December, 2005 Page 4. http://www.natboard.edu.in/news_latters/NBE%20BulletinVol.I%20No.3,%20October-Dec%202005.pdf
Puliyel J
http://www.natboard.edu.in/news_latters/NBE%20BulletinVol.I%20No.3,%20October-Dec%202005.pdf
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Sunday Magazine The Hindu 30/10/05
Puliyel J
Erb's Palsy, Rubella vaccine, Nocturnal enuresis, Primary complex, Hair on the upper lip in girls, Eating problems
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Child: Care, Health and Development Volume 31 Page 703 - 6. November 2005
V. Taneja, R. Aggarwal, R. S. Beri and J. M. Puliyel
BACKGROUND: We have previously reported the developmental gains achieved, after introducing a simple programme of structured play to stimulate children in an orphanage. It was envisaged that the caregivers could continue the programme. However, the enthusiasm of the caregivers waned over the year the programme was entrusted to them. After 1 year, a full time play therapist was recruited to rejuvenate the play programme. METHODS: Children's development was assessed using the Indian adaptatio Read More... -
* Ann Pharmacother. 2005 Dec;39(12):2140; author reply 2140-1.
Bhambhani V, Kumar N, Puliyel JM.
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Ashish Batham, Dherian Narula, Tanmay Toteja, V Sreenivas and Jacob M Puliyel
Meeting of Experts on Draft White Paper presented by Jacob Puliyel. Systematic Review and Meta analysis
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J Pediatrics and Child Health. 2006;42: A8
Baijal N, Puliyel J, Beri R, Sreenivas V.
Royal Australasian College of Physicians.
Pediatrics and Child Health Division Annual Conference Queensland 2006
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Arch Dis Child. 2006 Jan;91(1):51.
Chakrabarty A, Hydros S, Puliyel JM.
See last page 51
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BMJ 2006;333:621, doi:10.1136/bmj.333.7569.621-c
Ganapati Mudur
Indian Medical Association report on Hepatitis B
Indian association questions plan for hepatitis B immunisation
New Delhi
Ganapati Mudur
The Indian Medical Association has criticised a government proposal to expand universal
immunisation against the hepatitis B virus throughout India, saying that it would be “wasteful
spending” on a low priority health problem.
In a report sent to the health ministry, the association said that a systematic review of
studies indicates that th Read More... -
Medical Varitas 2006;3: Proof pages
Tiwari L, Baijal N, Kumar N, Puliyel JM
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J Postgrad Med. 2006 Apr-Jun;52(2):102-5.
Bhal S, Tygai V, Kumar N, Sreenivas V, Puliyel JM
Triage score Sick score calculator.
BACKGROUND: Signs of Inflammation in Children that can Kill (SICK score) is a new severity-of-illness score. It uses the physical signs of the Systemic Inflammatory Response Syndrome (SIRS) and its continuum - the Multiple Organ Dysfunction Syndrome (MODS). The development of the score used multiple logistic regression model coefficients converted to integer scores that have been published earlier. AIMS: The present study was done to validate the scoring syst Read More... -
BMC Pediatr. 2006 Apr 20;6(1):13
Ojha RK, Singh SK, Batra S, Sreenivas V, Puliyel JM.
ABSTRACT: BACKGROUND: ACOG states meconium stained amniotic fluid (MSAF) as one of the historical indicators of perinatal asphyxia. Thick meconium along with other indicators is used to identify babies with severe intrapartum asphyxia. Lactate creatinine ratio (L: C ratio) of 0.64 or higher in first passed urine of babies suffering severe intrapartum asphyxia has been shown to predict Hypoxic Ischaemic Encephalopathy (HIE). Literature review shows that meconium is passed in distress and thin mec Read More... -
http://www.bmj.com/cgi/eletters/338/apr06_2/b1423#214238
Jacob M. Puliyel, Himanshu Aneja, Sona Chowdhary.
By happenstance, the week after the BMJ �Short cuts� (1) summarized the paper by Sankaranarayanan et al that HPV testing can reduce cervical- cancer mortality (RR 0.52) (2) the Lancet published its editorial on harms from screening (3). However none of the many reviews of the study on �HPV- testing� questioned the wisdom of author�s suggestion that screening for HPV would be an efficient way to reduce cervical cancer. We hope our letter wil Read More... -
2/4/06 Sunday Magazine The Hindu
Puliyel J
Tourette Syndrome, Asthma, Constipation
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http://www.bmj.com/cgi/eletters/332/7545/804#131729
Puliyel J, Amit Kumar
Universal vaccination of all in the UK with Hepatitis B vaccine will reduce the yearly incidence of new cases of chronic carriers by a mere 4%. 96% of the burden of disease results from disease in immigrants who will not be helped by universal immunisation in the UK. Although these stark facts are widely known (1), in the space of a little more than a year, we have had two editorials in the BMJ, (authored by individuals with declared conflict of interests) suggesting that the UK government must Read More... -
Indian Pediatr. 2006 May;43(5):456-7
Rangasami JJ, Puliyel J.
West Middleswx University Hospital London
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BMC Pediatr. 2006 May 6;6(1):14
James J, Tiwari L, Upadhyay PK, Sreenivas V, Bhambhani V, Puliyel J.
ABSTRACT: BACKGROUND: The hard edges of adult finger clip probes of the pulse oximetry oxygen saturation (POOS) monitor can cause skin damage if used for prolonged periods in a neonate. Covering the skin under the probe with Micropore surgical tape or a gauze piece might prevent such injury. The study was done to see if the protective covering would affect the accuracy of the readings. METHODS: POOS was studied in 50 full-term neonates in the first week of life. After obtaining consent from thei Read More... -
http://www.imanational.com/Hepatitis/Report.htm
Prof SK Mittal Dr Dharam Prakash, Dr Onkar Mittal, Dr C Sathyamala, Dr Jacob Puliyel, Dr T Gera Dr Joseph L Mathew
This is a brief report of the meeting of Experts held at Hotel Imperial on 14/5/06. The meeting was sponsored jointly by the IMA and PLAN international (India)
Indian Medical Association
Subcommittee on Immunization
Report on Hepatitis B and Poliomyelitis in India
Chairperson Professor S K Mittal
Indian Medical Association
New Delhi 2006
Contents
Section 1
Brief Report Read More... -
Recent Advances in Pediatrics 13. Jaypee Brothers New Delhi 2003. Editor Suraj Gupte Page 436 - 441
Puliyel J., Riju Mittal
Recent Adv Downs
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http://tinyurl.co.uk/0eyc accessed 9/7/06
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Allergy. 2006 Aug;61(8):1019-20.
Ratnaweera D, von Trilsbach J, Rangasami J, Green DA, Puliyel JM
Department of Paediatrics, West Middlesex University Hospital, Twickenham Road, Isleworth, Middlesex, UK.
A community-based study in the London Borough of Hounslow, which included patients in our District General Hospital (DGH) Paediatric Department, found that most families who had been prescribed adrenaline auto-injectors could not use them properly. This prompted the establishment of a new protocol for doctors and an Allergy Clinic where one nurse was responsible for training all patients. Read More... -
The Hindu 27/08/06
Puliyel J M
Asthma and Convulsions, Milk protein allergy, Nocturnal enuresis (Bed wetting), Growth hormone, Focal seizures.
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Trop Doct. 2006 Oct;36(4):216-7.
Green DA, Chowdhary S, Tiwari L, Lata S.
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http://www.imanational.com/Hepatitis/PositionPaper.htm
Prof SK Mittal Dr Dharam Prakash, Dr Onkar Mittal, Dr C Sathyamala, Dr Jacob Puliyel, Dr T Gera Dr Joseph L Mathew
Hepatitis B,
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http://www.hindu.com/mag/2006/11/19/stories/2006111900100400.htm The Hindu Magazine 19/11/06 Page 4
Jacob M Puliyel
IT is now being acknowledged that the National Polio Eradication Programme did not work according to plan. The failure of this magic bullet approach (repeated doses of oral polio vaccine) to solve what is essentially a water and sanitation problem was predictable. Yet, that did not mitigate the sadness its failure caused among many of us who have worked tirelessly to make it succeed. The Indian Medical Association (IMA) Sub-Committee on Immunisation debated on whether to go public with its find Read More... -
Indian Pediatrics 2007;44:11-14
Dhanasiri SK, Puliyel JM.
Editorial
Indian Pediatrics 2007; 44:11-14
Regulating Vaccines: Can Health-Economics Tools be used Profitably?
Direct-to-consumer vaccine advertisements are a recent phenomenon. In India a newborn can make up to 27 visits to the doctor for immunizations before his fifth birthday(1) (Table I). The vaccines cost approximately Rs 11,000. There is a built-in incentive for doctors to prescribe the vaccines.
After a market presence is established, in the next stage the equity argume Read More... -
BMC Pediatrics 2007, 7:2
Noopur Baijal* 1 , Mohit Sahni* 1 , Neeraj Verma* 1 , Amit Kumar* 1 , Nittin Parkhe* 2 and Jacob M Puliyel* 1
Case report
.
Discordant twins with the smaller baby appropriate for gestational age – unusual manifestation of superfoetation: A case report
Noopur Baijal* 1 , Mohit Sahni* 1 , Neeraj Verma* 1 , Amit Kumar* 1 , Nittin Parkhe* 2 and Jacob M Puliyel* 1
1Department of Pediatrics and Neonatology St Stephens Hospital, Tis Hazari, Delhi 110054, India
2Department of Radiology, St Stephens Hospital, Tis Hazari, Delhi 110054, India
BMC Pediatrics 2007, 7:2 doi:10.1186/1471-2431- Read More... -
Indian J Med Res 2007;125:1-4.
Puliyel JM, Gupta MA, Mathew JL
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Tropical Doctor 2007;37;59-60
Sara Varughese
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http://www.hindu.com/mag/2007/07/01/stories/2007070150200600.htm
Puliyel J
Asthma, inhaled steroids, Bronciolitis, Seroflo
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Indian Pediatrics 2007;44:663-74
Ashish Batham, Dherian Narula, Tanmay Toteja, V Sreenivas*, Jacob M Puliyel.
Abstract
Objective: To evaluate the point prevalence of Hepatitis B in India. Design: Meta-analysis of data on point prevalence from different parts of the country. Data sources: Searches were made in Medline, Cochrane Library and Best bets and previous reviews. A limited hand search of cross references was also done. Finally a consultation with experts was held to enlarge the references base. Review methods: Studies reporting prevalence of HBsAg were selected. Data from high risk groups were e Read More... -
Ind J of Med Res 2007; 125:696-8
Gupta MA, Puliyel J
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Indian Pediatrics 2007;44:596-7
Sreenivas V, Puliyel JM
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Hib initiative
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http://www.who.int/immunization/newsroom/Hib_vaccine/en/
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Lancet 2007;369:189
Amit Kumar, Puliyel JM
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Trop Doct. 2007 Jul;37(3):188-9.
Bhambhani V, Abraham J, Sahni M, Harit AK, Khare S, Puliyel JM.
We investigated an outbreak of Coxsackie B4 arthritis in a neonatal unit involving 20 neonates and 12 staff members, over an eight-month period. Laboratory investigations, serology tests, indicate that the outbreak was caused by Coxsackie B4 virus. Contamination of one of the overhead water reservoirs, supplying the nursery, was responsible. After the water tanks were cleaned out, no new cases were reported over five years.
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http://www.scidev.net/EditorLetters/index.cfm?fuseaction=readeditorletter&itemid=119&language=1
Jacob Puliyel
Research on Hib vaccine 'dubious'
*
Author: Jacob M Puliyel, M.D.
Affiliation:
Head of Paediatrics
St Stephens Hospital
Delhi, India
Date: 10 July 2007
I was quoted in the Hib vaccine news story from 4 July (see Hib vaccine could save thousands in Asia), but perhaps due to constraints of column space, I feel justice was not done to what I said.
My main argument against the research findings from Bangladesh is not that it does not make economic sense, but that the study Read More... -
Ind J Gastroentrology 2007;26:July 193-4
Toteja Tanmay, Satyamala C, Chowdhary Sona, Lata Suman, Puliyel Jacob
Point prevalence of hepatitis B in mother-child dyads in a stratified random sample in an urban resettlement community in Delhi
Toteja Tanmay1, Satyamala C2, Chowdhary Sona1, Lata Suman1, Puliyel Jacob1
1 Department of Pediatrics St Stephens Hospital, Delhi 110 054, India
2 Public Report on Health, Department of Social Welfare, 53 Lodhi Estates, New Delhi, India
Correspondence Address:
Puliyel Jacob
Department of Pediatrics St Stephens Hospital, Delhi 110 054
India
puliyel@vsnl.com
Read More... -
www.thelancet.com Vol 370 July 14, 2007 Pages 129-30
Jacob Puliyel, C Sathyamala, D Banerji.
Protective efficacy of a monovalent oral type 1 poliovirus vaccine
We the undersigned are shocked and dismayed that the Lancet should have published the paper on the protective efficacy of monovalent oral type 1 poliovirus vaccine by Grassly et al (April 21, p1356)1, having overlooked the serious ethical issues involved.
The article describes how the international oversight body on polio eradication recommended the rapid development licensing and introduction of a new monovalent type 1 ora Read More... -
Trop Doct. 2007 Oct;37(4):238-9.
Agarwal KS, Baijal N, Tiwari L, Verma N, Sahni M, Puliyel JM.
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J Pediatr. 2008 Jan;152(1):145-6;
Sema A, Puliyel JM.
Cerebral edema in diabetic ketoacidosis with serum sodium below 135 mEq/L
Hooran et al1 have studied a group of patients with diabetic ketoacidosis (DKA) and cerebral edema (CE) against 2 control groups without CE, one with and the other without hypernatraemia. They suggest that a gradual decrease in plasma glucose and a concomitant increase in serum sodium, decrease the likelihood of CE. This finding takes us a little closer to understanding CE in DKA.
However our analysis of their data s Read More... -
J Pediatr 2008 Jan;152(1):147-9
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Ind Pediatrics 2008;45:158-9
Rajib Dasgupta, Sanjay Chaturvedi,
Estimation of "True Incidence" of Polio: Some Methodological Issues
A recent report(1) has claimed that the true incidence of polio (due to wild polio virus) in India was 1625 in 2006 and not 674 as officially notified. The authors’ notions of "true incidence" and "misclassification" call for careful examination as they challenge the sensitivity of Acute Flaccid Paralysis (AFP) surveillance. Our methodological objections are as follows:
1. Computation Read More... -
Indian Pediatrics 2008; 45:158-159
Puliyel J, Sreenivas V.
Reply
1. We explicitly stated in our paper that we have assumed that the chance of one of the two stool samples being negative is independent of the result in the other while calculating the ‘false negatives’. Cases of polio may be misclassified as ‘non-polio AFP’ because culture techniques are not perfect, methods used for collection, storage and transport of stool samples are sub-optimal, and viral shedding is not continuous. The fact that the excretion of virus Read More... -
Indian Journal of Medical Research 2008;127:1-3
Puliyel JM, Madhavi Y
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Br. J. Ophthalmol.2008;92:879-882
S Varughese, C Gilbert, C Pieper, C Cook.
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Archives of Disease in Childhood 2008; 93 Suppl 1: A10 [paper].
Gupta MA, Sahni M, Puliyel JM, Rangasami J, Chakrabarti A, Halstead R*, Green DA, Puliyel A, Sreenivas V.
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Indian J Med Res. 2008;127:494-497
Jacob M. Puliyel, Pallav Rastogi & Joseph L. Mathew
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Indian Pediatr. 2008 Apr;45(4):312-4.
Kaur C, Sema A, Beri RS, Puliyel JM.
Indian Pediatrics 2008; 45:-312-314
A Simple Circuit to Deliver Bubbling CPAP
Charanjit Kaur, Akatoli Sema, Rajbir S Beri and Jacob M Puliyel
From the Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054, India.
Correspondence to: J M Puliyel, Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054, India. E-mail: puliyel@gmail.com
Manuscript received: June 4, 2007; Initial review completed: September 15, Read More... -
file:///C:/Documents%20and%20Settings/prem/Desktop/Ask.htm
Jacob M. Puliyel
Asthma, Seroflo under four, Poor eating, Slow child.
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BMJ, May 2008; 336: 974 - 975
Jacob M Puliyel and Ashutosh Shrivastava
Unmasking GAVI and Big Pharma: Rethinking Vaccine Access 9 April 2008
Previous Rapid Response Next Rapid Response Top
Jacob M. Puliyel,
Consultant Pediatrician and Head of Department
St Stephens Hospital, Tis Hazari, Delhi 110054 India.,
Ashutosh Shrivastava
Send response to journal:
Re: Unmasking GAVI and Big Pharma: Rethinking Vaccine Access
We are dismayed that the article �Rethinking global access to vaccines� has been published as an �Ana Read More... -
http://www.plosone.org/doi/pone.0002224. PLoS ONE 3(5): e2224. doi:10.1371/journal.pone.0002224.
Mohit Sahni, Neeraj Verma, D. Narula, Raji Mathew Varghese, V. Sreenivas, Jacob M. Puliyel
Introduction
Data from the census of 2001 suggests that there are only 933 women for every1000 men in India [1]. In 1992 Amartya Sen calculated that 37 million women were ‘missing’ in India [2]. The UN in 2001 estimated that there were 44 million missing women in India [3]. Societal bias favoring males is responsible for the situation [4]. This bias manifests as neglect of girls and women resulting in their early death [5], [6], [7], female infanticide [8], [9] and more recently, Read More... -
https://slideplayer.com/slide/11000094/
Charanjit Kaur, Akatoli Sema, Rajbir S. Beri and Jacob M. Puliyel
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Abstract sent 20th International Congress of Pediatrics Teheran
J Puliyel
1. The Enigma of Death in DKA
Death among children being treated for diabetic ketoacidosis (DKA) is something of an enigma: The deaths occur during treatment and has not declined in spite of the use of better human insulins and continuous infusions with accurate syringe pumps.
2. Overestimation of dehydration in DKA
At an annual meeting of the British Pediatric Association an elegant paper was presented that suggested that iatrogenic over-hydration was perhaps responsible.
The author Read More... -
Indian Pediatrics 2008;45:942-3
Kaur C, Puliyel J
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Bulletin of the World Health Organization | October 2008, 86 (10) doi: 10.2471/BLT.08.054692 . http://www.who.int/bulletin/volumes/86/10/08-056572.pdf
Sona Chowdhary & Jacob Puliyel
http://www.who.int/bulletin/volumes/86/10/08-056572.pdf
Incidence of pneumonia is not reduced by pneumococcal conjugate vaccine
Sona Chowdharya & Jacob Puliyela
a Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi 110054, India.
Correspondence to Jacob Puliyel (e-mail: puliyel@gmail.com).
Madhi et al.1 write that the pneumococcal conjugate vaccine (PCV) is an effective instrument for pneumonia prevention in children. This is not strictly true. WHO data2 suggest that Read More... -
http://www.ed.ac.uk/news/all-news/essay
Nirupa Puliyel
Nirupa Puliyel’s winning essay
When watching Braveheart last night with a group of international student friends we were surprised to find ourselves cheering when scenes featuring Edinburgh came on.
My French friend summarised it perfectly at the end of the movie. In what was a poor imitation of Mel Gibson’s accent (itself a poor imitation) she exclaimed: “Och aye! Makes you proud to be Scottish!â€
Edinburgh is truly Read More... -
Papers presented to Delhi High Court by the Government of India on Vaccine Petition of Dr KS Sexana et al
WHO experts
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Journal Indian Medical Association 2009;107:36-40
Mittal R, Varghese RM, Puliyel JM.
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INDIAN PEDIATRICS 2009; 46:184-5
Siddharth and Jacob Puliyel
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Indian J Med Res 2009;129: 205-207
Neeraj Gupta & Jacob Puliyel
Sir,
We congratulate the authors of this meticulous study1.
The authors found the incidence of Hib meningitis only
0.007 per cent and they speculate that the population may
have ‘natural immunity’ to invasive Hib disease.
This paper is published 10 years after the data
were obtained. Three years ago an editorial published
in the ‘Expert Review Pharmacoeconomics Outcomes
Research’, cited this study as an instance of selective
non-publication of research2. To under Read More... -
Indian J Med Res. 2009;129;339-340
Gupta N, Puliyel J.
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Lancet 2009;373:2195-6
Dabade G, Puliyel J.
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Vaccine. 2009;27:4247-51
Mathew JL
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Indian Pediatrics 2009:46;647
Aneja H, Puliyel J.
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Delhi High Court. (2009) Writ Petition (Civil) No. 13698 of 2009. Public Interest Litigation. Available at http://delhihighcourt.nic.in/index.html 2009
Prashant Bhushan Advocate, Petitioners: Saxena KB, Mittal SK, Banerji D, Imrana Qadeer, Kurien NJ, Priya R, Mira Shiva, Puliyel JM, Dabade G.
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. 13698 Of 2009
PUBLIC INTEREST LITIGATION
A WRIT PETITION IN PUBLIC INTEREST UNDER ARTICLE 226 OF THE CONSTITUTION OF INDIA HIGHLIGHTING HOW IRRATIONAL VACCINES ARE BEING ARBITRARILY INTRODUCED AND PROMOTED BY THE GOVERNMENT AT THE BEHEST OF VACCINE MANUFACTURERS AND OTHER VESTED INTERESTS.
Memo of Parties
IN THE MATTER OF:
DR. K. B. SAXENA (PH.D)
FORMER HEALTH SECRETARY, GOVERNME Read More... -
Indian Pediatr. 2009 Dec;46(12):1097-8.
Tiwari L, Baijal N, Puliyel JM.
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Ind J Pediatr 2009;76:1247-1257
Batham A, Gupta MA, Rastogi P, Garg S, Sreenivas V, Puliyel JM
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Petitioners on PIL by Professor K B Saxena. Filed by Prashant Bhushan
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. 13698 Of 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
REJOINDER AFFIDAVIT ON BEHALF OF THE PETITIONERS TO THE COUNTER-AFFIDAVIT OF RESPONDENT NO. 3 (ICMR)
I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephans Hospital, Tis Hazar Read More... -
http://www.plosmedicine.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2Ff75e65f0-2b4c-40f7-9c10-93f92d150b35&root=info%3Adoi%2F10.1371%2Fannotation%2Ff75e65f0-2b4c-40f7-9c10-93f92d150b35
Prashant Tyagi, Mira Shiva, Jacob Puliyel
Civil Society Activism Hinders Vaccine-introduction in India: Vote for autocracy?
Posted by Puliyel on 18 Mar 2010 at 11:18 GMT
Shearer and colleagues use sophisticated modeling techniques to try and explain why some countries take longer to adopt Haemophilus influenza type b (Hib) vaccine in their national immunization programs (1). A primary premise they make is that the vaccine is beneficial to society. Published evidence of strain shifts and side effects however contradict this ass Read More... -
Department of Pediatric St Stephens Hospital, Delhi
Pediatrics Protocols
Pediatric Handbook
3rd Edition
Department of Pediatrics and Neonatology
St Stephens Hospital
Tis Hazari
Delhi 110054
Preface
This protocol was prepared by Dr Neetu Vashisht, building on the work of previous editions and the work of Dr R S Beri, Dr Nirmal Kumar, Dr Vineet Tyagi and Dr Jyotsna James.
The First Edition was published in 2003 and the Second Edition in 2004. This third edition has been a long time coming.
The 3rd edition Read More... -
Indian Pediatrics 2010;47:342-5. http://indianpediatrics.net/apr2010/342.pdf
Kaur C, Chohan S, Khare S, Puliyel J.
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http://www.plosmedicine.org/annotation/listThread.action?inReplyTo=info%3Adoi%2F10.1371%2Fannotation%2F76eddb74-d498-4996-a22c-ac2e5a5f9ab8&root=info%3Adoi%2F10.1371%2Fannotation%2F76eddb74-d498-4996-a22c-ac2e5a5f9ab8
Jacob Puliyel
Demolishing democratic institutions to promote biotechnology
In our previous comment we had noted that the authors had found that democratic institutions retard introduction of vaccines. We had also written about how data from a local multi-center study was obtained through the ‘Right to Information Act’ (RTI) in India. This data showed the problem of Hib was much lower than what was being projected, to justify introduction of the vaccine in the national programme of immunization Read More... -
Clin Rheumatol. 2010 Apr 8
Saikia B, Aneja H, Jain J, Puliyel JM.
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Indian J Med Res 2010;131:588-9
Puliyel JM, Mathew JL, Priya R.
Incomplete reporting of research in press releases: Et tu, WHO?
Jacob Puliyel
Head of Department of Pediatrics, St Stephens Hospital, Delhi, India
JL Mathew
Assistant Professor of Pediatrics, Advanced Pediatrics Centre, PGIMER, Chandigarh, India
Ritu Priya
Associate Professor Centre of Social Medicine and Community Health
Jawaharlal Nehru University, New Delhi, India
Address for correspondence
Jacob Puliyel
St Stephens Hospital
Tis Hazari, Delhi. 110054 India
puliy Read More... -
http://www.bmj.com/cgi/eletters/340/apr20_2/c2004#234904
Puliyel J
Lee and Harmer have highlighted the achievements of GAVI but they have also cited the criticisms leveled against it (1). Their article however would have gone to press before the recent controversy over WHO and GAVI functioning, started in India.
This week, the Indian Journal of Medical Research published an article entitled: "Incomplete reporting of research in press releases: Et tu, WHO" (2). The article relates to a press release issued by WHO jointly with GAVI, USAID, and Johns Read More... -
Ital J Pediatr. 2010 Apr 26;36(1):35. [Epub ahead of print]
Gupta MA, Chakrabarty A, Halstead R, Sahni M, Rangasami J, Puliyel A, Sreenivas V, Green DA, Puliyel JM.
To validate the SICK scoring system's ability to differentiate between individuals with higher and lower probabilities of death
Method
We performed a one year two-centre prospective evaluation of all children aged between one month and 12 years referred to the Paediatric team at St Stephens Hospital in Delhi and admitted to the Paediatric Department at West Middlesex University Hospital in London. We calculated SICK scores at presentation and correlated them with subsequent in-hospital Read More... -
Indian J Med Res 2010;131: 617-628
Y. Madhavi, Jacob M. Puliyel, Joseph L. Mathew, N. Raghuram, Anant Phadke, Mira Shiva, S. Srinivasan, Yash Paul, R.N. Srivastava, A. Parthasarathy, Sunil Gupta, Udaykumar Ranga, V. Vijaya Lakshmi, Nayana Joshi, Indira Nath, C.M. Gulhati, Prabir Chatterjee, Anuradha Jain, Ritu Priya, Rajib Dasgupta, S. Sridhar, Gopal Dabade, K.M. Gopakumar, Dinesh Abrol, M.R. Santhosh, Sadhana Srivastava, S. Visalakshi, Anurag Bhargava, N.B. Sarojini, Devinder Sehgal, Sakthivel Selvaraj & D. Banerji
India has over a century old tradition of development and production of vaccines. The Government rightly adopted self-sufficiency in vaccine production and self-reliance in vaccine technology as its policy objectives in 1986. However, in the absence of a full-fledged vaccine policy, there have been concerns related to demand and supply, manufacture vs. import, role of public and private sectors, choice of vaccines, new and combination vaccines, universal vs. selective vaccination, routine immuni Read More... -
Ind Pediatrics 2010:47:542-3
Pompa Dutta and Jacob M Puliyel
We thank the NTAGI for publishing its
recommendation on Hib vaccine in Indian
Pediatrics(1) as this journal allows ‘extended peer review’ in its correspondence columns. We are concerned that the technical advisory body has overlooked crucial evidence gathered in studies done by the ICMR while making its recommendations.
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Indian J Med Res 132, July 2010, pp 1-3
Zubair Lone & Jacob M. Puliyel
The story of how pharmaceutical companies influenced scientists and official agencies like the World Health Organization (WHO) in the recent swine flu scare1 and the saga of the undeclared conflicts of interests of members of the WHO’s Strategic Advisory Group of Experts2 has set off alarm bells around the world. When trusted advisors are less than honest, the potential for harm is great, and the feeling of betrayal is poignant. A similar feeling of sadness and betrayal was evoked by the r Read More... -
http://www.bmj.com/cgi/eletters/340/jun29_4/c3508
Jacob Puliyel, KB Saxena, Debabar Banerji, Imrana Qadeer, NJ Kurian, Ritu Priya , Mira Shiva and Gopal Dabade.
Sri Lankan deaths following Pentavalent vaccine:
Acceptable collateral damage?
As a group of pediatricians, health care activists, teachers in Public Health and bureaucrats who have championed the cause of universal immunization in India all our working lives, we were taken aback at being described as ‘anti-vaccine’, in the print version of the BMJ (1). We plead for the right to respond in our defense, in the print version.
India is a country where 50% of the population, (mos Read More... -
BMJ 2010;341 c4001 Page 218
K B Saxena, Debabar Banerji, Imrana Qadeer, N J Kurian, Ritu Priya, Mira Shiva, Jacob Puliyel, and Gopal Dabade
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BMJ 2010;341:c4081 Pg 266
Jacob M Puliyel
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Indian J Med Res 2010;132: 230-233
Joseph L. Mathew, J. Puliyel
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Prashant Bhushan on behalf of petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. 13698 Of 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS
I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephans Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state Read More... -
Recent Advances in Pediatrics - Special Volume 21 Neonatology and Intensive Care, Editor Suraj Gupte, Japee Medical publishers Delhi 2011
Jacob M.Puliyel, Neeraj Gupta
-
Indian J Med Res 132, October 2010, pp 450-455
Response by J Puliyel and Z Lone to correspondence from T. Jacob John & Jayaprakash Muliyil
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Indian J Med Res 132, October 2010, pp 463-465
Responses By J Puliyel and Z Lone to Correspondence from Jacob John*, Anuradha Bose & Vinohar Balraj
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http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effective. Unedited version of Response to http://www.guardian.co.uk/lifeandstyle/2010/oct/11/vaccination-fears-developing-world-deaths.
Jacob M Puliyel
Published title:
India cannot afford to use vaccines that are not cost-effective.
Developing countries must spend their budgets wisely to save as many lives as possible.
http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effective
-
# The Guardian, Wednesday 27 October 2010. http://www.guardian.co.uk/commentisfree/2010/oct/27/india-vaccines-not-cost-effective
Jacob Puliyel
Unabridged version of the article is entitled
“If they don’t have bread let them take vaccines” - The contemporary Marie Antionette.
It is available at http://jacob.puliyel.com/#paper_224
-
http://www.rho.org/files/rb3/AEFI_Causality_Assessment_WHO_2005.pdf
https://brightoncollaboration.org/public/who-we-are/our-story.html
Page not found!
WHO Aide-Mémoire on AEFI causality assessment - http://www.who.int/vaccines-documents/DocsPDF05/815.pdf
Page not found
The WHO Has removed the Brighton Classification from it's web site it appears.
The classification is available still at
http://www.rho.org/files/rb3/AEFI_Causality_Assessment_WHO_2005.pdf
In case this page is removed it is available on this website
-
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Ann Pharmacother 2011;45:xxxx. Published Online, 28 Dec 2011, theannals.com, DOI 10.1345/aph.1P332
Aneet Patel, Shweta Mittal, Samiksha Manchanda, and Jacob Mammen Puliyel
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http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/bae6b668-a8fc-4b28-9964-bcac42a473dd&root=info:doi/10.1371/annotation/bae6b668-a8fc-4b28-9964-bcac42a473dd
Puliyel J
Response to
Glatman-Freedman A, Cohen M-L, Nichols KA, Porges RF, Saludes IR, et al. (2010) Factors Affecting the Introduction of New Vaccines to Poor Nations: A Comparative Study of the Haemophilus influenzae Type B and Hepatitis B Vaccines. PLoS ONE 5(11): e13802. doi:10.1371/journal.pone.0013802
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0013802
Response at
http://www.plosone.org/annotation/listThread.action?inReplyTo=info:doi/10.1371/annotation/bae6b668-a8fc-4b Read More... -
Br J Ophthalmol 2011;95:295e296. doi:10.1136/bjo.2010.188805. http://bjo.bmj.com/content/94/4/445/reply#bjophthalmol_el_9709
Ashish Puliyel, Jacob Puliyel
CUSUM for monitoring competency:
Computer software is useful for bootstrapping and real time CUSUM plotting.
We congratulate Salowi and colleagues on their study of the use of CUSUM to monitor competency in cataract extraction (1). However there are two modifications that could make their system more responsive and reliable.
Firstly the authors use a CUSUM chart that fluctuates on only one side of the zero line. Traditionally CUSUM charts fluctuate on both sides of the zero line (2,3). Read More... Indian Medical Association National Conference Jaipur 27 December 2010
Jacob Puliyel
http://www.youtube.com/watch?v=vGvu1sQfxAw
http://www.youtube.com/watch?v=elHP06rJvp8
http://www.youtube.com/watch?v=ib-Z9iPRI9s
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Economic & Political Weekly EPW april 2, 2011 vol xlvi no 14. Page 23-26 http://epw.in/epw/uploads/articles/15901.pdf
Jacob M. Puliyel
Evidence Based Medicine: Making It Better
Jacob M Puliyel MD MPhil
Head of Pediatrics
St Stephens Hospital
Delhi 110054
Puliyel@gmail.com
Phone 09868035091
Abstract
Evidence Based Medicine (EBM) began as a 'bottom-up' paradigm that taught residents to search the literature for the best available evidence and to critically appraise it for making patient care decisions. As its popularity increased, there evolved a huge market for readymade EBM summaries and revi Read More... -
Prashant Bhushan on behalf of petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. 13698 Of 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS
I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen Head, Dept. of Pediatrics, St. Stephens Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state Read More... -
Word Text: Clinical Microbiology and Infection (CMI) and the International Journal of Antimicrobial Agents (IJAA), the official journals of ESCMID and ISC . (Abstract accepted for presentation 9/5/2011 and publication
J. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3) : 1 Department of Pediatrics St Stephens Hospital Delhi, 2 Department of Pediatrics Post Graduate Institute of Medical Science, (PGI) Chandigarh, 3 Department of Biostatistics All India Institute of Medical Science (AIIMS) Delhi
Numbers Needed to Treat (NNT) is a measure of the effectiveness. In the context of newer vaccines it is good to ask how many children need to be vaccinated so that one life is saved - the NNT of the vaccine. This is sometimes called the Numbers Needed to Vaccinate (NNV)
The next question is related to the cost: How much does it cost to vaccinate one child with this new vaccine.
Once we have these 2 figures we can easily calculate the cost per life saved.
We did a meta analysis (a study Read More... -
21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 27th International Congress of Chemotherapy (ICC) 07.05.2011 - 10.05.2011
J. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3) : 1 Department of Pediatrics St Stephens Hospital Delhi, 2 Department of Pediatrics Post Graduate Institute of Medical Science, (PGI) Chandigarh, 3 Department of Biostatistics All India Institute of Medical Science (AIIMS) Delhi
Numbers Needed to Treat (NNT) is a measure of the effectiveness. In the context of newer vaccines it is good to ask how many children need to be vaccinated so that one life is saved - the NNT of the vaccine. This is sometimes called the Numbers Needed to Vaccinate (NNV) The next question is related to the cost: How much does it cost to vaccinate one child with this new vaccine. Once we have these 2 figures we can easily calculate the cost per life saved. We did a meta analysis (a study of all th Read More... -
You have free access to this content Clinical Microbiology and InfectionVolume 17, Issue Supplement s4, Article first published online: 4 MAY 2011 http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2011.03558.x/pdf Page 299 P1442
J. Puliyel (1), J. Mathew (2), N. Vashisht (1), V. Sreenivas (3)
Effectiveness versus efficacy of conjugated pneumococcal vaccine: a systematic review of randomised, controlled trials with meta-analysis examining absolute risk reduction and relative risk
Objectives: Use of the 7-valent pneumococcal conjugate vaccine (PCV7) resulted in reduction in vaccine serotypes invasive pneumococcal disease (IPD). However, IPD due to serotypes not included in the PCV7 increased in frequency. This prompted the introduction of a 13 valent vaccine. Previous systematic rev Read More... -
Hum Vaccin. 2011 May 1;7(5). [Epub ahead of print]
Puliyel Jacob
Cost of pneumococcal vaccine
underestimated ten-fold
I commend Professor Light1 for his article on the pneumococcal AMC. His excellent article was however marred by a typographic error that overestimates the benefit from the vaccine at least ten-fold. I hope you will permit it to be corrected so the scientific record is accurate. The author quotes a paper by Madhi et al to suggest that 360 lives are saved per 100,000 vaccinated.2 This is a mistake. Madhi et al., in fact suggests only 360 &ldqu Read More... -
Indian J Med Res 133, May 2011, pp 560-563
Lone Z, Puliyel J
Sir,
We thank Gupta et al1 for responding to our editorial. Perhaps they have written the letter before the correspondences of Drs Madhavi & Raghuram2, Drs John & Muliyil3 and our response appeared in print.
All their questions have been answered in response to the letters above and we will be hard pressed to answer these questions without simply repeating ourselves.
The points they make are:
1. We should not have used under-2 morbidly statistics on the under 5 population.
Th Read More... -
PLoS ONE | www.plosone.org June 2011 | Volume 6 | Issue 6 | e20097 http://dx.plos.org/10.1371/journal.pone.0020097.
Samiksha Manchanda*, Bedangshu Saikia, Neeraj Gupta, Sona Chowdhary, Jacob M. Puliyel
Sex Ratio at Birth in India, Its Relation to Birth Order, Sex
of Previous Children and Use of Indigenous Medicine
Samiksha Manchanda*, Bedangshu Saikia, Neeraj Gupta, Sona Chowdhary, Jacob M. Puliyel
Department of Neonatology and Pediatrics, St Stephen Hospital, Delhi, India
Abstract
Objective: Sex-ratio at birth in families with previous girls is worse than those with a boy. Our aim was to prospectively
study in a large maternal and child unit sex-ratio against previous birth sex and use Read More... -
Am. J. Trop. Med. Hyg., 85(2), 2011, pp. 221–224 doi:10.4269/ajtmh.2011.11-0002
Archana Verma , Samiksha Manchanda , Nirmal Kumar , Archna Sharma , Masha Goel , Partha Sarathi Banerjee , Rajat Garg , Brahma Pal Singh , Fatima Balharbi , Veerle Lejon , Stijn Deborggraeve , Udai Veer Singh Rana , and Jacob Puliyel *
221
Am. J. Trop. Med. Hyg., 85(2), 2011, pp. 221–224
doi:10.4269/ajtmh.2011.11-0002
Copyright © 2011 by The American Society of Tropical Medicine and Hygiene
INTRODUCTION
Trypanosomes are flagellated protozoan parasites infecting
a wide range of animals and man. Human infection with
Trypanosoma brucei ( T.b.) gambiense or T.b. rhodesiense
causes African sleeping sickness (African trypanosomiasis)
and Trypanosoma cruzi causes Chagas disease (American trypanosomiasis).
These i Read More... -
Indian Pediatr. 2012;49:543-7
NEERAJ GUPTA, *ASHISH PULIYEL, AYUSH MANCHANDA AND JACOB PULIYEL
Nebulised Hypertonic-Saline against Epinephrine for Bronchiolitis: Proof-of-Concept Study by Cumulative Sum (CUSUM) Analysis
NEERAJ GUPTA, *ASHISH PULIYEL, AYUSH MANCHANDA AND JACOB PULIYEL
From the Department of Pediatrics and Neonatology, St Stephen�s Hospital, Delhi, India; and * Tech Guru gonzoBuzz, Singapore.
Correspondence to: Dr Neeraj Gupta, Registrar, Department of Pediatrics, St Stephen�s Hospital, Tis Hazari, Delhi 110 054, India. drnee Read More... -
G.O. (Rt) No 3678/2011H&FWD dated 20/10/2011
-
November 5, 2011 vol xlvI nos 44 & 45 EPW Economic & Political Weekly Pages 18-9
Jacob M. Puliyel
COMMENTARY
november 5, 2011 vol xlvI nos 44 & 45 EPW Economic & Political Weekly
18
Vaccine Policy and Advance Market Commitments
Jacob Puliyel
The new National Vaccine Policy Draft 2011 by the Union Ministry of Health and Family Welfare comes out openly in favour of public-private partnerships and suggests flexible governing and funding mechanisms to support vaccine development in the PPP mode. This article argues that our vaccine policy must look into the health of the children in Read More... -
Prashant Bhushan on behalf of the petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
C.M. No. OF 2011
IN
WRIT PETITION (CIVIL) No. 13698 OF 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
APPLICATION FOR DIRECTION ON BEHALF OF THE PETITIONERS UNDER SECTION 151 CPC
To,
The Hon’ble Chief Justice of Delhi And
His Hon’ble Com Read More... -
http://www.youtube.com/watch?v=AWE_L5-mGWE&feature=bf_prev&list=ULPIxogXq35bk&lf=mfu_in_order
Jacob Puliyel
Available on youtube at address in referenceIn acknowledgement of the world wide “Occupy Wall Street’ movement this talk is on ‘Occupy Medicine’
Specifically it is about vaccines for 99% versus profits for the 1%
There is the story of a sales person who went to a villager and asked to buy a donkey.
The villager said. I have a donkey. I need the money. You can have my donkey. It will cost $100.
The salesman paid the money and the villager promised to deliver the donke Read More... -
http://bit.ly/polio-afp
J. Puliyel, N.Vashisht, V. Sreenivas
The data on acute flaccid paralysis (AFP), polio and non-polio AFP and number of polio rounds in each state in each year from 2000 to 2009 were from the National Polio Surveillance web site (http://www.npspindia.org/bulletin.pdf).
a) Data on numbers of polio rounds during the year 2003 was incomplete.
b) When different areas within a state received different number of doses, the arithmetic mean number of doses was taken as the representative dose for that state.
2. Per capita income w Read More... -
Prashant Bhushan on behalf of the petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
C.M. No. 18416 of 2011
IN
Writ Petition (Civil) No. 13698 Of 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
BRIEF REJOINDER AFFIDAVIT ON BEHALF OF THE PETITIONERS TO THE AFFIDAVIT FILED BY THE UNION OF INDIA
I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen, Head, Dept. of Pediatrics, St. Step Read More... -
Chandrika 14 -20 April 2012. English version of Malayalam article
Jacob Puliyel
Of Micro-organisms and Men: Immunity and Vaccines
The best laid schemes of mice and men-
Often go awry
John Steinbeck. 1937
There are billions of micro-organisms in our environment. Some have a symbiotic relationship with us, meaning that the relationship between man and the micro-organism are mutually beneficial. Thus there are bacteria resident in our gut, that eats some of the food we have eaten, but in return they make useful vitamins for us to absorb and use. If we kill these harmless Read More... -
Indian Journal of Medical Ethics Vol IX No 2 April - June 2012 Page 114-7. http://www.issuesinmedicalethics.org/pdfs/202co114.html.pdf
Neetu Vashisht, Jacob Puliyel
TITLE: Polio programme: let us declare victory and move on
AUTHORS: Neetu Vashisht1, Jacob Puliyel1
AFFILIATION: Department of Paediatrics, St Stephens Hospital, Delhi 110054 INDIA Author for correspondence: Jacob Puliyel: e-mail
puliyel@gmail.com
Abstract
It was hoped that following polio eradication, immunization could be stopped. However the synthetesis of polio virus in 2002, made eradication impossible. It is argued that getting poor countries to expend their scarce resources on a Read More... -
Chandrika 14 -20 April 2012
Puliyel Jacob
Of Micro-organisms and Men: Immunity and Vaccines
The best laid schemes of mice and men-
Often go awry
John Steinbeck. 1937
There are billions of micro-organisms in our environment. Some have a symbiotic relationship with us, meaning that the relationship between man and the micro-organism are mutually beneficial. Thus there are bacteria resident in our gut, that eats some of the food we have eaten, but in return they make useful vitamins for us to absorb and use. If we kill these harmless Read More... -
Turkish Medical Association's journal Turkish Medical Association's journal ISSN 1300-4387 Community and Physician 2012 Volume 27 (1) Page 75-80
Puliyel Jacob
Introducing Pentavalent Vaccine in India:
How Public Interest Litigation Forced a Re-evaluation of the Evidence
The Istanbul Experience – Natural Immunity
In the year 2000 researchers from Turkey contradicted conventional wisdom about Haemophilus influenzae type b (Hib) infection when they suggested that infants in Istanbul had high concentrations of maternally transferred anti-polyribosylribitol phosphate antibodies (anti-PRP) and they acquired natural active immunity at an early Read More... -
Infectious Diseases in Clinical Practice: May 2012 - Volume 20 - Issue 3 - p 180–181
Sharma, Richa DCH; Parwal, Natwar DCH; Kumar, Nirmal MD; Puliyel, Jacob M. MD
Abstract
We report a newborn with congenital dengue infection and cardiomyopathy. Congenital dengue is known to occur owing to vertical transmission of the virus from an infected mother to her baby through the placenta. Dengue-related cardiomyopathy has been reported previously. This is arguably the first time cardiomyopathy is being reported in the context of congenital dengue. A systematic review of literature on congenital dengue as cited in Pubmed is also presented.
(C) 2012 Lippincott W Read More... -
Indian J Med Res 135, April 2012, pp 36-38
Ashutosh Shrivastava, Neeraj Gupta, Pramod Upadhyay & Jacob Puliyel
Background & objectives: Stabilized live attenuated oral polio vaccine (OPV) is used to immunize
children up to the age of five years to prevent poliomyelitis. It is strongly advised that the cold-chain
should be maintained until the vaccine is administered. It is assumed, that vaccine vial monitors (VVMs)
are reliable at all temperatures. VVMs are tested at 37°C and it is assumed that the labels reach discard
point before vaccine potency drops to >0.6 log10. This study was undert Read More... -
Economic & Political Weekly EPW may 26, 2012 vol xlviI no 21 Pages 43-54
C Sathyamala, N J Kurian, Anuradha De, K B Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Jacob Puliyel, Claire Noronha, Meera Samson
-
Journal of Clinical and Diagnostic Research. 2012 June, Vol-6(5): 863-866
Akatoli Sema, Rajeev Sethi, V K Bhatia, Jacob Puliyel
Radiological Appearance of Molars:
Do they consistently identify babies of 33-36 weeks gestation?
Akatoli Sema
Rajeev Sethi*
V K Bhatia**
Jacob Puliyel
Department of Pediatrics, St Stephens Hospital, Delhi
*Department of Radiology, St Stephens Hospital, Delhi
**Indian Agricultural Statistical Research Institute, Pusa Institute, Delhi
Running Title: Molar teeth and gestational age
Key Words: Ballard’s score, antenatal ultrasound age, bone age, tooth age, sma Read More... -
Writ Petition (Civil) No. 13698 of 2009 PUBLIC INTEREST LITIGATION
Prashant Bhushan on behalf of the petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. 13698 of 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. …PETITIONERS
VERSUS
UNION OF INDIA & ORS. …RESPONDENTS
SUPPLEMENTARY AFFIDAVIT ON BEHALF OF THE PETITIONERS
I, Dr. Jacob M Puliyel S/o Late Shri P. M. Mammen, Head, Dept. of Pediatrics, St. Stephens Hospital, Tis Hazari, New Delhi-110054, do hereby solemnly state and Read More... -
http://adc.bmj.com/search?fulltext=Identifying+Hypertension+using+Centile+Charts%3A+Overcoming+the+Problem+of+Blood+Pressure+Variability&resourcetype=HWELTR&submit=yes
Jacob Puliyel, Pediatrician Prabhjeet Kaur, Akanksha Jain, Zainab Golwala, Hardik Shah, Lokesh Tiwari
Identifying Hypertension using Centile Charts: Overcoming the Problem of Blood Pressure Variability
Jacob Puliyel, Pediatrician
Prabhjeet Kaur, Akanksha Jain, Zainab Golwala, Hardik Shah, Lokesh Tiwari
St Stephens Hospital Delhi
We commend Wu et al for their work on blood-pressure-ratios. Up until now hypertension was defined using statistically derived limits based on gender, age and height specific norms. The formulation of Wu et al permits assessments of adverse effects at d Read More... -
Journal of Clinical and Diagnostic Research. 2012 October, Vol-6(8): 1367-1368. DOI: 10.7860/JCDR/2012/4944.2389. http://www.jcdr.net/articles/pdf/2389/jcdr-6-1367.pdf
Jacob Puliyel
According to the amended Drugs and Cosmetics Rules of the Government of India, participants in clinical trial are entitled to medical treatment and financial compensation in the event of permanent injury or death, but the quantum of compensation is to be decided by same Ethics Committee that sanctioned the trial in the first place. If there is a dispute regarding the amount of compensation the injured party may appeal again to the Ethics Committee for a review and reconsideration. The decision o Read More... -
BMJ 2012;345:e7832 http://bmj.com/cgi/content/full/bmj.e7832?ijkey=zi5IcOwY7LAyzja&keytype=ref
Jacob Puliyel, Joseph L Mathew
Head to Head
Should India launch a national immunisation programme against rotavirus? No
BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e7832 (Published 30 November 2012)
Cite this as: BMJ 2012;345:e7832
Epidemiologic studies
Child health
Immunology (including allergy)
Neurogastroenterology
Infectious diseases
Article
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Jacob M Puliyel, consultant paediatrician1,
Joseph L Mathew, associate professor2
Au Read More... -
Govt of India
-
http://blogs.bmj.com/bmj/2012/12/20/jacob-puliyel-advertising-standards-and-vaccine-promotion/
Jacob Puliyel
Until last week few people in India had heard of the existence of the Advertising Standards Council of India (ASCI). Suddenly in the newspapers on the 15 December 2012 the ASCI was prominently featured. The story was about an advertisement for rotavirus vaccine on TV channels in many parts of the country. Set up in 1985 as a self regulatory voluntary organisation of the advertising industry, ASCI’s code in advertising is now part of the “advertisement code,” and its violation Read More... -
http://www.webmedcentral.com/wmcpdf/Article_WMC003904.pdf
Jacob Puliyel
Merchants and Mercenaries:
The Lost Maya Civilization
Between 1 December and 5 December in Cancun Mexico – the heart of Maya land, Zing Conferences organized the Mathematical and Computational Medicine Conference 2012. (1,2) In the spirit of the Christmas Issue of the WebMedCentral, it is appropriate that I write about the venue and the perspective it provided for a congress on Mathematical and Computational Medicine, that I do not discuss the computational problems in understanding the Read More... -
Indian Pediatrics 2012;49:989-991http://www.indianpediatrics.net/dec2012/989.pdf
BEDANGSHU SAIKIA, SUNAINA ARORA AND JACOB M PULIYEL
CASE REPORT
Pseudohypoparathyroidism with Diabetes Mellitus and Hypothyroidism
Bedangshu Saikia, Himanshu Aneja, Sunaina Arora, Jacob M Puliyel.
Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054, India.
CORRESPONDING AUTHOR:
Dr Bedangshu Saikia
Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054, India
Email: bedangshu@gmail.com
Ph: +919212770581
Fax: +91-11-23932412
KEYWORDS:
Albright's Hereditary Osteodystrophy (AHO), Pseudohypoparathyroidism Read More... -
http://blogs.bmj.com/bmj/2012/12/21/jacob-puliyel-on-the-pentavalent-study-in-kerala/
Jacob Puliyel
The 14 December 2012 marked the end of a year long pentavalent vaccine study in Kerala, India. Kerala is a small state in the south with some of the best healthcare indicators in the country. The pentavalent vaccine is to replace the diphtheria, pertussis, and tetanus (DPT) vaccine and combines H influenza B and Hepatitis B with the older trivalent vaccine.
The pentavalent vaccine study in neighboring Tamil Nadu has about a month more to run. The final results may take another three months to Read More... -
http://www.bmj.com/content/345/bmj.e7832?tab=responses
Jacob Puliyel, Joseph L Mathew
We thank Cunliffe and his co-authors from PATH and the Bill and Melinda Gates Foundation (B&MGF) for their response to our article. We note however, that they employ a straw-man fallacy to support rotavirus vaccine introduction globally.
Evidence from the Cochrane meta-analysis has demonstrated that rotavirus vaccine does not to reduce childhood mortality. (1) This makes it difficult to defend the promotion of this expensive vaccine in developing countries – being pushed as a &lsquo Read More... -
Writ Petition (Civil) No. 13698 of 2009 PUBLIC INTEREST LITIGATION
Prashant Bhushan on behalf of the petitioners
-
http://www.bmj.com/content/345/bmj.e7832/rr/622915
Joseph L. Mathew, Jacob Puliyel
Authors response 2. Re: Should India launch a national immunisation programme against rotavirus? No
3 January 2013
We thank Batik for responding to our paper on the rotavirus vaccines, and raising two distinct issues. The first relates to the efficacy of rotavirus vaccines. We would like to reiterate that the Cochrane review clearly shows that both RV1 and RV5 vaccines did not have any impact on mortality as compared to placebo, in WHO-defined low-mortality as well as high-mortality countries Read More... -
Professor BM Hegde, MD, PhD (Hon. Causa), FRCP (London), FRCP (Edinburgh), FRCP (Glasgow), FRCPI (Dublin), FACC, FAMS. Former Vice Chancellor, Manipal University, Manipal. Former Director-Professor and Dean, Kasturba Medical College, Mangalore. Visiting Professor of Cardiology, University of London between 1982 and 2005, Affiliate Professor of Human Health, University of Northern Colorado, USA. Vikas Bajpai PhD Centre for Social Medicine and Community Health, Jawaharlal Nehru University, Delhi Professor Amitav Banerjee Professor Community Medicine, Dr D Y Patil Medical College, Poona J P Dadhich MD Consultant Pediatrician, New Delhi. Arun Gupta MD FIAP Pediatrician, Member, Prime Minister's Council on India's Nutrition Challenges, Convener, Alliance Against Conflict of Interest(AACI) Professor K P Kushwaha Professor & Head of Pediatrics, BRD Medical College, Gorakhpur. UP. R Lodha Associate Professor, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi Professor S K Mittal Formerly Professor of Pediatrics, MAMC Delhi, Head of Pediatrics, Pushpanjali Crosslay Hospital, Delhi Professor Ritu Priya, Professor Centre of Social Medicine and Community Health Jawaharlal Nehru University New Delhi-110067 Jacob Puliyel MD MRCP M Phil Head of Pediatrics, St Stephens Hospital, Delhi Member National Technical Advisory Group on Immunization (NTAGI) Dhiraj Shah MD Reader in Pediatrics, University College of Medical Sciences, Delhi. Professor S Srinivasan MD Formerly Director-Professor of Pediatrics, JIPMER, Pondicherry
To
The Health Secretary
Ministry of Health and Family Welfare
Nirman Bhawan
New Delhi
January 15, 2013
Sir
Subject: Concern about deaths following Pentavalent Vaccine – making each death count.
We, a group of academicians, professors and teachers of public health and pediatrics, would like to draw your attention to the pattern of adverse events and deaths from the newly introduced Pentavalent vaccine (DPT+ Hib + Hep B).
Pentavalent vaccine was introduced in Kerala and Tamil N Read More... -
http://www.bmj.com/content/341/bmj.c4001/rr/629317
Jacob Puliyel
Author reply to response from Drs Phadke and Pramila
6 February 2013
Re: “Antivaccine Lobby” replies to the BMJ. K B Saxena, Debabar Banerji, Imrana Qadeer, N J Kurian, Ritu Priya, et al. 341:doi:10.1136/bmj.c4001
We thank the doctors Phadke and Pramila for their response to our article.
They raise 4 points which I will address individually
a) Disease burden in the population.
We have stated that the Minz study has found that the under five incidence of Hib meningitis Read More... -
http://www.bmj.com/content/341/bmj.c4001/rr/629565
Jacob Puliyel
We appreciate the comment by Dr Peter Flegg that deaths following immunization do not always imply a cause and effect relationship.
I know more about the deaths in India following Pentavalent vaccine and will base my response on that experience.
The autopsy reports suggest hypersensitivity reaction in many of the cases. There is no test that can be performed on the vials to look for the hypersensitivity reaction. We depend on the Brighton Classification of AEFI to confirm causation.
If Read More... -
http://www.bmj.com/content/341/bmj.c4001/rr/630682
Jacob Puliyel
Addendum to the response of the Author - for the record
12 February 2013
In view of the interest and responses to the controversy raised by the deaths following immunization with Pentavalent vaccine in India, I would like to update the earlier response.
Intention of NTAGI to Study AEFI
Drs Phadke and Menon suggest that the NTAGI introduced Pentavalent vaccine in just two States, because “simultaneous nationwide rollout (would have been) logistically challenging.” In our res Read More... -
http://www.bmj.com/content/341/bmj.c4001/rr/631967
Jacob Puliyel
Author response to Flegg: Pentavalent vaccine death-rate is 70 times the SIDS rate of the USA
19 February 2013
I thank Dr Peter Flegg for his continued interest in our paper and our response to the comments made by him. I am however surprised that he has not heard of skin testing for sensitivity to penicillin. The link here refers to a ‘Mayo Clinic’ article about skin testing in this context, written without medical jargon such that non-medical health policy planners can also und Read More... -
http://www.bmj.com/content/341/bmj.c4001/rr/632448
Jacob Puliyel
Pentavalent Vaccination and the Infant Mortality Rate
22 February 2013
The rapid response section of the BMJ promises to publish anything that contributes to the discussion. Repeating what I have said previously does not contribute anything new, but I hope I can clarify some of the points Dr Fleggs brings up in his last posting.
The comparison with IMR
The Pentavalent vaccine is being promoted in many Asian countries to reduce mortality in children. I wrote (posted 19/2/13) that the va Read More... -
http://blogs.bmj.com/bmj/2013/03/08/jacob-puliyel-on-the-all-india-centralised-entrance-test/
Jacob Puliyel
Jacob Puliyel on the All India centralised entrance test
8 Mar, 13 | by BMJ Group
jacob_puliyelFinal year medical students in the UK currently face an uncertain future as they wait to find out what foundation school place they have been allocated following the muddled “situational judgement test” (SJT). They can take cold comfort in the fact that at least they do not have to do the All India Centralised Entrance Test (CET) that students in India have to take.
There are far m Read More... -
Medical Journal of Dr. D.Y. Patil University | January-March 2013 | Vol 6 | Issue http://www.mjdrdypu.org/temp/MedJDYPatilUniv613-3047544_082755.pdf
Jacob Puliyel
Medical Journal of Dr. D.Y. Patil University | January-March 2013 | Vol 6 | Issue 1 3
The Pune Mirror of the 26
th
of August 2012 reports that
the Indian Academy of Pediatrics (IAP) has declared that
pneumonia is a leading cause of death (responsible for
410,000 childhood deaths annually) and recommended that
the Government of India should include free vaccines for
pneumonia and rotavirus in their immunization schedule.
The reporter noted that the IAP’s 2-day training program
at Read More... -
Express Pharma http://pharma.financialexpress.com/sections/res/1971-pentavalent-vaccine-doing-more-harm-than-good
Jacob Puliyel
Jacob Puliyel, Head of Pediatrics, St Stephens Hospital Delhi, questions whether the time has come to stop using Pentavalent vaccine for immunisation
Immunisation with the new Pentavalent vaccine resulted in the recent death of two babies in Kerala. This combination vaccine was to replace the trivalent DPT (against diphtheria, whooping cough, tetanus vaccine) and additionally protects against Haemophilus influenzae type b and Hepatitis B. The post mortem certificate in both babies stated: &ld Read More... -
Prashant Bhushan on behalf of the petitioners
IN THE HIGH COURT OF DELHI AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
C.M. No. OF 2013
IN
WRIT PETITION (CIVIL) No. 13698 OF 2009
PUBLIC INTEREST LITIGATION
IN THE MATTER OF:
DR. K. B. SAXENA & ORS. �PETITIONERS
VERSUS
UNION OF INDIA & ORS. �RESPONDENTS
APPLICATION FOR AMENDMENT OF PRAYERS OF THE WRIT PETITION UNDER SECTION 151 CPC
To,
The Hon�ble Chief Just Read More... http://www.youtube.com/watch?v=YE4IIGTzWdY
Mishal Husain, Hamid Jafari, Shahnaz Wazir Ali
Published on May 8, 2013
Mishal Husain was joined on the Impact programme by Dr Jacob Puliyel, head of Pediatrics at St Stephens Hospital from Delhi, and in the studio by the World Health Organisation's Polio Director Hamid Jafari, and Shahnaz Wazir Ali, the Government of Pakistan's special adviser on polio.
-
Indian J Med Res 137, April 2013, pp 639-641,
Jacob Puliyel
Making a case for universal Hib immunization in India; over interpreting the data
This issue of the IJMR features the results of a prospective sentinel surveillance for Hemophilus influenza B (Hib) meningitis. (1) The National Technical Advisory Group on Immunization (NTAGI) in its meeting of 26 August 2010 recommended that Pentavalent vaccine containing Hib be introduced in the states of Kerala and Tamil Nadu. (2) Since there was concern about its adverse effects (AEFI), this was to be monit Read More... -
IANS republished in various including http://en-maktoob.news.yahoo.com/misplaced-hoopla-over-indian-anti-diarrhea-vaccine-062414862.html and Indian Express http://newindianexpress.com/nation/Misplaced-hoopla-over-Indian-anti-diarrhea-vaccine/2013/06/25/article1652305.ece
Jacob Puliyel
Misplaced hoopla over Indian anti-diarrhea vaccine
IANS By Jacob Puliyel | IANS
Newspapers and television channels in India and abroad were abuzz recently with reports that an Indian rotavirus (anti-diarrhea) vaccine had been developed and tested. We were told that the vaccine, called Rotavac, is to be sold at $1/dose (Rs.60) compared to the existing brands costing $10-$50/dose. The announcement was made at a symposium on rotavirus vaccine in New Delhi.
Many doctors and scientists were h Read More... Report to ICMR Public Report on Health: Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States
C Sathyamala, N J Kurian, Anuradha De, K B Saxena, RituPriya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, SnehKhalsa, Ashish Puliyel, Jacob Puliyel.
Public Report on Health:
Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States
C Sathyamala, N J Kurian, Anuradha De, K B Saxena, RituPriya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, SnehKhalsa, AshishPuliyel, Jacob Puliyel.
On behalf of the Public report on Health
Address for correspondence
Jacob Puliyel
Department of Pediatrics
St Stephens Hospital
Delhi 110054
puliyel@gmail Read More... -
Indian Journal of Medical Ethics Vol X No 3 July-September 2013 Pages 142-6. http://ijme.in/pdfs/213ed142.pdf
Jacob Puliyel
EDITORIAL
AEFI and the pentavalent vaccine: looking for a composite picture
JACOB PULIYEL1
PDF
Georg Christoph Lichtenberg's reference to "a knife without a blade, for which the handle is missing" has been illustrated recently by Broomberg and Oliver Chanarin (1). In his work, Jokes and their relation to the cognitive unconscious, Freud suggested that the "knife without a blade which has no handle" is as absurd or funny as a "frame without a picture" Read More... -
Medical Science Monitor http://www.medscimonit.com/download/index/idArt/889695
Jacob Puliyel
Prone to survive and the priority rule in science
Jacob Puliyel
Corresponding Author: Jacob Puliyel, e-mail: puliyel@gmail.com
Source of support: None
In 2005 we published the first study to show that mortality can be reduced by prone ventilation [1]. This study
followed the large trial by the Prone-Supine Study Group of Gattinoni and colleagues published in the NEJM in
2001 [2] and another in 2005 that failed to show benefit [3].
We have speculated that the earlier trials failed to show Read More... -
BMJ 2013;347:f5187 doi: http://www.bmj.com/content/347/bmj.f5187?ijkey=c2KsVOga5BVB6M5&keytype=ref
Jacob Puliyel
Vaccine utilization rather than disease mitigation is the target
8 August 2013
Including vaccines in the routine immunization programmes of countries has become a kind of fetish with the WHO – disconnected from its purpose of reducing disease. Thus the WHO has recommended Hepatitis B vaccine for all countries. It has recommended that at least 3 doses of the vaccine must be used in each person regardless of whether it is given at birth, in infancy or during adolescence. (1) Vaccinating Read More... -
http://news.yahoo.com/unfortunate-story-37-deaths-good-vaccine-083414585.html
Jacob Puliyel
The unfortunate story of 37 deaths from a ‘good vaccine’ (Comment, Special to IANS)
On October 11, two children died in Kashmir after receiving the Pentavalent vaccine, taking to six the total deaths there in one week and to eight the deaths over the last three weeks. According to reports appearing in local newspapers, the deaths were said to be an allergic reaction to the vaccine. These deaths come on the heels of a press release from the health ministry on October 10 that a com Read More... -
VIR/13/2011/ECD-1 dated 20.9.2013
St Stephens Hospital to Administer multi-center study. Rs 44,99,760. 00 grant sanctioned from ICMR. Principal Investigator Jacob Puliyel. Collaborators Arvind Lal, Neelum Tripathi, Nimmi Kausal, Kishore Agarwal, Pramod Upadhyaya. Participating Centers Lals Laboratories, National Institute of Immunology, Sardanmal Kaandaka Memorial Hospital Jaipur, St Stephens Hospital Delhi.
-
http://webmedcentralplus.com/article_view/35
Puliyel J, Vashisht N, Sreenivas V.
Background
Although the incidence of polio acute flaccid paralysis (AFP) is coming down in India, the non-polio AFP (NPAFP) rate has increased. Nationwide, the NPAFP rate is 13.7/100,000 where the expected rate is 1-2/100,000. We examined the correlates of NPAFP, to discern explanations for the increase.
Methods
National Polio Surveillance data 2000-2012 was used. Differences between states and changes over time were examined. Demographic factors and polio programme parameters were ass Read More... -
Yojana Feb 2014 http://yojana.gov.in/
Jacob Puliyel
National Technical Advisory Group on Immunization (NTAGI): Challenges of moving past the paternalistic paradigm to allow greater public participation in vaccine decisions
The practice of medicine traditionally, used to be a paternalistic affair – with the doctor telling the patient what to do and the patient being expected to follow orders. The wishes, feelings, beliefs and values of the patient did not merit much consideration. The arrogant assumption was that the doctor knows best. Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/23773596#cm23773596_2581
Pinky Bahl MD, Supriya Rastogi DCH, Jacob Puliyel MD
Impact and cost-effectiveness of Haemophilus influenzae type b conjugate vaccination in India.
Clark AD.J Pediatr. 2013. PMID:23773596 In: PubMed Commons [Internet]. Bethesda (MD): National Library of Medicine; 2014 Feb 4. Available from: http://www.ncbi.nlm.nih.gov/myncbi/puliyel/comments/
Comment
Jacob Puliyel
This comment has been written after correspondence through the journal with the authors.
The WHO considers programmes cost-effective, if they cost less than 3 X GDP per capita Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2587
Jacob Puliyel
Jacob Puliyel2014 Feb 04 1:10 p.m.
DEATHS IN DEVELOPING COUNTRIES WILL COUNT FOR LESS
Tozzi et al describe causality assessment for AEFI using criteria from the CIOMS/WHO working group on pharmacovigilence . AEFI is any untoward medical occurrence following immunization. A causal relationship is not implied. The Brighton collaboration classified reactions as very likely/certain; probable; possible; unlikely; unrelated; unclassifiable, based on temporal criteria and evidence of alternate etiol Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2587
Jacob Puliyel
Assessment of causality of individual adverse events following immunization (AEFI): a WHO tool for global use.
Tozzi AE.Vaccine. 2013.Comment
In: PubMed Commons [Internet]. Bethesda (MD): National Library of Medicine; 2014 Feb 4. Available from: http://www.ncbi.nlm.nih.gov/myncbi/puliyel/comments/
Jacob Puliyel
DEATHS IN DEVELOPING COUNTRIES WILL COUNT FOR LESS
Tozzi et al describe causality assessment for AEFI using criteria from the CIOMS/WHO working group on pharmacovigilence . Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_2881
Jacob Puliyel
Jacob Puliyel2014 Feb 20
Tozzi and colleagues state that their article describes the new tool for causality assessment of AEFI as set out in the User Manual for the Revised WHO Classification
1) However this manual it seems has been developed without adequate care and without thinking through the consequences of the changes.
a) One pointer to this is how the manual cites an example of vaccines being wrongly blamed for events unrelated to its administration (Page 13). It says that vaccines w Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/19061929#cm19061929_3193
Jacob Puliyel
IT IS EXPEDIENT BUT IS IT PRUDENT TO LABEL ADVERSE EVENTS FOLLOWING IMMUNIZATION AS 'NOT AN EVENT OF [AEFI]'?
The old scheme of monitoring signals for vaccine safety (adverse events following immunization � AEFI monitoring), of the Advisory Committee on Causality Assessment Collet JP, 2000 has been overtaken by the Revised WHO Classification of AEFI. The changes have been described in 4 PubMed articles Tozzi AE, 2013, Bonhoeffer J, 2009, Halsey NA, 2012, William Read More... -
Jacob Puliyel
6500 PENTAVALENT-VACCINE AEFI-DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE
I thank Dr Malik for endorsing my opinion that the AEFI guidelines need to be revised. Unfortunately neither Tozzi and colleagues, nor [Bonhoeffer et al](http://www.ncbi.nlm.nih.gov/pubmed/19061929#cm19061929_3193) <PMID: 19061929> have responded and we do not know if the authors agree with us.
Dr Malik’s comment points out that India lacks a strong system of AEFI surveillance and investigation. Thi Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_3394
Jacob Puliyel
6500 PENTAVALENT-VACCINE AEFI-DEATHS IN INDIA EACH YEAR CANNOT BE ACCEPTABLE
I thank Dr Malik for endorsing the opinion that the AEFI guidelines need to be revised. Unfortunately neither Tozzi and colleagues, nor Bonhoeffer et al (Bonhoeffer J, 2009) have responded and we do not know if the authors agree with us.
Dr Malik�s comment points out that India lacks a strong system of AEFI surveillance and investigation. This is undisputable. The fact of this poor surveillance i Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24021304#cm24021304_3490
Jacob Puliyel
Jacob Puliyel2014 Mar 18 12:28 p.m. (just added)
Dr Malik, as part of the India Government Ministry of Health, has information on the AEFIs with Pentavalent vaccine and their investigation. I mention individual instances because Dr Malik is familiar with them and it best illustrates the harm done by the new system of AEFI classification.
Of the 54 deaths reported to the Government of India some have been investigated and the AEFI reports are available here
The deaths as described below Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/23452584#cm23452584_3553
Jacob Puliyel
Williams and colleagues have described assessment of AEFI employing the algorithm described by Halsey < PMID: 22507656>.
I have posted two very detailed comments to an article by Tozzi Tozzi AE, 2013 which discusses the same subject of the revised WHO Classification of AEFI. I will not repeat the points I have made there but it may be viewed here.
As this is a matter of patient safety I think it is important that the experts who understand the new scheme must explain why the revision Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_3808
Saurabh Kumar, Jacob Puliyel
Jacob Puliyel2014 Apr 04 3:26 p.m. edited
MINISCULE RISK REDUCTION MAKES $1 ROTAVIRUS VACCINE (116E) UNECONOMICAL IN INDIA
The authors must be congratulated for this study and the candid reporting of the absolute risk reduction (ARR) and numbers needed to treat (NNT).
LOW DISEASE BURDEN
Although rotavirus vaccine efficacy is lower in developing countries, it is advocated for poor countries because of the higher disease burden. Severe rotavirus gastroenteritis (SRVGE) was more common Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_3970
J Puliyel
50% More Intussusception Among Vaccinated: Full Trial Data Is Awaited
According to the Clinical Trials Registry this study, started in March 2011 was estimated to be complete in April 2014.
The data published in Lancet on March 12, 2014 refers only to the first half of the study (efficacy and safety of ORV 116E assessed in the first year of life). Data on efficacy and safety up to 2 years (from 14 days following the 3rd dose till the age of 2 years (24 months) + up to 14 days.) is still aw Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629994#cm24629994_4036
Jacob Puliyel
The authors have not responded to my invitation to participate in this discussion on the PubMed Commons as yet.
One of the authors Professor Gagandeep Kang has however sent a response to another discussion group discussing the comment. I will quote her concluding statement below.
“While I agree with Dr. Puliyel that AEFI surveillance is essential (and more critically, providing increased access to care in any medical emergency), I would question the ethics of waiting for Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/23964090#cm23964090_4600
Jacob Puliyel
Post-marketing surveillance cannot properly estimate risks
The authors must be congratulated for conducting a study whose scope was so vast. However it must be recognized that RCTs are the best method to look for risks and benefits. Post-marketing surveillance is relied on to detect rare adverse events. It has severe limitations in quantifying the magnitude of risks. The present study highlights the problem well.
1 The authors estimate the risk of intussusceptions (IS) in two window period Read More... -
Journal of Clinical and Diagnostic Research [serial online] 2014 May [cited: 2014 May 24 ]; 8:PC06-PC12. http://www.jcdr.in/pdf_download.asp?issn=0973-709x&year=2014&month=May&volume=8&issue=5&page=PC06-PC12&id=4389
C Sathyamala, NJ Kurian, Anuradha De, KB Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, Sneh Khalsa, Ashish Puliyel, Jacob Puliyel
Public Report on Health:
Development of a Nutritive Value Calculator for Indian Foods and Analysis of Food Logs and Nutrient Intake in 6 States
C Sathyamala, N J Kurian, Anuradha De, K B Saxena, Ritu Priya, Rama Baru, Ravi Srivastava, Onkar Mittal, Claire Noronha, Meera Samson, Sneh Khalsa, AshishPuliyel, Jacob Puliyel.
On behalf of the Public report on Health
Address for correspondence
Jacob Puliyel
Department of Pediatrics
St Stephens Hospital
Delhi 110054
puliyel@gmail Read More... -
J Matern Fetal Neonatal Med, 2014; 27(S1): 436-7
P. Tyagi, N. Gupta, A. Jain, P. Upadhyay, & J. Puliyel
Brief Introduction: Although bubble CPAP is seen to be superior to
continuous steady pressure CPAP, it is reported that its pressure
delivery system can be highly variable and unpredictable. CPAP has
been associated with gastrointestinal adverse effects – although
rarely. The CPAP belly syndrome is one such adverse effect characterised by gaseous
bowel-distension in infants treated with nasal CPAP.
The pressures transmitted from oropharynx to stomach during
BCPAP are no Read More... -
BMJ Open 2014;4:e003545 doi:10.1136/bmjopen-2013-003545
Akanksha Jain. Prashant Tyagi, Prabjeet Kaur, J Puliyel, V Sreenivas
Abstract
Objectives and hypothesis To examine the influence of gender of the baby on exclusive breastfeeding and incidence of postnatal depression (PND). We hypothesise that in a society with a male gender bias there may be more PND and less exclusive breastfeeding of the girl child.
Design Prospective study.
Setting The study was conducted in an urban, tertiary hospital in Delhi.
Participants Mothers delivering normally with their babies roomed-in.1537 eligible women participated in Read More... -
http://www.moneylife.in/article/why-more-vaccines-wont-translate-to-better-health/38107.html
Jacob Puliyel, B M Hegde
Moneylife » Life » Wellness » Why more vaccines won't translate to better health
Why more vaccines won't translate to better health
Dorit Reiss
Dorit Reiss
2 comments
+ COMMENT
Dr Jacob Puliyal & Professor BM Hegde | 16/07/2014 12:24 PM |
If vaccination was such a good method of disease prevention we should have been able to eradicate many contagious disease, but alas, records show that except small Read More... -
Indian Pediatr. 2014 Jul 8;51(7):565-7. http://www.indianpediatrics.net/july2014/565.pdf
Munde A, Kumar N, Beri RS, Puliyel JM.
Objectives
: To correlate lactate clearance with Pediatric Intensive Care Unit (PICU)
mortality.
Methods
: 45 (mean age 40.15 mo, 60% males) consecutive admissions in the
PICU were enrolled between May 2012 to June 2013. Lactate clearance (Lactate level at
admission – level 6 hr later x 100 / lactate level at admission) in first 6 hours of hospitalization
was correlated to in-hospital mortality and PRISM score.
Results
: Twelve out of 45 patients
died. 90% died among Read More... -
The Hindu Delhi Page 4
Dr Maturam Santosham from Johns Hopkins School of Public Health USA, and co-chairman of the ROTA Council has written in The Hindu on the need to turn the corner on child health (31/7/14). However his prescription appears seriously flawed. He writes impassionedly in favor of introducing the Rotavirus vaccine saying that the average cost of hospitalization for each episode of rotavirus diarrhea is Rs 3000.
However the paper published in the Lancet states that the vaccine that has now been license Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/25091689#cm25091689_5704
J Puliyel
Intussusception in southern India: Comparison of retrospective analysis and active surveillance.
Jehangir S.Vaccine. 2014.1 comment
Jacob Puliyel2014 Aug 12 08:51 a.m. (4 hours ago)edited
I congratulate the authors of this analysis. However their analysis begs more questions than it answers.
They found that there were 581 cases of ultrasound diagnosed intussusception per 100,000 child years, during the Rotavirus trial, which works out to be 1 intussusception in every 172 children, ea Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/25091663#cm25091663_5692
Puliyel J
Jacob Puliyel2014 Aug 12 01:11 a.m. (12 hours ago)
I read with interest this paper that describes efficacy and safety of the 116E rotavirus vaccine in the 2nd year of the trial. The results for the first year were published earlier in June 2014 Bhandari N, 2014. The authors need to be congratulated for this study.
However some of the data appears incongruous. According to the clinical trial registry http://clinicaltrials.gov/show/NCT01305109 one of the secondary outcome measures was to be &qu Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/25091662#cm25091662_5770
Puliyel J
Licensing the vaccine for general use (in remote areas of India), seems impossible to justify
I commend Dr John and colleagues for this report on the trial with the 116E Indian rotavirus vaccine. However the authors limit their discussion to comparisons with the trials of Rotarix and Rotateq which recruited some 60,000 patients each. It will be more useful to compare the 116E trial safety results with the RotaSheild vaccine trials http://www.path.org/vaccineresources/files/RotaShield_Fact_She Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5773
J Puliyel
**Team science must not be allowed to influence objectivity**
**Projections of deaths exaggerated 5 times**
The authors must be congratulated for describing the team effort involved in the development of the new 116E rotavirus vaccine. In this process the Government of India through its funding of the Department of Science and Technology, the Bill and Melinda Gates foundation and PATH; all became partners who had a stake in getting this vaccine licensed and commercialized. Objectivity can Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5899.
Puliyel J
Abstract
Send to:
See comment in PubMed Commons below
Lancet. 2014 Jun 21;383(9935):2180-3. doi: 10.1016/S0140-6736(14)60191-4. Epub 2014 Mar 12.
Team science and the creation of a novel rotavirus vaccine in India: a new framework for vaccine development.
Bhan MK1, Glass RI2, Ella KM3, Bhandari N4, Boslego J5, Greenberg HB6, Mohan K3, Curlin G7, Rao TS8.
Author information
PMID:
24629993
[PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24629993#cm24629993_5899
J Puliyel
The time lines described by Professor Bhan <PMID: 24629993> suggest that the private manufacturer to set up the plant for manufacture of this vaccine was funded by PATH, B&MG and the Government of India (DBT) in 2000, where as the Phase 3 trial only started in 2008. It is clear that regardless of efficacy in the phase 3 trial (or any objections by NTAGI members,) the vaccine had to be rolled out, if there was to be any returns on the investment.
I am less concerned about this waste Read More... -
http://economictimes.indiatimes.com/opinion/comments-analysis/governments-uip-pressure-from-international-organizations-to-include-vaccines-for-other-diseases/articleshow/41280844.cms Also see http://m.economictimes.com/industry/healthcare/biotech/healthcare/Controversial-vaccine-studies-Why-is-Bill-Melinda-Gates-Foundation-under-fire-from-critics-in-India/articleshow/4128
Jacob Puliyel
-
The Indian Journal of Pediatrics February 2015, Volume 82, Issue 2, pp 131-135. Ind J Pediatr. 2014 Sep 4. [Epub ahead of print] PMID: 25186564
Prashant Tyagi, Neeraj Gupta, Akanksha Jain, Jacob Puliyel, Pramod Upadhyay
INTRA GASTRIC PRESSURES IN NEONATES RECEIVING BUBBLE CPAP
Prashant Tyagi1, Neeraj Gupta1, Akanksha Jain1,Jacob Puliyel1, Pramod Upadhyay 2
(1) Department of Paediatrics and Neonatology, St. Stephen’s Hospital, New Delhi.
(2) National Institute of Immunology, New Delhi.
Address for communication
Prashant Tyagi
C/O Jacob Puliyel
Deptt. of Paediatrics
St Stephens Hospital
Tis Hazari
Delhi 11054
Email puliyel@gmail.com
ABSTRACT
Obje Read More... -
The Road to Universal Health Coverage. 12th India Infrastructure Report. 2013-14. Chapter 16 Page 203 to 212 IDFC FoundationOrient BlackSwan New Delhi ISBN 978 81 250 5610 2 http://www.idfc.com/pdf/report/2013-14/Chapter-16.pdf
Jacob Puliyel
The last two decades have been the era of public-private
partnerships (PPPs). The Saskatchewan Institute of
Public Policy defines PPPs as co-operative ventures
between public and private sectors, built on the expertise
of each partner which meets clearly defined public needs
through appropriate allocation of resources, risks and
rewards (Allan 2001).
A particularly important element is the emphasis upon
risk-sharing, joint investment of resources, and sharing
of authority. These factors Read More... -
Indian Journal of Medical Ethics Vol XI No 4 October-December 2014. http://www.issuesinmedicalethics.org/index.php/ijme/article/view/2132/4598
RITIKA CHHAWCHHARIA , JACOB M, PULIYEL
TITLE: Controversies surrounding mercury in vaccines: autism denial as impediment to universal immunisation
AUTHORS: RITIKA CHHAWCHHARIA1, JACOB M PULIYEL2
AFFILIATIONS: 1Senior Registrar, Department of Paediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054 INDIA 2Consultant Paediatrician and Head of Department of Paediatrics, St Stephens Hospital, Tis Hazari, Delhi 110 054 INDIA Author for correspondence: Jacob M Puliyel e-mail: puliyel@gmail.com
In 2004, the US Center for Disease Read More... -
Indian Pediatrics 2014;51:870-2 http://www.indianpediatrics.net/nov2014/870.pdf
RAJEEV KUMAR AND JACOB PULIYEL
Utility of Hepatitis B Vaccination in India
Global health interventions are being scrutinized more closely than previously. According to an article in Science, the Center for Global Development in Washington has begun looking for hard evidence in real-life field conditions, whether a large-scale interventions have directly led to lower numbers of cases or deaths and whether the improvements are sufficient to justify the costs.(1)
This issue of Indian Pediatrics has a limited evaluation of t Read More... -
Nil
Professor BM Hegde MD, PhD (Hon. Causa), FRCP (London), FRCP (Edinburgh), FRCP (Glasgow), FRCPI (Dublin), FACC, FAMS. Dr Vikas Bajpai Professor Amitav Banerjee Dr J P Dadhich MD Dr Arun Gupta MD FIAP Professor S K Mittal Professor Ritu Priya MBBS, Ph.D. Dr Jacob Puliyel MD MRCP M Phil Professor S Srinivasan MD Professor KP Kushwaha
Date: 25th November 2014
To
The Prime Minister
Prime Minister’s Office
South Block
Raisina Hill
New Delhi-110011
Sir
Subject: Concerns about deaths of young children following Pentavalent Vaccine
Every few days one more child dies after receiving the Pentavalent vaccine.
The Deccan Herald of 22 August 2014 reported 2 more deaths from Haryana with the Pentavalent vaccine (http://www.deccanherald.com/content/427027/2-kids-die-vaccination-haryana.html).
Read More... -
Indian J Pediatr. 2015 May;82(5):490.
Pinky Bahl, Jacob Puliyel
The Indian Journal of Pediatrics
© Dr. K C Chaudhuri Foundation 2014
10.1007/s12098-014-1648-4
Correspondence
Decline in Immunization Coverage Across Well-performing Districts in India: An Urban Conundrum? Correspondence
Pinky Bahl1 and Jacob Puliyel1
(1)
Department of Pediatrics, St. Stephens Hospital, Delhi, 110054, India
Pinky Bahl
Email: drpinkybahl@gmail.com
Received: 28 October 2014Accepted: 1 December 2014Published online: 16 December 2014
Without Abstract
Read More... -
Excellence in Pediatrics (EiP) Dubai 4 to 6 December 2014
N. Vashisht, J.M. Puliyel, V. Sreenivas
Trends in Non-Polio Acute Flaccid Paralysis incidence in India 2000-2013
N. Vashisht
J.M. Puliyel*
V. Sreenivas**
Department of Pediatrics, Jaypee Hospital, Sector-128, Noida, Gautam Buddh Nagar-201304, UP
*Department of Pediatrics, St. Stephen's Hospital, Tis Hazari, Delhi 110054, India
**Department of Biostatistics, All India Institute of Medical Sciences, New Delhi – 110029, India
Short title: Non-Polio Acute Flaccid Paralysis
Key words: Acute flaccid par Read More... -
Response to http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656
Dr Normn Begg
GlaxoSmithKline Vaccines SA
Avenue Fleming 20
B-1300 Wevre
Belgium
Tel +32 (0)10853700
Via email: puliyel@gmail.com
Jacob Puliyel, MD MRCP M Phil Head of Pediatrics St. Stephens Hospital Dehli, India
Wavre, 14 January 2015
Dear Dr. Puliyel,
Your email dated 12 January 2015 addressed to Sir Andrew Witty in which you make reference to GlaxoSmithKline’s Infanrix-hexa Periodic Safety Update Report (PSUR) for the period 23 October 2009 to 22 O Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656
Jacob Puliyel
Baldo and colleagues quote 2 references to suggest that in Germany, a population-based evaluation demonstrated a possible safety signal for DTPa-HBV-IPV-Hib-SP but failed to show an imbalance between observed and expected SUD cases for DTPa-HBV-IPV/Hib <PMID:15602672> <PMID:16081190>. However this seems to be contradicted by the data that was submitted by the manufacturer to the regulatory authority and the analysis below.
The GlaxoSmithKline Biological Clinical Safety and P Read More... -
Indian Pediatrics 2015;51:81-2 http://indianpediatrics.net/jan2015/80.pdf
Anoop Sharma, Jacob Puliyel
I
NDIAN
P
We read with interest the IAP Committee on Immunization
(IAPCOI) recommendation on MMR vaccine at 9 months
of age [1]. In this context, we studied the 2014
immunization practices across 121 countries, including 4
countries in Africa, 34 in the Americas, 13 in the Eastern
Mediterranean region, 51 in Europe, 15 Western Pacific countries and 4 South East Asian countries. In none of
these countries is MMR given at 9 months, except
Mongolia and Thailand. Germany uses it between 11 Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8719
Jacob Puliyel
Apropos the earlier posting there are a couple of other facts that we must consider when looking at the incidence of sudden unexplained deaths immediately following vaccination with Infanrix.
a) The safety assessment document has used the number of doses of vaccine distributed as the denominator. The report acknowledges that all the doses of the vaccine distributed, need not have been utilized.
There can be another argument against using this denominator. As each child is given up to Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8767
Jacob Puliyel
I thank the authors for their response to my comment.
I was presuming that in the countries from where this data was gathered, sudden infant death or SIDS is considered 'unnatural death'. If that is so, these deaths will have been investigated by a competent forensic team and the immunization records will have been examined to check if the infant was up to date with its vaccinations or whether there was an element of neglect. Reporting bias (based on parents perception that vaccine Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8656
Jacob Puliyel
I thank Ferenci and Miller for their responses. I will address the three points made by Dr Ferenci
1) The data I have quoted (from Table 36) was made available by the manufacturers GSK, to defend the safety record of Infanrix Hexa to the regulatory authority (- the EMA). The data suggests a cluster on and following the day of vaccination. If the reporting is so bad the clusters aren't real, then the data can't/shouldn't be used to defend its safety. If the reporting is good, th Read More... -
Pediatrics. 2015 Feb;135 Suppl 1:S16-7. doi: 10.1542/peds.2014-3330DD. PMID: 26005734
Vashisht N, Puliyel J, Sreenivas V.
Trends in Non-Polio Acute Flaccid Paralysis incidence in India 2000-2013
N. Vashisht
J.M. Puliyel*
V. Sreenivas**
Department of Pediatrics, Jaypee Hospital, Sector-128, Noida,GautamBuddh Nagar-201304, UP
*Department of Pediatrics, St. Stephen's Hospital, Tis Hazari, Delhi 110054, India
**Department of Biostatistics, All India Institute of Medical Sciences, New Delhi – 110029, India
Short title: Non-Polio Acute Flaccid Paralysis
Key words: Acute flaccid paral Read More... -
http://www.ncbi.nlm.nih.gov/pubmed/24004825#cm24004825_8998
Jacob Puliyel
Jacob Puliyel2015 Feb 06 1:11 p.m. (4 days ago)
Dear Dr Ferenci
The EMA I understand is obliged by European Union law to engage the precautionary principle. Until the full scientific evidence is available, where there is evidence of risk, it must take precautionary measures. The comments here indicate the evidence is of more than a risk, but of the harm itself.
You say Dr. Franco cited studies that Infanrix Hexa is safe. Which ones and where? I can see Dr Franco has cited WHO and CDC statemen Read More... -
Vaccine. 2015 Mar 20. pii: S0264-410X(15)00293-5. doi: 10.1016/j.vaccine.2015.03.007
Jalaj Bajaj, Jacob M. Puliyel
Letter to the Editor
Intussusception risk with 116E rotavirus vaccine in Vellore, South India
Jalaj Bajaj
Jacob M. Puliyel
puliyel@gmail.com
St Stephens Hospital Delhi. Stephens Hospital, Delhi, India
âŽCorresponding author. Tel.: +91 9868035091 We congratulate John and colleagues for their surveillance of intussusception during the 116E rotavirus vaccine trial [1]. They point out that it is critical to be vigilant to the risk of intussusception “to determine if Read More... -
http://www.bmj.com/content/350/bmj.h2867/rapid-responses
Jacob M. Puliyel
BMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h2867 (Published 27 May 2015) Cite this as: BMJ 2015;350:h2867
Article
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Response
116 E Rotavirus Vellore Study: Request for Vaccine Safety Data
The report contains a number of misleading assertions and a fundamental misunderstanding of statistics. These need to be corrected.
The Rotavirus 116E trial was registered with the Clinical Trials Registry ClinicalTrials.gov Read More... -
W.P.(C) 1524/2015
Prashant Bhushan and Neha Bharadwaj for Jacob Puliyel
IN THE HIGH COURT OF DELHI, AT NEW DELHI
(CIVIL ORIGINAL JURISDICTION)
Writ Petition (Civil) No. W.P.(C) 1524/ of 2015
A WRIT PETITION IN PUBLIC INTEREST UNDER ARTICLE 226 OF THE CONSTITUTION OF INDIA SEEKING A WRIT DIRECTING THE RESPONDENTS TO PROVIDE COMPLETE DATA OF THE RESULTS OF A MULTICENTRE CLINICAL TRIAL OF ROTAVIRUS VACCINE DONE ON INFANTS.
MEMO OF PARTIES
In the matter of Public Interest Litigation:
JACOB PULIYEL, MD, MRCP MPhil
ST STEPHENS HOSPITAL
DELHI 110054 ..&acir Read More... -
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140807
Jitendra Piple, Ranjeet Gora, Pragati Purbiya, Ashish Puliyel, Parul Chugh, Pinky Bahl, Jacob Puliyel
Abstract
Introduction
Although economic development is generally accompanied by improvements in the overall nutritional status of the country’s population the ‘nutritional transition’ often involves a shift to high energy diets and less exercise with negative consequences. This pilot study was done to examine if education of parents operates at the household level to influence dietary choices and the nutritional status of children in a Read More... -
Vaccine 33 (2015) 7142
Jiteendra Kumar Piple, Jacob Puliyel
116E Rotavirus Vaccine May Have Less Impact in India Than Projected
According to an article published in Science, impact evaluation of global health programmes is
becoming more stringent.(1) The Center for Global Development in Washington is demanding
hard evidence in real-life field conditions, whether interventions have directly led to lower
numbers of cases or deaths and whether the improvements are sufficient to justify the costs. In
this milieu we find that some of the projections in Read More... -
Indian Medical Parliamentarians' Forum Newsletter Volume 5 Number 3 Nov-Dec 2015 Page 4 http://clraindia.org/include/IMPFNewsletterNovember-December2015.pdf
Jacob Puliyel
Keeping Secrets from the PMO
Clinical trials are done on human volunteers who participate from altruistic motivations in what could be a dangerous enterprise. Prior informed consent must be obtained after full disclosure of the risks involved. If during the trial, it shows up unacceptable risks, the trial must be stopped.
Imagine a trial involving 6 week old infants. Their parents trustingly allow their babies to be experimented on. If the trial shows serious, statistically significant inc Read More... -
Sunday Guardian http://www.sundayguardianlive.com/news/3431-pmo-plea-ignored-rotavirus-vaccine-trial-results-must-be-made-public-immediately
Jacob Puliyel
The trial of the Rotavirus vaccine (called the 116E vaccine) in Vellore, Tamil Nadu, by the Christian Medical College, Vellore, and the Department of Biotechnology of the Government of India, has raised doubts about “ethical standards" in clinical trials. One is reminded of the Tuskegee experiment 40 years ago when black Americans were studied for progression of syphilis, without treatment and without their knowledge.
Imagine a trial involving six-week-old infants. The Read More... -
Sunday Guardian http://www.sundayguardianlive.com/opinion/3901-pm-modi-must-rescue-vaccine-programme-vested-interests
Jacob Puliyel
References links added
PM Modi must rescue vaccine programme from vested interests
Sunday Guardian http://www.sundayguardianlive.com/opinion/3901-pm-modi-must-rescue-vaccine-programme-vested-interests
Jacob Puliyel
Download (PDF) 2.2 MB
PM Modi must rescue vaccine programme from vested interests
By JACOB PULIYEL | 26 March, 2016
-------------------------------------
To ensure that the public is kept in the dark on formation of public health policy on vaccines the new secretariat Read More... -
Indian Pediatr 2016;53: 351 http://www.indianpediatrics.net/apr2016/351.pdf
Kanika Goyal and Jacob Puliyel
Inappropriately Small Sample for Studying Adverse Events Following Immunization
*Kanika Goyal and Jacob Puliyel
Department of Pediatrics, St Stephens Hospital, Delhi, India.
Email: gyl.knk@gmail.com
We refer to the study of common illnesses before and after vaccination [1]. The authors looked for symptoms like constipation, rash, wheeze, rhinitis and watering of eyes in 1602 children in the week after immunization, and found the frequency was same as in the week prior Read More... -
African Health Sciences Vol 16 Issue 2, June 2016 Page 356 - 62
Zainab Mohammedi Golwala, Hardik Shah, Neeraj Gupta, V. Sreenivas, Jacob. M. Puliyel
Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study.
Zainab Mohammedi Golwala1, Hardik Shah1, Neeraj Gupta1, V. Sreenivas2, Jacob. M. Puliyel1
1. Department of Pediatrics and Neonatology, St. Stephens Hospital, New Delhi. 2. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi.
Abstract Background: Thrombocytopenia has been shown to predict mort Read More... -
GoI
-
http://journals.plos.org/plosone/article/comment?id=info:doi/10.1371/annotation/efe0cd23-f453-4359-9372-0c977bd2c6b3 Response to Sudden Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Series Study Giuseppe Traversa, Stefania Spila-Alegiani , Clara Bianchi, Marta Ciofi degli Atti, Luisa Frova, Marco Massari, Roberto Raschetti, Stefania Salmaso, Gianpaolo Scalia Tomba, and the Hera Study Group PLOS Published: January 26, 2011 http://dx.doi.org/10.1371/journal.pone.0016363
Pooja Anthwal, Sonalika Mehta, Jacob Puliyel
Infanrix Hexa Periodic Safety Update Report (PSUR) to the EMA Compliments the Findings of Deaths with the Hexavalent Vaccine
Posted by Puliyel on 15 Oct 2016 at 10:55 GMT
With reference to the paper by Traversa and collaborators (1) we commend the monumental work, their meticulous collection of data and analysis. We however would like to make a few observations about the conclusions they have arrived at especially in the light of contemporaneous global data that has come in to the public doma Read More... -
S Srenivasan P Bhushan Neha Rathi
https://youtu.be/4aVNKN-dDaI
Jacob Puliyel
https://youtu.be/4aVNKN-dDaI
Thank you for inviting me for this national seminar on newer vaccines.
Slide 2
Chairperson Professor Imrana Quadir and distinguished delegates
Challenges in the investigation of adverse events following immunization.
I would like to do a quick question with you.
I tell you that I am interested in spreading a lie – some falsehood
I will divide this audience into two groups.
Those to my right I tell you I am willing to pay you 1 rupee eve Read More... -
8th Asian Conference of Pediatric Infectious Disease. 8 to 10 November 2016 Queen Sirkitt National Conference Center Bangkok, Thailand
Jacob Puliyel, Pathik Naik, Ashish Puliyel, on behalf of the ICMR Hepatitis B Study Group
High Levels of Natural HBsAb in Newborns in India - Protection against Hepatocellular Carcinoma
*# Jacob Puliyel1, Pathik Naik1, Ashish Puliyel2
1 St Stephens Hospital Delhi India
2 DocuBuzz Computer Solutions 02-12/25, The Franklin, 118223, Singapore,
#Puliyel@gmail.com
Introduction 4% of Indians is chronic Hepatitis B carriers. Extrapolating data from Taiwan it was estimated that 250,000 die each year of hepatocellular carcinoma (HCC). However, in India the Cancer Registry shows the inc Read More... https://youtu.be/iBGI4RkH_OQ 8th Asian Congress of Pediatric of Infectious Disease 8th - 10th November 2016 Queen Sirikit National Convention Center Bangkok Thailand
J Puliyel, Pathik Naik, A Puliyel
8th Asian Congress of Pediatric of Infectious Disease 8th - 10th November 2016
Queen Sirikit National Convention Center
Bangkok Thailand 1. Dr. Beasley was the first to discover of a virus that leads to human cancer. Beasley and his colleagues proved that hepatitis B virus (HBV) is a primary cause of liver cancer, and that a path of transmission is from mothers to infants during childbirth.
Working in Taiwan he concluded that 1 in 4 male carries of Hepatitis B would die of hepatocell Read More... -
Sunday Guardian 13-November 2016. http://www.sundayguardianlive.com/news/7314-237-deaths-pentavalent-vaccine-and-still-counting
Jacob Puliyel
Under Right to Information we know that up to August 2016 there have been 237 deaths reported to the government here within 72 hours of vaccination with Pentavalent. We examined deaths in states which were giving DPT and Pentavalent vaccine concurrently.
There were three deaths following the use of Pentavalent vaccine in Sri Lanka. The Government of Sri Lanka suspended the use of the vaccine. WHO experts investigated the deaths. They found there was a clear temporal association of the deaths Read More... -
medico friend circle bulletin M FC_Bulletin_Issue_Immunization_371-372.pdf July -November 2016 Available at Link: https://www.dropbox.com/s/6c7sqb0lsv23akc/MFC_Bulletin_Issue_Immunization_371-372.pdf?dl=0 Page 41-43
Jacob Puliyel
Don’t Trust me, I’m a Doctor:
AEFI and the Breakdown of Regulation
Jacob M. Puliyel
Department of Pediatrics
St Stephens Hospital
Delhi 110054
puliyel@gmail.com
 
Don’t Trust me, I’m a Doctor:
AEFI and the Breakdown of Regulation
In Europe the safety assessment reports on vaccines are filed confidentially with the regulatory authority namely the European Medical Agency (EMA). The Italian Read More... -
PubPeer https://pubpeer.com/publications/084192013B84A8BCE194C683D6473C#fb113357 Response to "Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study" Muriel Le Bourgeois, Agnès Ferroni, Marianne Leruez-Ville, Emmanuelle Varon, Caroline Thumerelle, François Brémont, Michael J Fayon, Christophe Delacourt, Caroline Ligier, Laurence Watier, Didier Guillemot, J. Pediatr., 175 (2016)
Rahi Masoom Raza, Neha Dalal, Jacob Puliyel
Antibiotic Use in Viral Infections May Reduce Empyema But The Associated Risk of Antibiotic Resistance is Unacceptable
The title of the paper by Bourgeois and colleagues "Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children" suggests that antibiotics must be used in viral infections along with NSAID antipyretics. (1) This suggestion is likely to increase irrational use of antibiotics in viral infections and enhan Read More... -
Writ 289 of 2016 Supreme Court of India
Dr Sunil Thomas Chandy Director CMC Vellore
-
Breastfeed Med. 2017 May 4. doi: 10.1089/bfm.2017.0024. [Epub ahead of print]
Goyal K, Purbiya P, Lal SN, Kaur J, Anthwal P, Puliyel JM.
Correlation of Infant Gender with Postpartum Maternal and Paternal Depression and Exclusive Breastfeeding Rates
AU1c Kanika Goyal, Pragati Purbiya, Sandeep N. Lal, Jaspreet Kaur, Pooja Anthwal, and Jacob M. Puliyel
Abstract
Introduction: Male bias in India has resulted in an altered sex ratio. It also results in maternal postpartum depression (PPD) and lower breastfeeding rates. We studied depression among fathers in this context. Methods: Edinburgh postnatal depression scale (EPDS) questio Read More... -
Indian Journal of Medical Ethics Vol II No 4 October-December 2017 Page 300-2. Available at http://ijme.in/articles/deaths-following-pentavalent-vaccine-and-the-revised-aefi-classification/?galley=html
J Puliyel, Anand Phadke
Deaths following pentavalent vaccine and the revised AEFI classification
Published online on July 4, 2017
We are concerned about the changes effected by the WHO to the assessment methodology of adverse events following immunisation (AEFI)(1), which make it almost impossible to classify adverse events (deaths in this case) noticed for the first time in phase IV post-marketing surveillance, as “consistent causal association to immunisationâ€.
The sequence of even Read More... -
http://www.bmj.com/content/357/bmj.j2449/rr-6
David Legge, Jacob Puliyel
Feature
US government website for collecting adverse events after vaccination is inaccessible to most users
BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j2449 (Published 19 May 2017) Cite this as: BMJ 2017;357:j2449
Enhancing Community Confidence in Vaccines Safety
The Global Advisory Committee on Vaccine Safety (GACVS) met on 7 and 8 June 2017.
WHO’s Executive Board, meeting in January, discussed the report of the mid-term review of the Global Vaccine Action Read More... -
https://scroll.in/pulse/844323/a-study-tries-to-prove-efficacy-of-a-rotavirus-vaccine-that-might-cause-more-diarrhoea
Jacob Puliyel
In March, the New England Journal of Medicine published the results of a clinical trial of a rotavirus vaccine developed by the Serum Institute of India. The paper highlighted that the vaccine reduced the incidence of rotavirus gastroenteritis and suggested that this new vaccine would be effective in controlling the disease. What the paper tries to gloss over is data from the trial that shows that the overall incidence of diarrhoea among those who received the vaccine actually increased rais Read More... -
N Engl J Med 2017; 377:302 July 20, 2017DOI: 10.1056/NEJMc1705793 Available at http://www.nejm.org/doi/full/10.1056/NEJMc1705793
Jaspreet Kaur, Jacob Puliyel
To the Editor:
Isanaka and colleagues (March 23 issue)1 tested a heat-stable rotavirus vaccine in Niger and report an efficacy of 66.7% against severe rotavirus gastroenteritis in the per-protocol population. The purpose of rotavirus vaccination is ultimately to reduce the incidence of diarrhea and diarrhea-related death. However, the rate of severe gastroenteritis due to any cause was not significantly lower among the vaccinated infants than among those who received placebo (difference in ra Read More... -
http://pediatrics.aappublications.org/content/140/1/e20163489.comments#re-seeing-voices-and-cochlear-implants
Sara Varughese, Pooja Anthwal, Jacob M. Puliyel
15 August 2017
RE: Seeing Voices and Cochlear Implants
Sara Varughese, Regional Director Christoffel Blindenmission (CBM), 140 Commerce Cube, Bangalore 560018 India
Other Contributors:
Pooja Anthwal, Resident in Pediatrics
Jacob M. Puliyel, Pediatrician and Head of Department of Pediatrics
Geers and colleagues, in a meticulously executed study, reported a delay in speech acquisition in patients using sign language prior to cochlear implantation (1). We fear that Read More... -
The Wire https://thewire.in/170941/pfizer-pneumonia-vaccine-patent/
Jacob Puliyel
With Pneumococcal Vaccine Patent, Pfizer Wins on Many Counts
By Jacob Puliyel on 25/08/2017
Not only was Pfizer given a subsidy to ‘develop’ a drug that already existed, the profits they will make from the inefficient vaccine is much beyond what was originally stipulated.
A company logo is seen through branches at a Pfizer office in Dublin, Ireland November 24, 2015. Credit: Reuters/Cathal McNaughton
A company logo is seen through branches at a Pfiz Read More... -
Indian J Pediatr Published online 26 August 2017 DOI 10.1007/s12098-017-2432-z
Pragati Purbiya, Zainab Mohammedi Golwala, Ayush Manchanda, V. Sreenivas, Jacob M. Puliyel
Platelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness
Pragati Purbiya 1,2✉ EmailPrags.89@gmail.com
Zainab MohammediGolwala1
Ayush Manchanda 1
V. Sreenivas 3
Jacob M. Puliyel 1
1Department of PediatricsSt Stephens HospitalTis HazariDelhiIndia
2B-39, Sudama NagarIndoreMadhya Pradesh452009India
3Department of BiostatisticsAll India Institute of Medical SciencesNew DelhiIndia
Abstract
Objective
To prospectively validate association bet Read More... -
Indian Journal of Medical Ethics http://ijme.in/articles/infanrix-hexa-and-sudden-death-a-review-of-the-periodic-safety-update-reports-submitted-to-the-european-medicines-agency/?galley=html
Jacob Puliyel, Sathyamala
COMMENT
Infanrix hexa and sudden death: a review of the periodic safety update reports submitted to the European Medicines Agency
Jacob Puliyel, C Sathyamala
Published online: September 5, 2017
Abstract
There have been a number of spontaneous reports of sudden unexpected death soon after the administration of Infanrix hexa (combined diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliomyelitis and Haemophilus influenza type B vaccine). The manufacturer, GlaxoSmithKlin Read More... -
Indian Pediatr. 2018 Jan 15;55(1):27-30. http://indianpediatrics.net/e-pub.htm
SANDEEP NARAYAN LAL, JASPREET KAUR, POOJA ANTHWAL, KANIKA GOYAL, PINKY BAHL AND JACOB M PULIYEL
ABSTRACT Objective: To evaluate the efficacy of nasal continuous positive airway pressure (nCPAP) in decreasing respiratory distress in bronchiolitis. Design: Randomized controlled trial. Setting: Tertiary-care hospital in New Delhi, India. Participants: 72 infants (age <1y) hospitalized with a clinical diagnosis of bronchiolitis were randomized to receive standard care, or nCPAP in addition to standard care, in the first hour after admission. 23 parents refused to give consent for participat Read More... -
Cancer. 2018 Jan 1;124(1):213-214 DOI: 10.1002/cncr.31075, Published online Month 00, 2017
Vivian Suman, Jacob M. Puliyel,
Cost-Effectiveness Calculations of Human Papillomavirus Vaccination in Punjab
May Be Flawed
Prinja et al1 looked at the cost-effectiveness of the human papillomavirus (HPV) vaccine for adolescent girls in Punjab, India. They assumed that the cost of vaccination would be US $14.1 per child. The report suggests a 90% probability that vaccination would be cost-effective in Punjab (at a willingness-to-pay threshold of 10,000 Indian rupees per quality-adjusted life-year gained, which is one-tenth o Read More... -
Cancer. 2018 Mar 1;124(5):1085 Version of Record online: 22 NOV 2017 | DOI: 10.1002/cncr.31167
Vivian Suman and Jacob M. Puliyel
The Reply to the Letter on the
Cost-Effectiveness of Human
Papillomavirus in Punjab Further
Distorts the Scientific Record
Articles in peer-reviewed scientific journals become part
of the scientific record. For this reason, the correspondence
column opens up the science to wider peer review as
part of the effort to uphold the scientific validity of published
science. We are concerned that the reply about the
cost-effectiveness of human papillomavirus vaccination in
Punjab1 is not entir Read More... -
http://www.tribuneindia.com/news/in-focus/dubious-vaccine-for-cervical-cancer/518412.html
Jacob Puliyel
Tribune Monday, December 25, 2017
In Focus
Posted at: Dec 25, 2017, 12:53 AM; last updated: Dec 25, 2017, 12:12 PM (IST)
Dubious vaccine for cervical cancer
Also in this section
Prevention is better than cure
Dubious vaccine for cervical cancer
Jacob Puliyel
Before a new vaccine is introduced it is first studied in a randomised controlled trial where some are given the drug and others are given an inert substance to check the effects and adverse effects among those given the Read More... -
The Indian Journal of Pediatrics, 85(7), 510-516 http://rdcu.be/EpEZ
Puliyel J, Naik P, Puliyel A, Agarwal K, Lal V, Kansal N, Nandan D, Tripathi V, Tyagi P, Singh SK, Srivastava R, Sharma U, Sreenivas V.
Evaluation of the Protection Provided by Hepatitis B Vaccination in India
Abstract
In India Hepatitis B vaccination is recommended at 6 weeks except for hospital-deliveries. We examined protection afforded by the birth dose.
Method A case-control study was done. HBsAg and HBcAb were tested in 2671 children 1 to 5 years and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis children who got infected (HBsAg and/o Read More... -
http://www.delhipost.live/ambitious-health-care-benefits-winning-votes-protecting-public-health/
Jacob Puliyel
Ambitious health care benefits: Winning votes while protecting public health
By Dr. Jacob Puliyel - on February 7, 2018 31 0
The recently announced enhanced benefits under the NHPS without allocating any money for it is an excellent move in ensuring that private sector is not preferred over public sector.
Data from the 70th round of theNational Sample Survey on ‘Household Indebtedness’ shows that nearly one in three rural households and over one in f Read More... -
https://f1000research.com/articles/7-243/v2
Puliyel J, Naik P.
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Med J DY Patil Vidyapeeth 2018;11:99-105. http://www.mjdrdypv.org/downloadpdf.asp?issn=2589-8302;year=2018;volume=11;issue=2;spage=99;epage=105;aulast=Puliyel;type=2
Jacob Puliyel, Jaspreet Kaur, Ashish Puliyel, Visnubhatla Sreenivas
Deaths Reported after Pentavalent Vaccine Compared with Death Reported after Diphtheria-Tetanus-Pertussis vaccine - An Exploratory Analysis
Abstract
Introduction
Immunization is one of the most effective public health tools available to prevent death and disease. Serious adverse reactions following immunization (AEFI) are rare. However coinci-dental sudden-infant-death-syndrome (SIDS) deaths do occur temporally associated with vac-cination. In 2010 the Government of India (GoI) introduced Read More... -
The Sunday Guardian http://www.sundayguardianlive.com/news/13137-vaccine-killing-children-instead-protecting-them
Jacob Puliyel.
The Pentavalent vaccine (PV), which was introduced by India six years ago, doubled the deaths of children soon after vaccination, compared to the DPT (Diphtheria-Pertussis-Tetanus) vaccine, says a new study that calls for a “rigorous review of the deaths following vaccination with PVâ€.
The study was conducted by Professor V. Sreenivas, Professor of Biostatistics, All India Institute of Medical Sciences. Government of India data was used throughout the study. I Read More... -
Journal of Clinical and Diagnostic Research [serial online] 2018 April [cited: 2018 Apr 11 ]; 12:SD03-SD04. Available from http://jcdr.net/back_issues.asp?issn=0973-709x&year=2018&month=April&volume=12&issue=4&page=SD03-SD04&id=11370 DOI: 10.7860/JCDR/2018/32696.11370
Aashish Gupta, Rahi Raza, Ayush Manchanda, Jacob Puliyel
Autoimmune Haemolytic Anaemia: An Unusual Manifestation of Kawasaki Disease Aashish Gupta, Rahi Raza, Ayush Manchanda, Jacob Puliyel
1. Resident, Department of Paediatrics, St Stephens Hospital, Delhi, India. 2. Resident, Department of Paediatrics, St Stephens Hospital, Delhi, India. 3. Consultant, Department of Paediatrics, St Stephens Hospital, Delhi, India. 4. Head of Department, Department of Paediatrics, St Stephens Hospital, Delhi, India.
Correspondence Address :
Dr. Jacob Puliyel Read More... -
https://www.sundayguardianlive.com/opinion/parliament-must-provided-correct-study-pentavalent
Jacob Puliyel.
Home
Opinion
Parliament must be provided with correct study on Pentavalent
Parliament must be provided with correct study on Pentavalent
JACOB PULIYEL
Updated : April 14, 2018, 5:58 PM
jacob
The deaths of healthy children taken for routine immunisation are not acceptable.
On 18 March, The Sunday Guardian published a report suggesting that Pentavalent vaccine was killing children instead of protecting them. In response to a question on the subject, Union Minister for Health an Read More... -
Indian Pediatrics 2018;55:438-9
Sandeep Lal Puliyel JM.
Using CPAP for Bronchiolitis: Authors' Reply
Sandeep Narayan Lal* and Jacob M Puliyel
Department of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi, India.
Email: sandeep.nlal@gmail.com
The main point of criticism of our study [1] by all these readers is that we assessed only for benefits over the first hour of admission. This is a valid point. The reason for such protocol was the ethical issue. Theoretically, it was not logical to use CPAP (that increases Read More... -
https://www.sundayguardianlive.com/news/ethical-questions-surround-vaccine-reduce-fertility
Jacob Puliyel
The prestigious journal Nature Medicine, in its February issue reported that the Indian Council of Medical Research (ICMR) is to do a clinical trial of a tetanus toxoid vaccine (TT) laced with a pregnancy hormone, human chorionic gonadotropin (hCG). It is to be studied on 120 women in India.
This “vaccine†against pregnancy was developed by Dr G.P. Talwar in 1972. The idea is to produce antibodies to the pregnancy hormone, such that the women would not be able Read More... -
Vaccine. 2018 Jun 13. pii: S0264-410X(18)30772-2. doi: 10.1016/j.vaccine.2018.05.105. Available online 13 June 2018
Lalit Kumar, Jacob Puliyel
Letter to the Editor
New pentavalent rotavirus vaccine shows little efficacy against diarrhea
Lalit Kumar
drlalitnarwat@gmail.com
Jacob Puliyel
Department of Pediatrics, St Stephens Hospital, Delhi 110054, India
âŽCorresponding author.
Keywords: Rotarix; Bovine human-reassortant pentavalent vaccine; Serum Institute of India
Rotavirus vaccine is recommended as a means of reducing diarrheal morbidity and deaths in developing countries [1]. The original efficacy studi Read More... -
Jacob Puliyel
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Int J Environ res Public Health 2018;15:1755 doi:10.3390/ijerph15081755 http://www.mdpi.com/1660-4601/15/8/1755/pdf
Rachana Dhiman , Sandeep C. Prakash, V. Sreenivas , Jacob Puliyel
Correlation between Non-Polio Acute Flaccid Paralysis Rates with Pulse Polio Frequency in India
Rachana Dhiman 1, Sandeep C. Prakash 1, V. Sreenivas 2 and Jacob Puliyel 1,*
1 Department of Pediatrics, St Stephens Hospital, Delhi 110054, India; dhimanrachna48@gmail.com (R.D.); sandeepcpp25@gmail.com (S.C.P.)
2 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 10029, India; sreenivas_vishnu@yahoo.com
* Correspondence: puliyel@gmail.com; Tel.: +91-986-803-5091
R Read More... -
https://www.bmj.com/content/363/bmj.k4152/rapid-responses https://www.bmj.com/content/363/bmj.k4152/rr-5
Jacob Puliyel
Editor's Choice
A tale of two vaccines
BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4152 (Published 04 October 2018)
Cite this as: BMJ 2018;363:k4152
Article
Related content
Article metrics
Rapid responses
Response
Making Science Obsolete
Rajagopal's suggestion that it's "incumbent on journals to indicate on the web pages when an article has
been rendered obsolete by new data" is novel and revolutionary.
There is then no need for meta-analysis and complica Read More... -
Disabil Health J. 2018 Oct 16. pii: S1936-6574(18)30198-5. doi: 10.1016/j.dhjo.2018.10.003.
Rahul Mopari Bhawna Garg Jacob Puliyel Sara Varughese
Measuring Disability in an Urban Slum Community in India Using the Washington Group Questionnaire
Rahul Mopari1 rahulm.doc@gmail.com
Bhawna Garg2 CFA thestatisticalanalyst@gmail.com
Jacob Puliyel1 puliyel@gmail.com
Sara Varughese3 sara.varughese@cbm.org
1. St Stephens Hospital Delhi,
2. Independent Statistician. 135 Bhagirathi, Sector 9, Rohini, Delhi
3. CBM India Liaison Office, Bangalore.
Address for communication
Sara Varughese FRCS
Country Director
CBM India
#140, &aci Read More... -
Int. J. Environ. Res. Public Health 2019, 16, 63; doi:10.3390/ijerph16010063 https://www.mdpi.com/1660-4601/16/1/63
Rachana Dhiman, Sandeep C. Prakash, V. Sreenivas and Jacob Puliyel.
Reply to Comment on Dhiman, R. et al. Correlation of Non-Polio Acute Flaccid Paralysis Rate with Pulse Polio Frequency in India. Int. J. Environ. Res. Public Health 2018, 15, 1755
Rachana Dhiman 1, Sandeep C. Prakash 1, V. Sreenivas 2 and Jacob Puliyel 1,* 1 Department of Pediatrics, St Stephens Hospital, Delhi 110054, India; dhimanrachna48@gmail.com (R.D.); sandeepcpp25@gmail.com (S.C.P.) 2 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 10029, India; sreenivas_ Read More... -
https://www.youtube.com/watch?v=L_I8remugnQ
Jacob Puliyel
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https://www.bmj.com/content/365/bmj.l1932/rr-12 Rapid Response BMJ to https://www.bmj.com/content/365/bmj.l1932/rr-8
Jacob Puliyel
Doublespeak is not 'post truth': It is Orwellian
F. Scott Fitzgerald is quoted to have said “The test of a first-rate intelligence is the ability to hold two opposed ideas in mind at the same time and still retain the ability to function.†I got a glimpse of this while reading the response of Jonathan J Kennedy.
Kennedy has agreed with everything the earlier correspondents Allan Cunningham, Elizabeth Hart, John Stone, Noel Thomas and JK Anand hav Read More... -
https://www.youtube.com/watch?v=1o_6XVWsRig
Jacob Puliyel
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https://www.bmj.com/content/365/bmj.l2268/rr-0 Response to Modernising vaccine surveillance systems to improve detection of rare or poorly defined adverse events BMJ 2019; 365 doi: https://doi.org/10.1136/bmj.l2268
Jacob Puliyel
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https://www.bmj.com/content/365/bmj.l2268/rr-10
Jacob Puliyel
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In Universalising health care in India: From care to coverage. Editors Imrana Qadeer, K B Saxena, P M Arathi. Aakar Books 2019 Delhi ISBN 978-93-5002-588-8 Page 287 - 310
Puliyel J
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https://journals.plos.org/plosmedicine/article/comment?id=10.1371/annotation/cbee7325-3eec-46a3-b128-1c8bb6372987
Kartiki K, Puliyel
Response to
Redesigning care for older people to preserve physical and mental capacity: WHO guidelines on community-level interventions in integrated care
Jotheeswaran Amuthavalli Thiyagarajan , Islene Araujo de Carvalho , Juan Pablo Peña-Rosas, Shelly Chadha, Silvio Paolo Mariotti, Tarun Dua, Emiliano Albanese, Olivier Bruyère, Matteo Cesari, Alan Dangour, Amit Dias, Mariella Guerra, Jill Keeffe, [ ... ], John R. Beard [ view all ]
Published: October 18, 2 Read More... -
Sunday Guardian Online before print https://www.sundayguardianlive.com/news/unethical-clinical-trials-vaccines-pose-threat-human-lives
Jacob Puliyel
‘Unethical’ clinical trials of vaccines pose threat to human lives
Jacob Puliyel
Published : November 11, 2019, 10:54 am | Updated : November 11, 2019, 10:54 AM
Primum non nocere "first, do no harm" is a basic tenet of medical ethics. That is about to change in India. It is planned to introduce “Controlled Human Infection Method†(CHIM) studies here. Humans are to be deliberately infected with diseas Read More... -
https://www.worldsdg2030.org/images/White-paper-Book.pdf Also Research Gate DOI 10.13140/RG.2.2.15881.60007
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Viral Immunol. 2019 Dec 13. doi: 10.1089/vim.2019.0090. [Epub ahead of print] PMID: 31834852 doi.org/10.1089/vim.2019.0090
Ranjan V, Mishra A, Kesarwani A, Mohan KV, Lal SN, Puliyel J, Upadhyay P.
Mother-to-Child Transfer of Reactivated Varicella-ZosterVirus DNA and Varicella-Zoster IgG in PregnancyVivek Ranjan,1Alaknanda Mishra,2Ashwani Kesarwani,2K. Varsha Mohan,2Sandeep Narayan Lal,1Jacob Puliyel,1and Pramod Upadhyay2 1Department of Pediatrics, St. Stephens Hospital, New Delhi, India.2National Institute of Immunology, New Delhi, India.VIRAL IMMUNOLOGYVolume 00, Number 00, 2019ªMary Ann Liebert, Inc.Pp. 1–5DOI: 10.1089/vim.2019.009 AbstractStress-induced Read More... -
Puliyel J
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https://thewire.in/health/coronavirus-pandemic-covid-19-lockdown-mortality-public-health-hydroxochloroquine-icmr-panic
Jacob Puliyel
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https://d3nyygebl2bi65.cloudfront.net/autismone2020.mp4
Jacob Puliyel
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Sunday Guardian https://www.sundayguardianlive.com/news/greshams-law-covid-19-pandemic
Jacob Puliyel
Gresham’s Law and the Covid-19 pandemic
Jacob Puliyel
• Published June 29, 2020, 11:04 am
• |
• Updated
• June
Gresham’s law holds that bad money drives out good money. If there are two coins with the same face value, but of different intrinsic value (assume that one is made of a more precious metal) the coin with less intrinsic worth (bad coin) will be used for cu Read More... -
https://www.bmj.com/content/370/bmj.m2670/rr-1
Jacob Puliyel
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https://d3nyygebl2bi65.cloudfront.net/s-NVIC_PULIYEL_JACOB.mp4
Jacob Puliyel
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BMC Pediatrics volume 20, Article number: 515 (2020) https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-020-02418-w
Aashish Gupta, Jacob Puliyel, Bhawana Garg & Pramod Upadhyay
Background
To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children.
Methods
A prospective observational study in a tertiary level Pediatrics ICU in Delhi, India. Seventy eight paediatric patients from 1 month to 12 years were studied. Children with physical trauma, post-surgical patients and patients Read More... -
https://d3nyygebl2bi65.cloudfront.net/WritPetition-combined.pdf
Jacob Puliyel, Prashant Bushan
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Prashant Bhushan, Cheryl D Souza, Jacob Puliyel
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SC 289 of 2016
S Srinivasan Prashant Bhushan Neha Rati
SECTION: PIL
IN THE SUPREME COURT OF INDIA
(CIVIL ORIGINAL JURISDICTION) WRIT PETITION (CIVIL) NO. 289 OF 2016
IN THE MATTER OF:
S. SRINIVASAN …. PETITIONER
VERSUS
UNION OF INDIA & ORS RESPONDENTS
FILING INDEX
S.NO. PARTICULARS COPIES C.FEE
1. ADDITIONAL AFFIDAVIT ON BEHALF OF THE PETITIONER 1 20/-
2. ANNEXURE P1 TO P5 1 NIL
NEW DEHI: DATED: 20.07.2021
(PRASHANT BHUSHAN) COUNSEL FOR THE PETITIONERS 301, NEW LAWYERS CHAMBERS SU Read More... -
Supreme Court PIL WRIT PETITION (CIVIL) NO. 607 OF 2021 IA no. 110625/2021
Prashant Bhushan, Cheryl D Souza, Jacob Puliyel
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Caravan 20 September 2021 https://caravanmagazine.in/health/the-little-discussed-risks-of-dna-vaccines-against-covid19
Jacob M Puliyel
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Supreme Court PIL WRIT PETITION (CIVIL) NO. 607 OF 2021 IA no. 110625/2021
Prashant Bhushan, Cheryl D Souza, Jacob Puliyel
SECTION: PIL
IN THE SUPREME COURT OF INDIA (CIVIL ORIGINAL JURISDICTION)
WRIT PETITION (CIVIL) NO. 607 OF 2021
IN THE MATTER OF:
DR. JACOB PULIYEL ...PETITIONERS VERSUS
UNION OF INDIA & ANR. …RESPONDENTS
FILING INDEX
S.NO. PARTICULARS COPIES
1. ADDITIONAL AFFIDAVIT ON BEHALF OF THE PETITIONER 1
2. ANNEXURE A1 TO ANNEXURE A3 1
NEW DEHI: DATED: 26.11.2021
(PRASHANT BHUSHAN) COUNSEL FOR THE PETITIONER 301, NEW LAWYERS CHAMBER Read More... -
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Prashant Bhushan Cheryl DeSouza
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Prashant Bhushan Jacob Puliyel
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PIL WRIT PETITION (CIVIL) NO. 607 OF 2021
Prashant Bhushan Cheryl D'Souza Jacob Puliyel
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Prashant Bushan Cheryl D Souza
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P Bhushan Cheryl DSouza Puliyel
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https://www.livelaw.in/pdf_upload/vaccinemandate-416470.pdf
L. NAGESWARA RAO, J.; B. R. GAVAI.
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The Leaflet https://theleaflet.in/right-to-self-determine-what-may-be-injected-into-our-bodies-is-fundamental-says-petitioner-in-the-vaccination-case-in-the-supreme-court/
Sarah Thanawala, J Puliyel
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https://ijme.in/articles/the-vaccine-mandates-judgment-some-reflections/?galley=html
Jacob Puliyel
Comments:
Jacob Puliyel
Visiting Professor, International Institute of Health Management Research Delhi , India
31 July 2022
I thank Srinivasan for his well-researched article.
I however think he has over-interpreted what he calls ‘Proposition A’
He writes
“The binary classification of vaccinated and unvaccinated groups of individuals, with respect to risks from virus transmission in Proposition A is too simplistic considering there is a r Read More... -
https://journals.plos.org/plosone/article/comment?id=10.1371/annotation/7a00e4c1-a526-4802-86f6-05343967519f
Sheetal Surjeet, Deepali Bhardwaj, Jacob Puliyel.
Sir
We commend the authors for their effort to find out why Canadians are not downloading COVID contact tracing apps. However, their effort to interrogate a representative sample of the population was frustrated by public suspicion or apathy which may have been the reason for the low uptake of the software in the first place.
Although the authors write that the response rate was 36%, only 4503 of the 14887 completed the questionnaire and the real response rate was only 30.24%. This must hav Read More... https://live.childrenshealthdefense.org/shows/good-morning-chd/fI-umbyMn5
Mary Holland, Jacob Puliyel, Dipali Ojha
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https://www.ghspjournal.org/content/10/5/e2200085/tab-e-letters#socio-demographic-factors-may-need-addressing-to-improve-the-survival-of-neonates-
Nida Shaikh, Tanya Singh, Sheetal Surjeet, Deepali Bhardwaj and Jacob Puliyel
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Page 20 to 31 State of Finance In India 2021-22. Focus on the Global South, Centre for Financial Accountability, Economic Research Foundation. Yoda Press New Delhi 49
Jacob Puliyel
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Jacob M Health Insurance: Drawing inspiration from chit funds to pool health risks efficiently. Indian Journal of Medical Ethics, [S.l.], v. VIII, n. 3, p. 255, jan. 2023. ISSN 0975-5691. Avaialble at: <https://ijme.in/articles/health-insurance-drawing-inspiration-from-chit-funds-to-pool-health-risks-efficiently/>.
Jacob Puliyel
Health Insurance: Drawing inspiration from chit
funds to pool health risks efficiently
Published online first on January 20, 2023. DOI: 10.20529/IJME.
2023.009
Keywords: out of pocket expenses, catastrophic health
expenditure, Rashtriya Swastha Bhima Yojana, ROSCA, adverse
selection, co payments
The provision of government-funded public health services
in India is grossly inadequate and 48.2% of “total health
expenditure” for India is paid “out of pocket” [1]. Wh Read More... -
https://gh.bmj.com/content/7/12/e009945.responses. Jackson C, Habibi R, Forman L, et al Between rules and resistance: moving public health emergency responses beyond fear, racism and greed BMJ Global Health 2022;7:e009945.
Jacob Puliyel Susanth George Thomas
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Preprint. https://www.preprints.org/manuscript/202303.0401/v1
Puliyel J
The Scientific Record: Examining some of the claims and counterclaims in the MMR saga
Comparison of the Lancet with the BMJ
The claim the Lancet paper reported 9 children with ‘regressive autism’ is incorrect.
Concerning these children, the term 'regressive autism' is used only in the BMJ. The Lancet
explicitly states that the diagnosis of ‘autism’ was made earlier elsewhere before admission.
Lancet: '…all had been assessed professionally else Read More... -
https://journals.lww.com/ijo/Fulltext/2023/71060/Prevention_of_avoidable_blindness_is_a_social.58.aspx Indian J Ophthalmol. 2023 Jun;71(6):2605. doi: 10.4103/IJO.IJO_3142_22. PMID: 37322695.
Singh M, Bhardwaj D, Singh T, Kaushik T, Puliyel J.
Prevention of avoidable blindness is a social imperative: Facile economic models do not help
Singh, Manoj; Bhardwaj, Deepali; Singh, Tanya; Kaushik, Tanuj; Puliyel, Jacob
Author Information
Indian Journal of Ophthalmology 71(6):p 2605, June 2023. | DOI: 10.4103/IJO.IJO_3142_22
Open
Dear Editor,
Economic models built by aggregating assumptions yield only a new set of assumptions, and these cannot be relied upon, except to the extent that they provide verifiable data points. The Read More...
